Setro 50 Tablet

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 19 Jan 2026 | 06:02 PM (IST)

Setro 50 Tablet is a medicine that is used to treat major depressive disorder (MDD) and obsessive-compulsive disorder (OCD). It works by increasing the levels of serotonin, a natural chemical in the brain that plays an important role in mood, emotions, and behavior.

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Setro 50 Tablet

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ZOsert 50 Tablet

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Sertraline (50mg)

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General Information

Contains

Sertraline (50mg)

Marketer

Kachhela Medex Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Setro 50 Tablet should be taken exactly as prescribed by your doctor. It can be taken with or without food, but it is best to take it at the same time each day to help you remember. Treatment for depression and OCD often takes several weeks before you start to feel the full benefit, so it is important to keep taking the medicine regularly and not stop suddenly, even if you feel better.

Stopping the medicine too quickly may cause withdrawal symptoms or make your condition return. For the best results, combine the treatment with healthy habits such as regular sleep, exercise, and support from family, friends, or counseling if recommended.

Some common side effects of Setro 50 Tablet include nausea, indigestion, loss of appetite, increased sweating, tremors, insomnia (difficulty in sleeping), and diarrhea. Sexual side effects like decreased sexual drive, delayed ejaculation, and erectile dysfunction may also be seen. Let your doctor know straight away if you develop any sudden worsening of mood or any thoughts about harming yourself.

Before taking this medicine, you should tell your doctor if you have epilepsy (seizure disorder or fits), diabetes, liver or kidney disease, heart problems, or glaucoma. These may affect your treatment. Pregnant or breastfeeding women should also consult their doctor before taking it. Some other medicines may affect the way it works, especially other antidepressants and medicines called MAO inhibitors. Inform your doctor about all the medicines you are taking to make sure you are safe.

Uses of Setro Tablet

Benefits of Setro Tablet

Treatment of Depression
Setro 50 Tablet helps lift the low mood, sadness, and loss of interest that come with depression. It helps improve energy, sleep, and overall mood, allowing people to get back to their routines, enjoy daily activities again, and feel more like themselves. Staying on treatment also lowers the chance of depression coming back, helping patients maintain stability and move forward with their lives.

Treatment of Obsessive-compulsive disorder
For people with OCD, Setro 50 Tablet reduces the unwanted thoughts and repetitive behaviors that interfere with daily life. It helps quiet the cycle of obsessions and compulsions, making it easier to focus, relax, and participate in normal activities at home, school, or work. With continued use, it not only improves day-to-day functioning but also helps prevent symptoms from returning, giving patients better long-term control.

Side effects of Setro Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Setro

Delayed ejaculation
Erectile dysfunction
Indigestion
Insomnia (difficulty in sleeping)
Low sexual desire
Nausea
Tremors
Diarrhea
Increased sweating
Loss of appetite
Sleepiness
Taste change

How to use Setro Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Setro 50 Tablet may be taken with or without food.

How Setro Tablet works

Setro 50 Tablet is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It works by increasing the levels of serotonin, a chemical messenger in the brain. This improves mood and physical symptoms of depression and also relieves symptoms of obsessive-compulsive disorder.

All substitutes for Setro 50 Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Do not drive or do anything requiring concentration until you know how Setro 50 Tablet affects you.
Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
Inform your doctor if you experience decreased sex drive or difficulty having an orgasm.
Do not stop taking the medication suddenly without talking to your doctor.

Safety advice

Alcohol

CAUTION

Alcohol should be used with caution while taking Setro 50 Tablet.

Pregnancy

CONSULT YOUR DOCTOR

Setro 50 Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CAUTION

Setro 50 Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.

Driving

UNSAFE

Setro 50 Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CONSULT YOUR DOCTOR

There is limited data available on the use of Setro 50 Tablet in patients with kidney disease. Please consult your doctor.

Liver

UNSAFE

Setro 50 Tablet is unsafe to use in patients with liver disease and should be avoided.

Interaction with drugs

Taking Setro with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Moclobemide (Oral Route)

Do not consume Moclobemide with Sertraline. If Moclobemide is essential, ensure a gap of at least 1 week after discontinuing Sertraline. Please consult your doctor.

Life-threatening

Tapentadol (Nasal Route)

Avoid concurrent use unless your doctor considers it safe.

Life-threatening

Zolmitriptan (Nasal Route)

If concurrent use is essential, watch out for symptoms of serotonin syndrome such as tremors, fever, diarrhea or agitation and consult your doctor if you experience them. Your doctor may monitor and adjust the doses as per the observations.

Life-threatening

Tranylcypromine (Oral Route)

Do not consume Tranylcypromine with Sertraline. If Tranylcypromine is essential, ensure a gap of at least 1 week after discontinuing Sertraline. Please consult your doctor.

Life-threatening

Selegiline (Oral Route)

Do not consume Selegiline with Sertraline. If Selegiline is essential, ensure a gap of at least 2 weeks after discontinuing Sertraline. Please consult your doctor.

Frequently asked questions

How long does it take for Setro 50 Tablet to work?

You may start noticing an improvement in symptoms within 7 days of taking Setro 50 Tablet. However, it may take longer to show a full response and will vary from person to person.

How long do I need to take Setro 50 Tablet?

You should continue taking Setro 50 Tablet as long as your doctor recommends taking it, which may be for several months. Doctors usually recommend the medicine for 6 months to a year after you no longer feel depressed. It is important to know that stopping the medication before the suggested time may cause depression to come back.

When is the best time to take Setro 50 Tablet?

Setro 50 Tablet is usually taken once a day and can be taken at any time of the day. It can be taken with or without food. Take it as per your convenience, but preferably at the same time each day. Some people who have sleep difficulty after taking Setro 50 Tablet should take it in the morning. Whereas some take it at night to limit the side effects of nausea and vomiting.

Does Setro 50 Tablet cause sleepiness?

Yes, Setro 50 Tablet may commonly cause sleepiness. In case you feel dizzy, sleepy, or tired after taking Setro 50 Tablet, you should avoid driving or using heavy machinery. This generally happens within the first few days and weeks after starting Setro 50 Tablet, which may disappear after 2-3 months of use of Setro 50 Tablet.

What does Setro 50 Tablet do for anxiety?

Setro 50 Tablet belongs to the selective serotonin reuptake inhibitor (SSRI) class of medicines. It increases the levels of serotonin, which is an important chemical and a neurotransmitter. This increase in serotonin levels can help to improve and regulate your mood, resulting in an improvement in the symptoms of anxiety.

Can I stop taking Setro 50 Tablet if I am better now?

No, you should not stop taking Setro 50 Tablet without consulting your doctor. This is because the sudden discontinuation of Setro 50 Tablet may cause withdrawal symptoms. Hence, it is important to gradually reduce the dose with time (over several weeks or months).

What are the withdrawal symptoms of Setro 50 Tablet?

The withdrawal symptoms of Setro 50 Tablet include dizziness, nausea, numbness or tingling in the hands or feet, trouble sleeping, feeling agitated or anxious, headaches, and shaking. However, these symptoms are generally mild to moderate and disappear after 1-2 weeks of discontinuing Setro 50 Tablet.

What are the symptoms of an overdose of Setro 50 Tablet?

The symptoms of overdose of Setro 50 Tablet include nausea, dizziness, fever, vomiting, confusion, shakiness, and a rapid heartbeat. Whereas, serious side effects include fainting, delirium, heart problems, and changes in blood pressure. If you experience such symptoms, immediately contact your doctor or seek emergency medical services in a nearby hospital.

Fact Box

Chemical Class

Tametralines

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Selective Seretonin Reuptake Inhibitors (SSRIs)

References

Stahl SM, editor. Sertraline. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 625-30.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1253-58.
Central Drugs Standard Control Organisation (CDSCO). [Accessed 22 Mar. 2019] (online) Available from:
Singh HK, Saadabadi A. Sertraline. [Updated 2023 Feb 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023. [Accessed 06 Aug. 2023] (online) Available from:
Kornstein SG, Pearlstein TB, Fayyad R, Farfel GM, Gillespie JA. Low-dose sertraline in the treatment of moderate-to-severe premenstrual syndrome: efficacy of 3 dosing strategies. J Clin Psychiatry. 2006 Oct;67(10):1624-32. [Accessed 06 Aug. 2023] (online) Available from:
Sertraline [Package Insert]. Gangtok, Sikkim: Torrent Pharmaceuticals Ltd.; 2022. [Accessed 06 Aug. 2023] (online) Available from:
Sertraline Hydrochloride [Prescribing Information]. Morgantown, WV: Viatris Specialty LLC; 2023. [Accessed 06 Aug. 2023] (online) Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Kachhela Medex Pvt Ltd
Address: Shop No. 335, 3rd Floor, Sandesh Dawa Bazar Near Haj House, Ganjipeth, Nagpur 440018

Vendor Details

Country of origin: India

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Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Setro 50 Tablet

Save more with additional offers

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Setro Tablet

Benefits of Setro Tablet

Side effects of Setro Tablet

How to use Setro Tablet

How Setro Tablet works

All substitutes for Setro 50 Tablet

Sertanil 50 Tablet

Daxid 50mg Tablet

SErta 50 Tablet

Serlift 50 Tablet

ZOsert 50 Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Moclobemide (Oral Route)

Tapentadol (Nasal Route)

Zolmitriptan (Nasal Route)

Tranylcypromine (Oral Route)

Selegiline (Oral Route)

Frequently asked questions

How long does it take for Setro 50 Tablet to work?

How long do I need to take Setro 50 Tablet?

When is the best time to take Setro 50 Tablet?

Does Setro 50 Tablet cause sleepiness?

What does Setro 50 Tablet do for anxiety?

Can I stop taking Setro 50 Tablet if I am better now?

What are the withdrawal symptoms of Setro 50 Tablet?

What are the symptoms of an overdose of Setro 50 Tablet?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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