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    Information about Sertraline

    Sertraline uses

    How sertraline works

    Sertraline is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It works by increasing the levels of serotonin, a chemical messenger in the brain. This improves mood and physical symptoms in depression and relieves symptoms of panic and obsessive disorders.

    Common side effects of sertraline

    Low sexual desire, Delayed ejaculation, Insomnia (difficulty in sleeping), Orthostatic hypotension (sudden lowering of blood pressure on standing), Nausea, Weight gain, Diarrhea, Erectile dysfunction, Stomach upset
    Content Details
    Written By
    Dr. Swati Mishra
    Reviewed By
    Dr. Lalit Kanodia
    MD (Pharmacology), MBBS
    Last updated on:
    05 Mar 2019 | 11:16 AM (IST)
    Want to know more?
    Read Our Editorial Policy

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    Expert advice for Sertraline

    • Sertraline effectively treats a variety of mental health conditions such as depression, anxiety, and panic disorders.
    • It is one of the more effective and better tolerated antidepressant medication.
    • It causes less sleepiness than other antidepressants.
    • It has been proven safe for depressed patients with recent myocardial infarction or angina.
    • Do not drive or do anything requiring concentration until you know how Sertraline affects you.
    • Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
    • The addiction/dependence potential of Sertraline is very less.
    • Inform your doctor if you experience decreased sex drive or difficulty having an orgasm.
    • Do not stop taking the medication suddenly without talking to your doctor.

    Frequently asked questions for Sertraline


    Q. Is Sertraline addictive?

    Sertraline is not addictive. However, sudden discontinuation or decrease in dose of Sertraline may cause effects like dizziness, numbness, sleep disturbances, agitation or anxiety, headaches, nausea, vomiting and shaking. Patients should follow the advice of the doctor regarding its use and discontinuation

    Q. Is Sertraline a mono amine oxidase inhibitor/steroid?

    No, Sertraline belongs to a class of medications called selective serotonin reuptake inhibitors (SSRIs), which alter the levels of a chemical called serotonin in the brain and help improve depression

    Q. Is Sertraline safe?

    Sertraline is safe, if used at prescribed doses for the prescribed duration as advised by your doctor

    Q. Does Sertraline cause insomnia/hair loss/ weight gain or loss/acne/sick feeling?

    Insomnia, headache, weight gain or weight loss and sick feeling are side effects reported with the use of Sertraline. However acne has not been reported. Patients should consult doctors regarding the possible side effects

    Q. Can I take Sertraline for anxiety?

    Sertraline is used for the treatment of social anxiety disorder. But, consult your doctor regarding the use of Sertraline for your anxiety complaints

    Q. Is Sertraline a stimulant?

    No, Sertraline belongs to a class of medications called selective serotonin reuptake inhibitors (SSRI) antidepressants. It does not stimulate the brain, but improves depression by increasing the levels of a chemical called serotonin in the brain

    Q. Can I take sertraline with diazepam/ Adderall (amphetamine and dextroamphetamine)/ alcohol/ Tylenol (paracetamol)/ mirtazapine/ amoxicillin/ Nyquil (acetaminophen, dextromethorphan, doxylamine)/ Co codamol (paracetamol and codeine)/ ibuprofen?

    With tramadol there is an increased risk of hypertension, amitriptyline may possibly change the blood levels of fluoxetine, and alcohol may alter the effect of fluoxetine. No clinically observed drug interaction has been reported with diazepam, Co codamol, Nyquil, ibuprofen and mirtazapine. Please consult your doctor when using concomitantly

    Q. How long can I take Sertraline/ Can I take Sertraline forever?

    It is advisable to take this drug only till prescribed by the doctor

    Q. Does Sertraline expire?

    Yes, like all drugs, Sertraline has an expiry date. Please refer to the package insert or the information on the tablet strip to find out when your medicine expires.

    Content on this page was last updated on 05 March, 2019, by Dr. Varun Gupta (MD Pharmacology)