Senpezil 5 Tablet


Overview

Introduction

Senpezil 5 Tablet is used to treat mild to moderate dementia in Alzheimer’s disease, a progressive illness which gradually affects memory and thinking. It does not cure this illnesses but may help improve memory, awareness and other symptoms.

Your doctor will explain how to take Senpezil 5 Tablet and give you the one most suitable for you. Follow the instructions carefully to get the most benefit. The dose may change from time to time to suit your individual needs. You may take it with food, preferably at night before going to bed. It can take up to few weeks for symptoms to improve so keep taking your medicine regularly. You should not stop taking this medicine without consulting your doctor.

Some common side effects of this medicine include diarrhea, nausea, and vomiting. Drink plenty of fluids to keep yourself hydrated. Some people may experience insomnia (sleeplessness), dizziness and hallucinations. You may have side effects more often when you start your treatment or when your dose is increased. Usually, the side effects will slowly go away as your body gets used to the Senpezil 5 Tablet. If they are severe or will not go away, you should  contact your doctor.

Before using Senpezil 5 Tablet, you should tell your doctor if you have ever had heart problems, stomach ulcer, epilepsy or asthma. It may also affect, or be affected by, some other drugs you are using so let your doctor know what these are to be safe. During pregnancy this medicine should only be taken if it is advised.

Uses of Senpezil Tablet

Side effects of Senpezil Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Senpezil

  • Nausea
  • Vomiting
  • Diarrhea

How to cope with side effects?

The occurrence of side effects varies from person to person. The following are a few ways of dealing with some of the common side effects. However, consult your doctor if these persist.

  • Coping with Nausea
    You can help yourself by eating small, frequent meals rather than large ones and drinking plenty of fluids. Eat slowly. Avoid fatty, fried, spicy and very sweet foods. Eat cold or slightly warm food if the smell of cooked or cooking food makes you feel sick. Get plenty of fresh air. You could also try chewing ginger or drinking ginger tea. Eat bananas to replace potassium in your blood which can drop if you are sick (vomit). Use oral rehydration salts to replace vitamins and minerals lost through being sick. There are some medicines that can help you stop from feeling sick. Speak to your doctor if your condition does not improve.
  • Coping with Vomiting
    You can help yourself by eating small, frequent meals rather than large ones and drinking plenty of fluids. Eat slowly. Avoid fatty, fried, spicy and very sweet foods. Eat cold or slightly warm food if the smell of cooked or cooking food makes you feel sick. Get plenty of fresh air. You could also try chewing ginger or drinking ginger tea. Eat bananas to replace potassium in your blood which can drop if you are sick (vomit). Use oral rehydration salts to replace vitamins and minerals lost through being sick. There are some medicines that can help you stop feeling sick. Speak to your doctor if your condition does not improve.
  • Coping with Diarrhea
    Keep up your intake of fluids and electrolytes (sugars and salts) to avoid getting dehydrated. Eat less fiber (avoid raw fruits, fruit juice and vegetables). Talk to your doctor about possible medication to manage diarrhea. Ask about reducing the dosage of your drug or other suitable treatments.

How to use Senpezil Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Senpezil 5 Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Senpezil Tablet works

Memory loss in Alzheimer’s disease occurs due to disturbances of signal transmission in the brain. Senpezil 5 Tablet is a cholinesterase inhibitor. It works by increasing the levels of a chemical messenger (acetylcholine) involved in transmmission of nerve signals. This improves memory and thinking.

Safety Advice

Alcohol
UNSAFE
It is unsafe to consume alcohol with Senpezil 5 Tablet.
Pregnancy
CONSULT YOUR DOCTOR
Senpezil 5 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breastfeeding
CONSULT YOUR DOCTOR
Senpezil 5 Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Senpezil 5 Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
SAFE IF PRESCRIBED
Senpezil 5 Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Senpezil 5 Tablet may not be needed in these patients. Please consult your doctor.
Liver
CAUTION
Senpezil 5 Tablet should be used with caution in patients with liver disease. Dose adjustment of Senpezil 5 Tablet may be needed. Please consult your doctor.

What if you forget to take Senpezil Tablet?

If you miss a dose of Senpezil 5 Tablet, skip it and continue with your normal schedule. Do not double the dose.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Senpezil 5 Tablet
₹10.7/Tablet
₹11.33/Tablet
6% costlier
Aricep 5 Tablet
Eisai Pharmaceuticals India Pvt Ltd
₹11.4/Tablet
7% costlier
Alzil 5 Tablet
Intas Pharmaceuticals Ltd
₹11.49/Tablet
7% costlier
Donep 5 Tablet
Alkem Laboratories Ltd
₹12.32/Tablet
15% costlier
Pezil 5mg Tablet
Synokem Pharmaceuticals Ltd
₹18.59/Tablet
74% costlier

Quick Tips

  • You have been prescribed Senpezil 5 Tablet to slow down the progression of Alzheimer's disease.
  • It does not cure Alzheimer's disease but may help improve brain function and ability to do daily activities.
  • Take it with or without food, preferably at night before going to bed.
  • It may cause diarrhea, nausea, and vomiting. Drink plenty of fluids to keep yourself hydrated while taking Senpezil 5 Tablet.
  • Monitor your body weight regularly as both Senpezil 5 Tablet and  Alzheimer's disease can cause weight loss.
  • Do not drive or do anything that requires mental focus until you know how Senpezil 5 Tablet affects you.
  • Be cautious while taking this medicine if you suffer from peptic ulcer as it may cause vomiting, stomach bleeding, stomach pain, or discomfort.
  • Inform your doctor if you develop muscle tremors, especially if you have Parkinson’s disease.
  • Inform your doctor if you experience seizures or convulsions while taking this medicine.

Fact Box

Chemical Class
Carbamate Derivative
Habit Forming
No

Interaction with Drugs

Taking Senpezil with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Atroped, Atronir, Mydrat-J
LIFE-THREATENING
Brand(s): Bigspas
LIFE-THREATENING
Brand(s): Cholipan, Hyozen, Buscotag
LIFE-THREATENING
Brand(s): Menoctyl
LIFE-THREATENING

Patient Concerns

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Why the failure of Alzheimer's therapy now a days???
Dr. Vikas Sharma
Neurology
as the disese mechanisms are still not defined in absolute terms; still PATIENT is needed and is ongoing
Sir, My father ( an advocate) has developed symptoms of Alzheimer recently and sometimes he takes medicines on his own. He gets weak and unable to walk after taking tablets. Is there any test which can tell which medicines that he took? He takes Ayurved, Allopath, Homeopathy all and does not listen to me. Kindly help
Dr. Ila Jain Khandelwal
Pathology
Dear Sir Thank you for consulting with me. Alzheimer's disease is a difficult disease to handle since patient develops dementia or forgetfulness. There are no blood tests which can tell you which medicines he took. Please consult a neurologist/ Psychiatrist
arrow
Do you have any questions related to Senpezil 5 Tablet ?

User Feedback


FAQs

Q. Why is Senpezil taken at night?

Senpezil is recommended to be taken before going to bed to reduce gastrointestinal side effects or nausea, which is commonly seen in some patients in the first few weeks of treatment.

Q. Do the gastrointestinal side effects due to Senpezil persist for a long time?

Gastrointestinal side effects may appear during the first few weeks of treatment with Senpezil. This can be minimized by taking Senpezil at bedtime and with food. Generally, these side effects are mild and disappear within a few weeks with continued treatment.

Q. How long does it take for Senpezil to start working?

Within the first month of treatment with Senpezil, you may experience improvement in thinking and remembering (cognitive effect). However, it may take about 12 weeks to see the full benefits.

Q. When should Senpezil be stopped?

Do not stop Senpezil without consulting your doctor. This medicine only helps to control your condition but does not cure it. Therefore, it may take several weeks to show benefits, so do not be discouraged if you do not see an improvement straight away. But, in case your condition starts worsening and you feel that it is no longer helping you, then you should consult a doctor before stopping it.

Q. For how long does Senpezil stay in your system?

Senpezil gets removed from the body very slowly. It takes about two weeks or more for Senpezil to be completely removed from the system.

Q. Does Senpezil cause depression?

No, Senpezil does not cause depression. If you are experiencing symptoms, then it could be due to existing Alzheimer’s disease.

Q. What if I take more than the prescribed dose of Senpezil?

Taking more than the recommended dose of Senpezil may cause vomiting, increased sweating or saliva production, slow heartbeat, dizziness, difficulty in breathing, seizures or fits, weakness, and inability to control your bowel motions or passing of urine (incontinence). You should seek immediate help from a doctor or emergency service of a nearby hospital.

Q. I have been taking indomethacin for arthritis. Can I take Senpezil?

Senpezil does not interfere with the working of indomethacin, but indomethacin individually increases the risk of stomach bleeding when taken for a long time. Therefore, if you experience any symptoms of stomach bleeding, consult your doctor immediately.

Q. Does Senpezil cause hallucinations?

Hallucinations are a common side effect of Senpezil, though not everyone is affected. Other common psychiatric side effects include agitation, aggressive behavior, nightmares, and abnormal dreams.

Q. Who should not take Senpezil?

Senpezil should not be taken by patients who have hypersensitivity to Senpezil hydrochloride, piperidine derivatives, or to any active ingredients used in the medicine. Also, it should not be used during pregnancy unless clearly necessary.

Q. Can it cause insomnia?

Yes, insomnia (sleeplessness) is a common side effect of Senpezil. Dizziness and fainting can also be seen as common side effects. Though these side effects are common, they do not occur in everyone.

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1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Stahl SM, editor. Donepezil. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 199-202.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 426-27.
  3. Donepezil hydrochloride. Woodcliff Lake, New Jersey: Eisai Inc.; 1996 [revised Feb. 2012]. [Accessed 25 Jan. 2019] (online) Available from:External Link
  4. Donepezil. Hatfield, Hertfordshire: Eisai Ltd.; 1997 [revised 11 May 2018]. [Accessed 25 Jan. 2019] (online) Available from:External Link
  5. Donepezil hydrochloride. South Ruislip, UK: Aurobindo Pharma - Milpharm Ltd.; 2013 [revised 23 Nov. 2017] [Accessed 19 Jun. 2019] (online) Available from:External Link
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed 22 Mar. 2019] (online) Available from:External Link

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