Information about Dosulepin

Dosulepin Uses

Dosulepin is used in the treatment of anxiety disorder and depression. It is used in patients intolerant of or unresponsive to alternative other treatment options for depression.

How Dosulepin works

Dosulepin is a tricyclic antidepressant. It increases the levels of chemical messengers in the brain that help in regulating the mood and treat depression.

Common side effects of Dosulepin

Dryness in mouth, Difficulty in urination, Constipation, Dizziness, Sedation, Loss of accommodation
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MD (Pharmacology), MBBS
Last updated
29 Sep 2021 | 07:13 AM (UTC)

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Expert advice for Dosulepin

  • It may take 4 to 6 weeks for Dosulepin to start working. Keep taking it as prescribed.
  • It may cause sleepiness. Take it at bedtime and do not drive or do anything requiring concentration until you know how it affects you.
  • Avoid consuming alcohol when taking Dosulepin as it may cause excessive sleepiness.
  • Monitor your weight during the treatment as this medicine can cause weight gain and increased appetite.
  • Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.

Frequently asked questions for Dosulepin


Q. What is Dosulepin used for?

Dosulepin is a medicine used to treat anxiety disorder and depression that is unresponsive to other alternative medicines. It is also used to relieve nerve pain and fibromyalgia. Dosulepin should be taken only if prescribed by a doctor, exactly as directed.

Q. Is Dosulepin a muscle relaxant?

No. Dosulepin is not a muscle relaxant. It is a tricyclic antidepressant (TCA) used in the treatment of depression, nerve pain, and anxiety disorder.

Q. What is the difference between Dosulepin and amitriptyline?

Dosulepin is chemically related to Amitriptyline and both are tricyclic antidepressant (TCA) medicine. There is overlap in pharmacological property of this medicine.

Q. Is Dosulepin the same as doxepin?

Dosulepin and doxepin are different medicines but belong to the similar chemical class. Doxepin, at low doses, can improve sleep in patients with insomnia. It is also available in the topical form for use in various neuro-dermatitis syndrome, especially itching.

Q. How to stop Dosulepin?

If your doctor asks you to stop Dosulepin, you should reduce the dose slowly over 4 weeks. You should not discontinue it abruptly. Sudden discontinuation may cause aggression, anxiety, blurred vision, concentration impairment, constipation and crying spell.

Q. Is Dosulepin fatal?

Yes. Dosulepin can be fatal (can cause death) in overdose. This is due to a life-threatening or dangerous side effect in overdose like hyperthermia, seizure, arrhythmia, tachycardia, orthostatic hypotension or sudden death. That's why it is generally not considered a first-line option for depression because of side effect profile.

Q. Can I take Dosulepin with diazepam?

It is better to avoid this combination. Diazepam is a sedative drug and Dosulepin may cause sedation as a side effect too. Taking both of them together can increase the drowsiness or sleepiness. Inform your doctor if you are taking diazepam.

Q. Can Dosulepin be used in the treatment of trigeminal neuralgia?

No. Dosulepin is not approved for the treatment of trigeminal neuralgia. Trigeminal neuralgia is a chronic pain condition that affects the trigeminal or 5th cranial nerve, one of the most widely distributed nerves in the head.

Q. Can Dosulepin be used in the treatment of burning mouth syndrome?

No. Dosulepin is not approved for the treatment of burning mouth syndrome. Burning mouth syndrome is a painful condition of mouth that is burning, scalding, tingling or feeling of numbness that may occur every day for months or longer.

Q. Can I take Dosulepin for depression?

Yes. Dosulepin is indicated for the treatment of depression. It has a potential advantage in the patient with depression if associated with insomnia and anxiety. It is generally not considered a first-line option for depression because of side effect profile but very useful for severe or treatment-resistant depression.

Q. Can Dosulepin used to treat IBS (Irritable Bowel Syndrome)?

No. Dosulepin is not approved for the treatment of Irritable Bowel Syndrome (IBS). Irritable Bowel Syndrome is a functional gastrointestinal disorder characterised by chronic or recurrent abdominal pain or discomfort associated with altered bowel habits.

Q. Can Dosulepin be used to treat insomnia with depression?

Yes. Dosulepin may be used for the treatment of insomnia (too much arousal both at night and during the day) associated with depression. Because it can cause drowsiness or sedation as side effects, it is effective in treating insomnia associated with depression.

Q. Can I use Dosulepin for fibromyalgia?

Yes. Dosulepin is not approved for the treatment of fibromyalgia. Fibromyalgia is a pain syndrome with tenderness but no structural pathology in muscles, ligamanets or joints.

Q. Can I use Dosulepin for nerve pain?

Yes. Dosulepin is indicated for the treatment of nerve pain/neuropathic pain. Chronic pain/Neuropathic pain is described as pain that arises from damage to, or dysfunction of, any part of peripheral or central nervous system. It is associated with the disease which can affect nerves like diabetes mellitus or herpes infections.


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