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Dosulepin is used in the treatment of depression

How it works

Dosulepin increases the levels of chemical messengers in the brain that help in regulating the mood and treat depression.

Common side effects

Sleepiness, Blurred vision, Increased heart rate, Orthostatic hypotension (sudden lowering of blood pressure on standing), Weight gain, Difficulty in urination, Constipation, Dry mouth

Available Medicine

  • ₹61 to ₹127
    Abbott India Ltd
    3 variant(s)
  • ₹33 to ₹50
    D D Pharmaceuticals
    2 variant(s)

Expert advice

Do not take the medicine, If you are allergic to dosulepin, take it as single dose preferably at night.
Consult your doctor before taking dosulepin:
  • If you are an elderly patient.
  • If you have problems of bed wetting at night.
  • If you have ever had a heart attack.
  • If you are pregnant or planning to become pregnant or breast-feeding a baby.
Do not drive or operate machines after taking dosulepin as it may cause dizziness or tiredness.

Frequently asked questions



What is dosulepin?
Dosulepin is and SNRI (serotonin-norepinephrine reuptake inhibitor) and its chemical structure class is tricyclic antidepressant


Is it an SSRI (selective serotonin reuptake inhibitor)/ tricyclic antidepressant/ MAOI (monamine oxidase inhibitors)/muscle relaxant?
It is not an SSRI/MAOI/muscle relaxant


How does dosulepin work?
Dosulepin belongs to a class of medication call tricyclic anti-depressants. It acts on the central nervous system by blocking release of certain chemicals thus producing an anti-depressive effect

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Is dosulepin the same as doxepin?
Dosulepin has some structural similarity with doxepin, but it is not the same as doxepin


Is dosulepin safe or addictive?
Dosulepin is safe if used for an indication and a dose prescribed by your doctor. It may be addictive and hence should be taken only under the supervision of a doctor


Can I take Tramadol, Sertraline, Diazepam/Amitriptyline/Paracetamol/Zopiclone/ Gabapentin/Ibuprofen?
Dosulepin is known to interact with sertaline (SSRI anti-depressant), Diazepam (benzodiazepine-anti anxiety), amitriptyline (tricyclic antidepressant), zopiclone (cyclopyrrolone) /Gabapentin (Neurontin for seizure). It is not known to interact with Tramadol (pain-killer)/Paracetamol/Ibuprofen. Doctor's permission must be clearly sort for taking any other drug along with dosulepin


Can dosulepin cause weight gain/anxiety/sleep loss/headache/low or high blood pressure/decrease in sperm count?
Dosulepin is known to have side effects like anxiety, sleep loss/headache/low or high blood pressure. It is not clearly known to cause weight gain or decrease sperm count. It may cause an increase or decrease in sexual desire.

Content on this page was last updated on 07 April, 2017, by Dr. Varun Gupta (MD Pharmacology)