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Donepezil is used in the treatment of alzheimer's disease and dementia in parkinson's disease.
It should be used in patients with moderate to severe Alzheimer's disease.

How it works

Memory loss in Alzheimer’s disease is due to disturbance of message signals in the brain. Donepezil works by increasing the levels of acetylcholine, a chemical messenger involved in the transmission of nerve signals.

Common side effects

Nausea, Vomiting, Loss of appetite, Fatigue, Insomnia (difficulty in sleeping), Diarrhoea, Muscle cramp

Available Medicine

  • ₹119 to ₹350
    Eisai Pharmaceuticals India Pvt Ltd
    3 variant(s)
  • ₹102 to ₹185
    Intas Pharmaceuticals Ltd
    4 variant(s)
  • ₹149 to ₹230
    Sun Pharmaceutical Industries Ltd
    4 variant(s)
  • ₹100 to ₹140
    Cipla Ltd
    2 variant(s)
  • ₹138 to ₹172
    La Renon Healthcare Pvt Ltd
    2 variant(s)
  • ₹143 to ₹235
    Alkem Laboratories Ltd
    4 variant(s)
  • ₹76 to ₹133
    Shine Pharmaceuticals Ltd
    2 variant(s)
  • ₹66 to ₹91
    Altius Life Sciences
    2 variant(s)
  • ₹106
    Sun Pharmaceutical Industries Ltd
    1 variant(s)
  • ₹72
    Mission Research Laboratories Pvt Ltd
    1 variant(s)

Expert advice

  • Do not take donepezil hydrochloride, if you are allergic to donepezil hydrochloride or any of the other ingredients of this medicine. 
  • Avoid using donepezil hydrochloride, if you are breastfeeding.
  • Doctor’s advice should be considered in case of patients with following history of disease conditions: stomach or duodenal ulcers; seizures (fits) or convulsions; heart condition (irregular or very slow heart beat); asthma or other long term lung disease; liver problems or hepatitis; urine or mild kidney disease.
  • Do not use donepezil hydrochloride, if you are pregnant. 
  • Donepezil hydrochloride is not intended for use in children and adolescents younger than 18 years.
  • Donepezil hydrochloride should not be taken with alcohol because alcohol may change its effect.
  • Do not drive or operate machinery.

Frequently asked questions


Q. What is donepezil hydrochloride/ what is donepezil hydrochloride used for/ what does donepezil hydrochloride do?
Donepezil hydrochloride belongs to a group of medicines called acetylcholinesterase inhibitors and is used to treat the symptoms of dementia (which includes increasing memory loss, confusion and behavioral changes) in people diagnosed as having mild and moderately severe Alzheimer's disease
Q. Does donepezil Hcl work?
Donepezil hydrochloride does work, but its effectiveness can be different based on individual response.

Content on this page was last updated on 24 April, 2017, by Dr. Varun Gupta (MD Pharmacology)