Renasel 400mg Tablet

Sevelamer (400mg)

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Renasel 400mg Tablet is used to treat increased phosphate levels in the blood. It is used in patients who are on dialysis due to severe kidney disease. It inhibits the absorption of phosphate from the intestine and lowers the phosphate levels in the blood.

Written By Dr. Subita Alagh, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 31 Mar 2026 | 02:31 PM (IST)

₹191 MRP ₹209.069% off

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General Information

Contains

Sevelamer (400mg)

Marketer

Taj Pharma India Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Renasel 400mg Tablet should be taken with food. Take it in the dose and duration as advised by your doctor. Take it regularly and at a fixed time each day to get the maximum benefit of the medicine.

Renasel 400mg Tablet may cause side effects such as nausea, vomiting, abdominal pain, constipation, and diarrhea. You may also develop low levels of calcium, folic acid, and vitamins A, D, E, and K in your blood. Take necessary supplements as advised by your doctor.

Uses of Renasel Tablet

High phosphate levels in blood

Benefits of Renasel Tablet

High phosphate levels in blood
Renasel 400mg Tablet is used to manage high phosphate levels in the blood, especially in people with chronic kidney disease on dialysis. It helps control phosphate buildup, which supports healthy bones and prevents problems like bone pain, itching, and complications related to the heart and blood vessels.

Side effects of Renasel Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Renasel

Abdominal pain
Diarrhea
Flatulence
Nausea
Vomiting
Constipation

How to use Renasel Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Renasel 400mg Tablet should be taken with or after food.

How Renasel Tablet works

Renasel 400mg Tablet inhibits the absorption of phosphate from the intestine and lower the phosphate levels in the blood.

All substitutes for Renasel 400mg Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Renasel 400mg Tablet is used to control blood phosphate level in patients that are on dialysis treatment.
You must take it with food and stick to the diet prescribed by your doctor.
You may develop low levels of calcium, folic acid, and vitamins A,D,E, and K in your blood. Your doctor may prescribe supplements, if necessary.
Avoid taking any other medicine 1 hour before or 3 hours after taking Renasel 400mg Tablet.
Inform your doctor if you have nausea, vomiting, constipation, pain in the abdomen, or if you have undergone any major stomach surgery.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Renasel 400mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Renasel 400mg Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CONSULT YOUR DOCTOR

Renasel 400mg Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

SAFE

Renasel 400mg Tablet does not usually affect your ability to drive.

Kidney

CONSULT YOUR DOCTOR

There is limited data available on the use of Renasel 400mg Tablet in patients with kidney disease. Please consult your doctor.

Liver

SAFE IF PRESCRIBED

Renasel 400mg Tablet is probably safe to use in patients with liver disease. Limited data suggest dose adjustment may not be needed.

Interaction with drugs

Taking Renasel with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Ofloxacin (Oral Route)

To take Ofloxacin, ensure a gap of at least 1 hour before and 3 hours after taking Sevelamer. Sevelamer may reduce blood levels of Ofloxacin.

Moderate

Sparfloxacin (Oral Route)

To take Sparfloxacin, ensure a gap of at least 1 hour before and 3 hours after taking Sevelamer. Sevelamer may reduce blood levels of Sparfloxacin.

Moderate

Norfloxacin (Oral Route)

To take Norfloxacin, ensure a gap of at least 1 hour before and 3 hours after taking Sevelamer. Sevelamer may reduce blood levels of Norfloxacin.

Moderate

Levofloxacin (Oral Route)

To take Levofloxacin, ensure a gap of at least 1 hour before and 3 hours after taking Sevelamer. Sevelamer may reduce blood levels of Levofloxacin.

Moderate

Ciprofloxacin (Oral Route)

To take Ciprofloxacin, ensure a gap of at least 1 hour before and 6 hours after taking Sevelamer. Sevelamer may reduce blood levels of Ciprofloxacin.

Frequently asked questions

Is Renasel 400mg Tablet taken with food?

Yes, Renasel 400mg Tablet can be taken with food. It is recommended to take 1-2 tablets (based on individual needs) thrice daily. It is important to take it with meals because Renasel 400mg Tablet works by binding to phosphate from food. Take it exactly as advised by your doctor.

Can Renasel 400mg Tablet be crushed?

No, you should not crush, chew, or break Renasel 400mg Tablet into pieces. You should swallow it as a whole with water.

Why is it important for me to take Renasel 400mg Tablet?

It is important to take Renasel 400mg Tablet as patients undergoing dialysis cannot control the phosphate levels in their blood, especially after a meal. When the level of phosphate exceeds above the range in the blood, it may cause problems such as itchy skin, red eyes, high blood pressure, bone pain, and also increase the risk of fractures. These increased serum phosphate levels are reduced by Renasel 400mg Tablet, as it binds phosphate from food in the digestive tract.

Does Renasel 400mg Tablet cause constipation?

A common side effect of Renasel 400mg Tablet is constipation, though it does not occur in everyone. The other common side effects of the stomach and intestine include diarrhea, indigestion, flatulence, and pain in the abdomen. Immediately consult your doctor if these side effects become severe and disturb you.

Who should not take Renasel 400mg Tablet?

Patients who are allergic to Renasel 400mg Tablet and who have low levels of phosphate in blood should avoid taking Renasel 400mg Tablet. Additionally, patients having intestinal obstruction should also avoid using Renasel 400mg Tablet.

Can I take ciprofloxacin while I am taking Renasel 400mg Tablet?

Ciprofloxacin may interfere with the working of Renasel 400mg Tablet and therefore it should not be taken at the same time as Renasel 400mg Tablet. However, if taken together then a gap of at least 2 hours before or 6 hours after taking Renasel 400mg Tablet should be maintained.

How long do I need to take Renasel 400mg Tablet?

Continue taking Renasel 400mg Tablet as long as recommended by your doctor. Renasel 400mg Tablet lowers your dietary phosphate levels but does not cure your disease. Hence, you may have to take it lifelong, as stopping Renasel 400mg Tablet may increase your phosphate levels.

Do I need to have any tests while taking Renasel 400mg Tablet?

Yes, serum phosphate levels should be monitored regularly while you are taking Renasel 400mg Tablet. Also, the use of Renasel 400mg Tablet may decrease the levels of vitamin D, A, E, K, and folic acid and hence the levels need to be monitored during the treatment.

Fact Box

Chemical Class

Epoxides

Habit Forming

Therapeutic Class

BLOOD RELATED

Action Class

Phosphorus Binders

Related lab tests

Calcium

Phosphorus, Serum

Phosphorus, Urine

References

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 1259.
Sevelamer hydrochloride. Guildford, Surrey: SANOFI; 2000 [revised 20 Dec. 2018]. [Accessed 30 Jan. 2019] (online) Available from:
Sevelamer. Cambridge, USA: Genzyme Corporation; 1998. [Accessed 6 Apr. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 6 Apr. 2019] (online) Available from:
Sevelamer Carbonate [Product Information]. Ahmedabad, Gujarat: La Renon. [Accessed 06 Aug. 2023]. (online) Available from:
National Center for Biotechnology Information. PubChem Compound Summary for , Sevelamer. [Accessed 06 Aug. 2023]. (online) Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Taj Pharma India Ltd
Address: first floor, 15-6-108 afzal gunj, hyderabad, telangana 500012

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Renasel 400mg Tablet

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Renasel Tablet

Benefits of Renasel Tablet

Side effects of Renasel Tablet

How to use Renasel Tablet

How Renasel Tablet works

All substitutes for Renasel 400mg Tablet

Phosgood 400mg Tablet

Revlamer 400 Tablet

Sevcar 400 Tablet

Acutrol C 400 Tablet

Acutrol 400 Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Ofloxacin (Oral Route)

Sparfloxacin (Oral Route)

Norfloxacin (Oral Route)

Levofloxacin (Oral Route)

Ciprofloxacin (Oral Route)

Frequently asked questions

Is Renasel 400mg Tablet taken with food?

Can Renasel 400mg Tablet be crushed?

Why is it important for me to take Renasel 400mg Tablet?

Does Renasel 400mg Tablet cause constipation?

Who should not take Renasel 400mg Tablet?

Can I take ciprofloxacin while I am taking Renasel 400mg Tablet?

How long do I need to take Renasel 400mg Tablet?

Do I need to have any tests while taking Renasel 400mg Tablet?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Calcium

Phosphorus, Serum

Phosphorus, Urine

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests