Author Details
Written By
BDS
Reviewed By
MD (Pharmacology), MBBS
Last updated
21 Dec 2023 | 03:11 PM (IST)

We provide you with authentic, trustworthy and relevant information

Want to know more

Have issue with the content?

Report Problem

PYRA 500MG TABLET

Prescription Required
Marketer
SALT COMPOSITION
Storage
Store below 30°C

Product introduction

PYRA 500MG TABLET is an antibiotic that belongs to a class of medicines known as anti tuberculosis drugs. It is used in the treatment of tuberculosis, an infectious disease that mainly affects the lungs and in some cases other parts of the body.

PYRA 500MG TABLET is given in combination with at least one other tuberculosis medicine. It acts by killing the causative bacteria. It should be used in the dose and duration as advised by your doctor. This medicine may be taken with or without food, preferably at a fixed time every day to avoid a missed dose. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early can result in treatment failure and increase the side effects too. Please let your doctor know about any changes in your weight as the dose of this medicine depends on the overall body weight of a person. Any changes in weight might need dose modification.

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose, as it may increase the side effects.

Inform your doctor if you notice signs of jaundice i.e. yellowing of eyes or skin, dark urine, stomach pain or joint pain. You may also develop hepatitis (viral infection of the liver), increased liver enzymes and joint pain as side effects of this medicine. Please consult your doctor, as these side effects require medical attention and might need dose modification.

Your doctor may monitor your liver function while on treatment with this medicine. Avoid drinking alcohol as this may have additional adverse effects on the liver. Pregnant or breastfeeding women should consult their doctor before using this medicine.

Uses of Pyra Tablet

Benefits of Pyra Tablet

In Tuberculosis (TB)

PYRA 500MG TABLET is used to treat tuberculosis, an infectious disease that mainly affects the lungs but can affect other parts of the body as well. It stops the growth of infection causing bacteria and helps in treating the infection. Take it in the dose and duration advised by the doctor. Your symptoms may improve before the infection is completely cured. Do not stop taking it without consulting your doctor as doing so may cause the infection to return or worsen. Follow your doctor’s instructions carefully to get maximum benefit.

Side effects of Pyra Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Pyra

  • Jaundice
  • Hepatitis (viral infection of liver)
  • Increased liver enzymes
  • Joint pain

How to use Pyra Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. PYRA 500MG TABLET may be taken with or without food, but it is better to take it at a fixed time.

How Pyra Tablet works

PYRA 500MG TABLET is an antitubercular medicine. In the body, it gets converted to pyrazinoic acid. This pyrazinoic acid inhibits fatty acid synthase I (bacterial enzyme), which is essential for bacterial growth. Thus, it works as a bacteriocidal to prohibit their growth and treats tuberculosis.

Safety advice

Alcohol
CAUTION
Caution is advised when consuming alcohol with PYRA 500MG TABLET. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
PYRA 500MG TABLET may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
SAFE IF PRESCRIBED
PYRA 500MG TABLET is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Driving
CONSULT YOUR DOCTOR
It is not known whether PYRA 500MG TABLET alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Kidney
CAUTION
PYRA 500MG TABLET should be used with caution in patients with severe kidney disease. Dose adjustment of PYRA 500MG TABLET may be needed. Please consult your doctor.
Kidney function tests are advised before you start taking this medicine.
Liver
CAUTION
PYRA 500MG TABLET should be used with caution in patients with liver disease. Dose adjustment of PYRA 500MG TABLET may be needed. Please consult your doctor.
Regular monitoring of liver function tests is advised before and after the start of the treatment.

What if you forget to take Pyra Tablet?

If you miss a dose of PYRA 500MG TABLET, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine

Quick tips

  • PYRA 500MG TABLET along with other medications effectively treats tuberculosis.
  • Do not to forget a dose, as this increases the risk of the bacteria becoming resistant to the medicine, and also increases the risk of getting side effects.
  • Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
  • Avoid drinking alcohol while taking PYRA 500MG TABLET as this may increase the risk of side effects on the liver.
  • Use a reliable contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while you are taking PYRA 500MG TABLET as it may make hormonal contraceptives such as the pill less effective.

Fact Box

Chemical Class
Nicotinic acid derivatives
Habit Forming
No
Therapeutic Class
ANTI INFECTIVES
Action Class
Mycobacterial fatty acid synthase

Interaction with drugs

Taking Pyra with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Seloric, Aluric, Alopinol
Life-threatening

Patient concerns

arrow
My daughter is given tb medicine even though she is not infected taking these medicine will cause tb???
Dr. Rahul Yadav
Paediatrics
Hello, TB medicines are given only when there is indication of tuberculosis. They are for treating tuberculosis.
Though took vaccines in childhood, the test for TB came positive. Was advised to undergo treatment.physically absolute fit and healthy, is it advisable to take treatment?
Dr. Anshum Aneja Arora
Pulmonology
If sputum is positive for Tb , treatment is absolutely essential. Read more at www.arohealth.com/tuberculosis
arrow

User feedback


FAQs

Q. What is PYRA 500MG TABLET and what is it used for?

PYRA 500MG TABLET is an antibiotic. It is used in combination with other antibiotics in the treatment of tuberculosis

Q. Is PYRA 500MG TABLET bactericidal?

PYRA 500MG TABLET is both a bacteriostatic and a bactericidal antibiotic. It stops the growth of bacteria (bacteriostatic) in certain cases and kills (bactericidal) the tuberculosis causing bacteria in other cases

Q. How does PYRA 500MG TABLET work/treat tuberculosis?

PYRA 500MG TABLET kills or stops growth of bacteria that causes tuberculosis (Mycobacterium tuberculosis). The exact mechanism of action for PYRA 500MG TABLET is not known

Q. How does PYRA 500MG TABLET cause hyperuricemia and gout?

Following oral intake of PYRA 500MG TABLET, it gets converted in the body to pyrazinoic acid (active chemical form of PYRA 500MG TABLET). Pyrazinoic acid blocks the excretion of urates (salt form of uric acid) by the kidneys. This causes an increase in blood levels of uric acid (hyperuricemia). Excess uric acid accumulation between joints causes pain, swelling, redness and stiffness in joints (gout).

Want to share the information?

Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Gumbo T. Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1554-555.
  2. Chambers HF, Deck DH. Antimycobacterial Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 827.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1171-72.
  4. Drugs.com. Pyrazinamide. [Accessed 31 Mar. 2019] (online) Available from:External Link
  5. Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198 [Accessed 29 Mar. 2019] (online) Available from:External Link
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed 31 Mar. 2019] (online) Available from:External Link

Marketer details

Name: Kopran Ltd
Address: Parijat House, 1076, Dr. E. Moses Road, Worli, Mumbai - 400 018, Maharashtra (India).
Country of origin: India

NOT FOR SALE
We do not facilitate sale of this product at present

INDIA’S LARGEST HEALTHCARE PLATFORM

260m+
Visitors
31m+
Orders Delivered
1800+
Cities
Get the link to download App
Reliable

All products displayed on Tata 1mg are procured from verified and licensed pharmacies. All labs listed on the platform are accredited

Secure

Tata 1mg uses Secure Sockets Layer (SSL) 128-bit encryption and is Payment Card Industry Data Security Standard (PCI DSS) compliant

Affordable

Find affordable medicine substitutes, save up to 50% on health products, up to 80% off on lab tests and free doctor consultations.

LegitScript approved
India's only LegitScript and ISO/ IEC 27001 certified online healthcare platform

Know more about Tata 1mgdownArrow

Access medical and health information

Tata 1mg provides you with medical information which is curated, written and verified by experts, accurate and trustworthy. Our experts create high-quality content about medicines, diseases, lab investigations, Over-The-Counter (OTC) health products, Ayurvedic herbs/ingredients, and alternative remedies.

Order medicines online

Get free medicine home delivery in over 1800 cities across India. You can also order Ayurvedic, Homeopathic and other Over-The-Counter (OTC) health products. Your safety is our top priority. All products displayed on Tata 1mg are procured from verified and licensed pharmacies.

Book lab tests

Book any lab tests and preventive health packages from certified labs and get tested from the comfort of your home. Enjoy free home sample collection, view reports online and consult a doctor online for free.

Consult a doctor online

Got a health query? Consult doctors online from the comfort of your home for free. Chat privately with our registered medical specialists to connect directly with verified doctors. Your privacy is guaranteed.