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Premarin 0.3mg Tablet

Conjugated Estrogens (0.3mg)

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Premarin 0.3mg Tablet is a female sex hormone (estrogen). It is a part of female hormone replacement therapy which helps in treating estrogen deficiency symptoms like hot flushes (red and warm face) and vaginal dryness.

Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 22 May 2026 | 06:22 PM (IST)

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General Information

Contains

Conjugated Estrogens (0.3mg)

Marketer

Pfizer Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

In some cases, Premarin 0.3mg Tablet is also used to treat breast cancer and prostate cancer along with other anticancer medicines. It is to be taken at a fixed time(s) daily. The dose and duration will be decided by your doctor so that you get the right amount to control your symptoms. If you have missed a dose, take it as soon as you remember it. Do not skip any dose and finish the full course of treatment. The treatment should not be stopped abruptly without consulting your doctor as this may affect the potency of this medicine.

The most common side effects of this HRT are headaches, breast pain, irregular vaginal bleeding or spotting, abdominal cramps or bloating, nausea, vomiting, and hair loss. Some of the warning signs and symptoms that need immediate medical attention are breast lumps, unusual vaginal bleeding, dizziness and faintness, severe headaches, chest pain, shortness of breath, pains in your legs, etc.

Before taking this medicine, it is important to tell your doctor if you are taking or have recently taken any other medicines for the same disease or other diseases. Before you initiate with this HRT, you must consult the doctor if you have a history of unexplained vaginal bleeding or if you have ever had a blood clot in your legs or your lungs. If you are pregnant or breastfeeding, you should tell your doctor before taking this medicine. Your doctor may suggest you some diagnostic or laboratory tests to know the effects and side effects of this medicine on your body.

Uses of Premarin Tablet

Benefits of Premarin Tablet

Prevention of Post menopausal osteoporosis
Osteoporosis is a common condition that weakens bones, making them fragile and more likely to break. It often occurs in women after menopause (end of a woman's menstrual cycles) and is known as post-menopausal osteoporosis. Premarin 0.3mg Tablet helps to keep your bones strong and healthy and reduces the risk of osteoporosis. It also helps maintain bone density and reduces your risk of bone fracture. You should use this medicine as it is prescribed, and for as long as it is prescribed by your doctor.

Hormone replacement therapy
Hormone placement therapy (HRT) is a treatment to relieve symptoms of menopause such as hot flushes, night sweats, mood swings, vaginal dryness, and reduced sex drive. Since menopause can last for several years, this treatment can make a big improvement to your daily life and mood. Estrogen is one of two important hormones (the other is progesterone) used in this treatment. You should use this medicine as it is prescribed, and for as long as it is prescribed by your doctor.

Side effects of Premarin Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Premarin

Nausea
Breast pain
Hair loss
Irregular vaginal bleeding
Edema (swelling)
Vaginal spotting
Vaginal itching
Depression
Leg cramps
Abdominal cramp
Vaginal burning sensation

How to use Premarin Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Premarin 0.3mg Tablet may be taken with or without food.

How Premarin Tablet works

Premarin 0.3mg Tablet is a mixture of estrogens (female sex hormone). In women who are undergoing or have attained menopause, it prevents symptoms such as hot flushes, night sweats and mood swings. It also prevents the bones from becoming porous and fragile (osteoporosis).

Quick tips

You have been prescribed Premarin 0.3mg Tablet as a part of hormone replacement therapy to relieve symptoms of menopause.
It may also be used for preventing osteoporosis in postmenopausal women who are at high risk of fractures.
Take it at the same time everyday to help you remember to take it.
Inform your doctor if you experience any unusual vaginal bleeding or spotting, abnormal vaginal discharge or vaginal discomfort while taking Premarin 0.3mg Tablet.
It may increase the risk of breast cancer. Have regular breast examinations.
Stop taking this medicine and inform your doctor immediately if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, or changes in vision. These could be symptoms of a blood clot in a vein.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Premarin 0.3mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Premarin 0.3mg Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Premarin 0.3mg Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

SAFE

Premarin 0.3mg Tablet does not usually affect your ability to drive.

Kidney

CAUTION

Premarin 0.3mg Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

UNSAFE

Premarin 0.3mg Tablet is unsafe to use in patients with liver disease and should be avoided.

Interaction with drugs

Taking Premarin with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Tamoxifen (Oral Route)

Do not consume Tamoxifen with Conjugated Estrogens if you have or had breast cancer. If essential, consult your doctor. Conjugated Estrogens may reduce the efficacy of Tamoxifen.

Severe

Letrozole (Oral Route)

Do not consume Letrozole with Conjugated Estrogens if you have or had breast cancer. If essential, consult your doctor.

Severe

Fulvestrant (Injection Route)

Do not consume Fulvestrant with Conjugated Estrogens if you have or had breast cancer. If essential, consult your doctor. Conjugated Estrogens may reduce the efficacy of Fulvestrant.

Severe

Anastrozole (Oral Route)

Do not consume Anastrozole with Conjugated Estrogens if you have or had breast cancer. If essential, consult your doctor. Conjugated Estrogens may reduce the efficacy of Anastrozole.

Severe

Raloxifene (Oral Route)

Do not consume Raloxifene with Conjugated Estrogens. If concurrent use is essential, please consult your doctor. Conjugated Estrogens may reduce the efficacy of Raloxifene.

Frequently asked questions

What is Premarin 0.3mg Tablet and what is it used for?

Premarin 0.3mg Tablet contains a mixture of estrogens (a female sex hormone). It helps in treating estrogen deficiency symptoms like hot flushes (red and warm face), vaginal dryness in women. It is also used to prevent osteoporosis (thinning and weakening of bone) in postmenopausal women, who are at high risk of fractures and can not take other preventive medicines for osteoporosis.

When and how to take Premarin 0.3mg Tablet?

Take Premarin 0.3mg Tablet as per the advise by your doctor. However, you must try to take Premarin 0.3mg Tablet tablet at the same time of each day, to ensure the consistent levels of medicine in your body.

What if I miss to take Premarin 0.3mg Tablet?

If you miss a dose, you should take it as soon as possible. If the dose was missed by more than 12 hours, you should not take the missed dose and simply continue the usual dosing schedule.

What are the most common side effects which I may experience while taking Premarin 0.3mg Tablet?

The common side effects associated with Premarin 0.3mg Tablet are lower abdominal pain, periods pain, breast tenderness, endometrial hyperplasia (thickening of uterus lining) and vaginal discharge. Most of these symptoms are temporary. However, if they persist, check with your doctor as soon as possible.

Fact Box

Chemical Class

Steroid derivative

Habit Forming

Therapeutic Class

GYNAECOLOGICAL

Action Class

Estrogens

Related lab tests

Calcium

References

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 501.
Conjgated estrogen. Sandwich, Kent: Pfizer Limited; 2011 [revised Aug. 2016]. [Accessed 03 Apr. 2019] (online) Available from:
Gambacciani M, Levancini M. Hormone replacement therapy and the prevention of postmenopausal osteoporosis. Prz Menopauzalny. 2014 Sep;13(4):213-20. [Accessed 20 Feb. 2024] (online) Available from:
Conjugated oestrogens [Package leaflet: Information for the user]. County Kildare, Republic of Ireland: Pfizer Ireland Pharmaceuticals; 2023. [Accessed 20 Feb. 2024] (online) Available from:

User feedback

Patients taking Premarin 0.3mg Tablet

Once A Day

97%

Alternate Day

Thrice A Day

Twice A Day

What are you using Premarin Tablet for?

Hormone replacement therapy

69%

Post menopausal osteoporosis

23%

Others

How much was the improvement?

Poor

42%

Excellent

33%

Average

25%

What were the side-effects while using Premarin 0.3mg Tablet?

No Side Effect

67%

Breast enlargement

33%

How do you take Premarin Tablet?

With food

50%

With or without food

50%

Please rate Premarin 0.3mg Tablet on price

Average

50%

Not Expensive

50%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Pfizer Ltd
Address: The Capital, 1802, 18th Floor , Plot No. C-70, ‘G’ Block , Bandra Kurla Complex, Bandra East , Mumbai – 400051.

Vendor Details

Country of origin: Ireland
A licensed vendor partner from your nearest location will deliver Premarin 0.3mg Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

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Home

Gynaecological

Hormonal Contraceptives Systemic

Premarin 0.3mg Tablet

Premarin 0.3mg Tablet

Cash on delivery

Free Return

Expiry after

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Premarin Tablet

Benefits of Premarin Tablet

Side effects of Premarin Tablet

How to use Premarin Tablet

How Premarin Tablet works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Tamoxifen (Oral Route)

Letrozole (Oral Route)

Fulvestrant (Injection Route)

Anastrozole (Oral Route)

Raloxifene (Oral Route)

Frequently asked questions

What is Premarin 0.3mg Tablet and what is it used for?

When and how to take Premarin 0.3mg Tablet?

What if I miss to take Premarin 0.3mg Tablet?

What are the most common side effects which I may experience while taking Premarin 0.3mg Tablet?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Calcium

References

User feedback

Patients taking Premarin 0.3mg Tablet

What are you using Premarin Tablet for?

How much was the improvement?

What were the side-effects while using Premarin 0.3mg Tablet?

How do you take Premarin Tablet?

Please rate Premarin 0.3mg Tablet on price

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

Related/Popular tests