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Darunavir is combined with cobicistat/ low dose ritonavir, and used in combination with other antiretroviral (ART) drugs to treat human immunodeficiency virus (HIV) infection.

How it works

Darunavir belongs to a class of drugs called protease inhibitors. It binds to and inhibits the activity of protease enzyme of HIV activity, thereby interfering with the multiplication and spread of HIV infection in the body.

Common side effects

Numbness, Rash, Drowsiness, Diarrhoea, Altered taste, Fat accumulation, Increased glucose level in blood, Loss of strength, Stomach pain, Tingling sensation, Pain, Tingling sensation of extremity, Vomiting


Expert advice

  • Darunavir is not a cure for HIV infection and patients can still pass on HIV when taking this medicine.
  • Taking darunavir may cause a skin rash; contact your doctor whenever you develop a rash.
  • Caution is to be observed in patients taking raltegravir along with darunavir as it enhances the risk of developing rash by many folds.
  • Inform your doctor before taking this drug if you are an elderly patient ? 65 years of age, if you had liver disease including hepatitis B or C or have hemophilia or if you are allergic to sulfa drugs.
  • Tell your doctor if you have diabetes as darunavir can increase sugar levels in the blood.
  • Contact your doctor immediately if you notice any symptoms of infection (for example enlarged lymph nodes and fever), face changes in body fat like redistribution, accumulation or loss.

Frequently asked questions


Q. Does darunavir cause hair loss?
Darunavir doesn’t seem to have the potential for causing hair loss.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)