Medicine Overview of Pizorad Tablet
Pizorad 15mg Tablet is used in the treatment of type 2 diabetes
It is used in addition to diet and exercise to improve blood sugar control in adults with type 2 diabetes.
Weight gain, Blurred vision, Respiratory tract infection, Numbness, Bone fracture.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pizorad 15mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Pizorad 15mg Tablet is an anti-diabetic medication. It works by increasing the body's sensitivity to insulin, a natural substance that helps control blood sugar levels.
In Depth Information on Pizorad Tablet
Pizorad helps to control blood sugar level and avoids long-term complications.
You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Pizorad.
Full effect may be visible after several weeks of starting Pizorad.
Weight gain, headache, and swelling due to fluid build-up may occur.
- Notify your doctor if you experience shortness of breath, heart problems, or any abnormal swelling.
May not be suitable for patients with a history of heart failure or bladder cancer.
Pizorad Tablet related warnings
Taking pioglitazone with alcohol may affect blood glucose levels in patients with diabetes.
WEIGH RISKS VS BENEFITS
Pizorad 15mg Tablet may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Pizorad 15mg Tablet is probably safe to use during lactation.
Limited human data suggests that the drug does not represent a significant risk to the baby.
Monitor the breastfed baby’s blood sugar during treatment with Pizorad 15mg Tablet
Pizorad 15mg Tablet does not usually affect your ability to drive.
Pizorad 15mg Tablet is safe to use in patients with kidney disease. No dose adjustment of Pizorad 15mg Tablet is recommended.
Use of Pizorad 15mg Tablet is not recommended in patients undergoing dialysis.
Pizorad 15mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Pizorad 15mg Tablet may be needed. Please consult your doctor.
Use of Pizorad 15mg Tablet is not recommended in patients with severe liver disease.
If you miss a dose of Pizorad 15mg Tablet, skip it and continue with your normal schedule. Do not double the dose.
Frequently asked questions about Pizorad Tablet
No. Pizorad is an anti-diabetic medication. Blood thinners are the medicine that prevents the formation of a harmful blood clot. These include medicines like Aspirin, Heparin and Warfarin.
Q. Is Pizorad a diuretic?
No. Pizorad is not a diuretic. It is used in the treatment of Diabetes Mellitus. Diuretics are those medicine which increases urination.
Q. Can Pizorad used in Hepatitis B infection?
Some studies have shown that Pizorad may be helpful in preventing Hepatitis B Virus-associated Hepatocellular Cancer (Liver Cancer). However, these findings are still very preliminary and clear role has not been established.
Pizorad has been shown to inhibit Liver Cancer (HCC) recurrence in overweight Hepatitis C Virus-infected diabetic patients. It also improved insulin resistance (a state where the body is resistant to the effects and functions of the insulin hormone) in them.
Q. Can Pizorad used along with Vitamin D?
Studies indicate that Vitamin-D combined with Pizorad may be more effective in improving Bone Mineral Density and Bone Metabolism than Vitamin-D or Pizorad alone in the treatment of Diabetes Mellitus patients with kidney dysfunction (Diabetic Nephropathy).
Q. Can Pizorad be used along with sitagliptin?
Combination therapy with Sitagliptin and Pizorad leads to a substantial and sustained improvement in glycemic (blood sugar) control compared to the treatment with Pizorad alone. This is useful for patients who cannot tolerate Metformin or Sulfonylureas.
Recent evidence suggests that Pizorad may be beneficial in Alzheimer's disease (AD), decreasing the cognitive decline early in the disease process. However, larger studies are now in progress to establish the same.
Q. Can Pizorad and repaglinide combined in diabetes treatment?
For patients who previously failed oral antidiabetic therapy, the combination of Repaglinide and Pizorad have acceptable safety, with greater reductions of glycemic parameters (blood sugar levels) than using either agent alone.
Large population studies indicate that Pizorad is associated with an increased risk of bladder cancer. The absence of an association of bladder cancer with the other drug of the same class, Rosiglitazone, suggests that the increased risk is drug specific and not a class effect.
Q. Are Pizorad and rosiglitazone same?
Pizorad & Rosiglitazone both belong to a class of antidiabetics called Thiazolidinediones. Rosiglitazone has been removed from the market because using this drug was associated with increased risk of cardiovascular events like heart attack and stroke. This is not seen with Pizorad.
Q. Can Pizorad be used along with glimepiride in diabetes?
Pizorad when added to Glimepiride in Patients with Diabetes Mellitus, has been found to significantly reduce plasma lipid levels and significant improvement in blood pressure control related to a reduction in the insulin resistance.
No. Pizorad is not a steroid. It is an anti-diabetic medication which belongs to the class of thiazolidinediones.
Pizorad is an anti-diabetes drug used along with a proper diet and exercise program to control high blood sugar in patients with type 2 diabetes. Pizorad acts as an insulin sensitizer and decreases the extent of insulin resistance in the body too.
Pizorad cardiovascular safety profile compares favourably with that of Rosiglitazone. Pizorad has been found to be associated with bladder tumours but causality assessment has not been proved yet.
Pizorad increases the permeability of fluid in tiny blood vessels called capillaries. This results in easier movement of fluids across the membrane and their consequent accumulation, resulting in oedema (puffiness). Also, Pizorad causes increased sodium and water reabsorption from the kidney that contributes to the oedema.
The mechanism behind the link between Pizorad use and bladder cancer is still unknown. Studies have suggested that use of Pizorad for more than one year results in increased risk of development of tumour of the urinary bladder.
Pizorad can cause fluid retention and edema. Consequently, there is a lot of fluid in the body (fluid overload). As a result, it may precipitate heart failure (which worsens with fluid overload in those at risk).
Studies in animals have concluded that Pizorad improves the elasticity of the aortic wall ( the aorta is a large blood vessel that arises from the heart and supplies oxygenated blood to the rest of the body). This may be a mechanism by which it protects against atherosclerosis, but more studies are needed to confirm this.
The addition of Pizorad reduces daily insulin dosages, but study findings have not been consistent. Improvement of lipid profiles has also been weak with this combination therapy. Long-term studies are needed before any conclusions can be reached. Combination therapy should be primarily used for patients who achieve an insufficient reduction in blood sugar with insulin alone.
Q. Which is not safe in heart failure, Pizorad or rosiglitazone?
Pizorad & Rosiglitazone both belong to a class of antidiabetics called Thiazolidinediones. Rosiglitazone has been removed from the market because using this drug was associated with increased risk of cardiovascular events like heart attack and stroke. Pizorad can cause heart failure too, but the risk is less that that with Rosiglitazone. Both the medicines should be avoided in heart failure.
Fortunately, there are many alternatives to Pizorad- Metformin, Acarbose, Sitagliptin, Exenatide, Insulin or combination therapies of these medicines can be used.
Findings indicate that Pizorad treatment is associated with a reduced dementia risk in Diabetes mellitus patients. Prospective studies are needed to evaluate a possible neuroprotective effect in these patients in an ageing population.
Pizorad may be of use in infertile patients with polycystic ovary syndrome (PCOS) who are resistant to conventional ovulation induction such as by drugs like Clomiphene, Dexamethasone, or Metformin.
The use of Pizorad for plaque psoriasis treatment is controversial. Some studies revealed no effect of Pizorad 30 mg daily neither on the clinical response of moderate-to-severe psoriasis whereas others demonstrate that it could be considered as an efficacious and safe agent for the treatment of plaque psoriasis.
In a research study in a small number of autistic children, daily treatment with 30 or 60 mg Pizorad for 3–4 months induced apparent clinical improvement. Pizorad should be considered for further testing of therapeutic potential in autistic patients but as of now, autism is not an approved indication for Pizorad use.
Pizorad, either alone or as add-on therapy to conventional treatments, could clinically benefit patients of major depression according to a study.
A recent study shows that although Pizorad causes a significant decrease in blood sugar, HbA1C and lipid levels, it is associated with weight gain, which would limit its utility. It has not been shown to cause weight loss.
Pizorad has also been used to treat non-alcoholic steatohepatitis (fatty liver), but this use is presently considered experimental.
Pizorad reduces recurrent stroke and major vascular events in stroke patients with insulin resistance, prediabetes, and diabetes mellitus. However, its use as a preventive therapy requires more research.
Severely interacts with other drugs like
Taking Pizorad with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
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