Information about Pioglitazone

Pioglitazone Uses

Pioglitazone is used in the treatment of type 2 diabetes mellitus. It is used along with diet and exercise to improve blood sugar control in adults with type 2 diabetes.

How Pioglitazone works

Pioglitazone is an anti-diabetic medication. It works by increasing the body's sensitivity to insulin, a natural substance that helps control blood sugar levels.

Common side effects of Pioglitazone

Weight gain, Blurred vision, Respiratory tract infection, Numbness, Bone fracture
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MD (Pharmacology), MBBS
Last updated:
18 Feb 2020 | 11:51 AM (UTC)
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Available Medicine for Pioglitazone

PiozUSV Ltd
57 to ₹913 variant(s)
PioglitSun Pharmaceutical Industries Ltd
58 to ₹913 variant(s)
PiosysSystopic Laboratories Pvt Ltd
45 to ₹812 variant(s)
PioglarSun Pharmaceutical Industries Ltd
58 to ₹833 variant(s)
PionormMicro Labs Ltd
33 to ₹763 variant(s)
PathLupin Ltd
94 to ₹1323 variant(s)
GlitarisEris Lifesciences Ltd
57 to ₹883 variant(s)
PiokindMankind Pharma Ltd
60 to ₹792 variant(s)
PiomedIpca Laboratories Ltd
65 to ₹962 variant(s)
PiopodTorrent Pharmaceuticals Ltd
55 to ₹1002 variant(s)

Expert advice for Pioglitazone

  • Pioglitazone helps to control blood sugar level and avoid long-term complications.
  • You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Pioglitazone.
  • Take it only as per dose and duration suggested by your doctor. 
  • Full effects may be visible after several weeks of starting Pioglitazone. Keep taking it as prescribed by your doctor. 
  • Monitor your blood sugar level regularly while taking this medicine. 
  • Notify your doctor if you experience shortness of breath, heart problems, or any abnormal swelling.
  • Your doctor may monitor your liver function. Inform your doctor if you notice symptoms like abdominal pain, yellowing of eyes and loss of appetite. 

Frequently asked questions for Pioglitazone


Q. Can Pioglitazone cause weight gain?

Pioglitazone commonly causes weight gain which may be dose related. The reason for this weight gain could be fat accumulation. While, in heart failure patients it could be due to water retention in the body. Therefore, it is important to monitor weight in heart failure cases.

Q. Can Pioglitazone cause heart failure?

Pioglitazone can cause fluid retention which may aggravate or speed up heart failure. The doctor usually starts with the lowest available dose and increase the dose gradually while treating patients who have at least one risk factor for heart failure (previous heart attack, coronary artery disease, elderly). Heart failure is more common when Pioglitazone is used with insulin.

Q. Can you take Pioglitazone and metformin together?

Yes, Pioglitazone can be used with metformin where sufficient blood sugar management was not possible with metformin alone. This combination of medicines can be used in adult patients with type 2 diabetes mellitus and overweight patients with poor blood sugar control.

Q. What time of day should you take Pioglitazone?

It is usually prescribed once daily and can be taken at any time of the day but preferably at the same time each day. It can be taken with or without food. You should take Pioglitazone exactly as prescribed by your doctor.

Q. How long do I need to take Pioglitazone? Can I stop the medicine for some time?

Continue taking Pioglitazone as long as your doctor recommends to take it. Treatment for diabetes mellitus is long-term so you may have to take it life long. However, if you have to stop it then consult with your doctor who will suggest an alternative. Do not stop taking it without consulting your doctor as it may cause blood sugar levels to rise, which could be harmful to you.

Q. Can Pioglitazone cause bladder cancer?

Pioglitazone may increase the risk of bladder cancer, though it is very rare. Immediately consult your doctor if you experience blood in your urine, pain when urinating or a sudden need to urinate, during treatment with Pioglitazone. Pioglitazone should not be used in patients with a prior history of bladder cancer or having bladder cancer.

Q. Does Pioglitazone affect liver?

Yes, Pioglitazone may cause an increase in liver enzymes and treatment with Pioglitazone should be stopped if liver enzymes increase. Hence, levels of liver enzymes should be periodically checked while on treatment with Pioglitazone. Pioglitazone should not be prescribed to patients with liver disease.

Q. What kind of medicine is Pioglitazone? Is it like metformin?

Pioglitazone belongs to thiazolidinediones class of anti-diabetic medicines. It helps control blood sugar levels by improving how your body uses a hormone called insulin. This is done by helping your cells become more sensitive to the insulin your body makes.


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