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Piopil 30mg Tablet

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Psychotropics India Ltd

Composition for Piopil 30mg Tablet

iconPrescription Required

Primary uses of Piopil 30mg Tablet

Potentiallyunsafewith
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Alcohol
MRP
18.15
₹1.81/Tablet
10 tablets in 1 strip
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Medicine Overview of Piopil Tablet

uses

Uses of Piopil Tablet

Piopil 30mg Tablet is used in the treatment of type 2 diabetes. It is used in addition to diet and exercise to improve blood sugar control in adults with type 2 diabetes.
uses

Piopil Tablet side effects

Common

Weight gain, Blurred vision, Respiratory tract infection, Numbness, Bone fracture.

uses

How to use Piopil Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Piopil 30mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Piopil Tablet works

Piopil 30mg Tablet is an anti-diabetic medication. It works by increasing the body's sensitivity to insulin, a natural substance that helps control blood sugar levels.

In Depth Information on Piopil Tablet

Expert advice for Piopil Tablet

  • Piopil helps to control blood sugar level and avoids long-term complications.
  • You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Piopil.
  • Full effect may be visible after several weeks of starting Piopil.
  • Weight gain, headache, and swelling due to fluid build-up may occur.
  • Notify your doctor if you experience shortness of breath, heart problems, or any abnormal swelling.
  • May not be suitable for patients with a history of heart failure or bladder cancer.
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Piopil Tablet related warnings
Special precautions for Piopil Tablet
Alcohol
CAUTION
Taking pioglitazone with alcohol may affect blood glucose levels in patients with diabetes.
Pregnancy
WEIGH RISKS VS BENEFITS
Piopil 30mg Tablet may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Lactation
Piopil 30mg Tablet is probably safe to use during lactation. Limited human data suggests that the drug does not represent a significant risk to the baby.
Monitor the breastfed baby’s blood sugar during treatment with Piopil 30mg Tablet
Driving
SAFE
Piopil 30mg Tablet does not usually affect your ability to drive.
Kidney
SAFE
Piopil 30mg Tablet is safe to use in patients with kidney disease. No dose adjustment of Piopil 30mg Tablet is recommended.
Use of Piopil 30mg Tablet is not recommended in patients undergoing dialysis.
Liver
CAUTION
Piopil 30mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Piopil 30mg Tablet may be needed. Please consult your doctor.
Use of Piopil 30mg Tablet is not recommended in patients with severe liver disease.

What if you miss a dose of Piopil Tablet?uses

If you miss a dose of Piopil 30mg Tablet, skip it and continue with your normal schedule. Do not double the dose.

Patient Concerns

Frequently asked questions about Piopil Tablet

Frequently asked questions about Pioglitazone

No. Piopil is an anti-diabetic medication. Blood thinners are the medicine that prevents the formation of a harmful blood clot. These include medicines like Aspirin, Heparin and Warfarin.
Q. Is Piopil a diuretic?
No. Piopil is not a diuretic. It is used in the treatment of Diabetes Mellitus. Diuretics are those medicine which increases urination.
Q. Can Piopil used in Hepatitis B infection?
Some studies have shown that Piopil may be helpful in preventing Hepatitis B Virus-associated Hepatocellular Cancer (Liver Cancer). However, these findings are still very preliminary and clear role has not been established.
Piopil has been shown to inhibit Liver Cancer (HCC) recurrence in overweight Hepatitis C Virus-infected diabetic patients. It also improved insulin resistance (a state where the body is resistant to the effects and functions of the insulin hormone) in them.
Q. Can Piopil used along with Vitamin D?
Studies indicate that Vitamin-D combined with Piopil may be more effective in improving Bone Mineral Density and Bone Metabolism than Vitamin-D or Piopil alone in the treatment of Diabetes Mellitus patients with kidney dysfunction (Diabetic Nephropathy).
Q. Can Piopil be used along with sitagliptin?
Combination therapy with Sitagliptin and Piopil leads to a substantial and sustained improvement in glycemic (blood sugar) control compared to the treatment with Piopil alone. This is useful for patients who cannot tolerate Metformin or Sulfonylureas.
Recent evidence suggests that Piopil may be beneficial in Alzheimer's disease (AD), decreasing the cognitive decline early in the disease process. However, larger studies are now in progress to establish the same.
Q. Can Piopil and repaglinide combined in diabetes treatment?
For patients who previously failed oral antidiabetic therapy, the combination of Repaglinide and Piopil have acceptable safety, with greater reductions of glycemic parameters (blood sugar levels) than using either agent alone.
Large population studies indicate that Piopil is associated with an increased risk of bladder cancer. The absence of an association of bladder cancer with the other drug of the same class, Rosiglitazone, suggests that the increased risk is drug specific and not a class effect.
Q. Can Piopil be used along with glimepiride in diabetes?
Piopil when added to Glimepiride in Patients with Diabetes Mellitus, has been found to significantly reduce plasma lipid levels and significant improvement in blood pressure control related to a reduction in the insulin resistance.
No. Piopil is not a steroid. It is an anti-diabetic medication which belongs to the class of thiazolidinediones.
Piopil is an anti-diabetes drug used along with a proper diet and exercise program to control high blood sugar in patients with type 2 diabetes. Piopil acts as an insulin sensitizer and decreases the extent of insulin resistance in the body too.
Piopil cardiovascular safety profile compares favourably with that of Rosiglitazone. Piopil has been found to be associated with bladder tumours but causality assessment has not been proved yet.
Piopil increases the permeability of fluid in tiny blood vessels called capillaries. This results in easier movement of fluids across the membrane and their consequent accumulation, resulting in oedema (puffiness). Also, Piopil causes increased sodium and water reabsorption from the kidney that contributes to the oedema.
The mechanism behind the link between Piopil use and bladder cancer is still unknown. Studies have suggested that use of Piopil for more than one year results in increased risk of development of tumour of the urinary bladder.
Studies in animals have concluded that Piopil improves the elasticity of the aortic wall ( the aorta is a large blood vessel that arises from the heart and supplies oxygenated blood to the rest of the body). This may be a mechanism by which it protects against atherosclerosis, but more studies are needed to confirm this.
The addition of Piopil reduces daily insulin dosages, but study findings have not been consistent. Improvement of lipid profiles has also been weak with this combination therapy. Long-term studies are needed before any conclusions can be reached. Combination therapy should be primarily used for patients who achieve an insufficient reduction in blood sugar with insulin alone.
Findings indicate that Piopil treatment is associated with a reduced dementia risk in Diabetes mellitus patients. Prospective studies are needed to evaluate a possible neuroprotective effect in these patients in an ageing population.
Piopil may be of use in infertile patients with polycystic ovary syndrome (PCOS) who are resistant to conventional ovulation induction such as by drugs like Clomiphene, Dexamethasone, or Metformin.
The use of Piopil for plaque psoriasis treatment is controversial. Some studies revealed no effect of Piopil 30 mg daily neither on the clinical response of moderate-to-severe psoriasis whereas others demonstrate that it could be considered as an efficacious and safe agent for the treatment of plaque psoriasis.
In a research study in a small number of autistic children, daily treatment with 30 or 60 mg Piopil for 3–4 months induced apparent clinical improvement. Piopil should be considered for further testing of therapeutic potential in autistic patients but as of now, autism is not an approved indication for Piopil use.
Piopil, either alone or as add-on therapy to conventional treatments, could clinically benefit patients of major depression according to a study.
A recent study shows that although Piopil causes a significant decrease in blood sugar, HbA1C and lipid levels, it is associated with weight gain, which would limit its utility. It has not been shown to cause weight loss.
Piopil has also been used to treat non-alcoholic steatohepatitis (fatty liver), but this use is presently considered experimental.
Piopil reduces recurrent stroke and major vascular events in stroke patients with insulin resistance, prediabetes, and diabetes mellitus. However, its use as a preventive therapy requires more research.

Severely interacts with other drugs like

Taking Piopil with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Piopil with Trimethoprim
LIFE-THREATENING
Medicines with composition Trimethoprim: Tmp
Piopil with Paroxetine
SERIOUS
Piopil with Octreotide acetate
SERIOUS
Medicines with composition Octreotide acetate: Octotide, Octride, Sandostatin LAR, Octate, Varioct, Actide, Otide, Ferotide, Sandostatin
Piopil with Pancreatin
SERIOUS
Piopil with Insulin Glulisine
SERIOUS
Medicines with composition Insulin Glulisine: Apidra
Piopil with Insulin Lispro
SERIOUS
Medicines with composition Insulin Lispro: Humalog
SERIOUS
Medicines with composition Nicotinic acid / Niacin: Nicoglow
Piopil with Rasagiline
SERIOUS
Medicines with composition Rasagiline: Rasalect, Relgin, Rasipar
Piopil with Citalopram
SERIOUS
Medicines with composition Citalopram: Vocita, Olarc, Citopam, Cetadep, Cita, Topdep, Celica, Citalomine, Citalent, Citola, Cytop, Madam, Citalin, Citara
Piopil with Clonidine
SERIOUS
Medicines with composition Clonidine: Arkamin, Cloneon, Catapres
Piopil with Gemfibrozil
SERIOUS
Medicines with composition Gemfibrozil: Lopid, Regulipid
Piopil with Orlistat
SERIOUS
Piopil with Spironolactone
SERIOUS
Medicines with composition Spironolactone: Aldactone, Spilactone
Piopil with Dapoxetine
SERIOUS
Medicines with composition Dapoxetine: Actinex, DA Sutra, Stay Tal, Dapoxy, Dapnex, Duraject, Appynite, Ristor, Dejac, Xydap, Dapox, Ejalong, Prilyxet, Duralast
Piopil with Chlorthalidone
SERIOUS
Medicines with composition Chlorthalidone: Thiovas, Chlorfid, Lupiclor, Klorzid, Clovet, Thaloric, Thiaklor, Zione
Piopil with Pindolol
SERIOUS
Medicines with composition Pindolol: Visken
Piopil with Triamterene
SERIOUS
Medicines with composition Triamterene: Trymax
Piopil with Budesonide
SERIOUS
Medicines with composition Budesonide: Bunide, Budvent
Piopil with Fenofibrate
SERIOUS
Medicines with composition Fenofibrate: Lipicard, Trichek, Fenolip, Stanlip, Fenocard, Fibral, Fenodac, Fenofibric, Tgr, Trifeno, TG Chek, Fibrate
Piopil with Triamcinolone
SERIOUS
Medicines with composition Triamcinolone: Trilon, Stancort, Tricort, Triroid, Acort, Pericort, Comcort, Vetalog, Bonacort
Piopil with Metolazone
SERIOUS
Medicines with composition Metolazone: Metoz, Diurem, Zytanix, Zalat, Metadure, Lazon, Metolaz
Piopil with Lactase
SERIOUS
Medicines with composition Lactase: Cry NO
One of the following vendor pharmacies will deliver Piopil 30mg Tablet: ESY, NNP, 9T9, ANT, RSS, MLC, STA, TFP, PPR, MDO, HEX, BDN, NVL, HSP, EQN, PRN, GBL, RPP, NWP, NTB, GPT, MAK, SVS, JSL, TRP, DPP, QLF, UMP, AWS, USF, AMR, JVO, OLT, TNH, SDM, JVN, SPD, EVP, PEN, BSN, NVY, HAT, MDH, RKS, ENP, OIP, SRG, AVS, RSA, ABP, AYU, RHL, CLT, PLT, HZF, ZEL, JHC, PNT, BHS, SLN, SHC, TOM, SWA, OHM, VDH, NSL, BGS, SJP, THP, VNS, NDP, SHD, DVH, BTM, MAM, INC, LCC, AGT, BBS, EMB, ARD, RPI, ATL, BAL, HMP, DHR, MSD, ADT, GNC, BIO, LMS, BAP, BLE, UBL, GHR, PMA, GPP, HNP, BLS, NAS, PTI, JBT, VJS, SBA, ZVP, DZY, SGC, EPS, DGN, CHP, HTS, AAR, LHA, SMN, JIV, MPC, DAO, AAY, KIS, P2P, HIP, RDH, VRS, NXG, PWN, OWP, SSA, MAP, ATP, IPL, KMC, WHL, SAF, GTK, PVP, DHP, RJH, BHP, SBL, SCH, BMJ, FGH, RHW, DFP, IAD, AYM, SYN, NNH, HPC, SVH, RWP, MAX, DYG, SWP, MMS, RDR, QTM, HBV, GTC, KHC, WSI, KHH, HGI, RUS, SGH, ZPR, BHM

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