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Phenobarbitone 200mg Injection

Written By Dr. Lipika Khurana, PGDHHM, BDS
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS
Last updated on 26 Jan 2026 | 10:51 PM (IST)
Phenobarbitone 200mg Injection belongs to a class of medicines called barbiturates. It is used to treat and prevent epilepsy (seizures). They also have hypnotic properties. This means, they slow down the activity of the brain and can make you feel sleepy or dizzy.
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General Information

Contains

Phenobarbitone (200mg)

Marketer

Abbott

Storage

Store below 30°C
The content is shown in English
Phenobarbitone 200mg Injection image
Phenobarbitone 200mg Injection image

Product introduction

Phenobarbitone 200mg Injection is administered at a hospital or a clinical setting under the supervision of a doctor or a nurse. Get the injection regularly to maintain a consistent level of medicine in the body. Continue getting the injection, and do not stop it until the doctor says it is okay to stop.

Some common side effects of this medicine include nausea, diarrhea, hyperactivity, depression, confusion, decreased blood pressure, and fatigue. It may also cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Remember to consult your doctor if you notice severe rashes, especially accompanied by fever after taking this medicine. It should be noted that long-term use of this medicine can cause pain in joints.

Uses of Phenobarbitone Injection

Benefits of Phenobarbitone Injection

Epilepsy
Epilepsy is a neurological condition where sudden bursts of electrical activity in the brain cause repeated seizures. These seizures can vary from brief lapses in attention to intense muscle spasms and loss of consciousness. Phenobarbitone 200mg Injection helps reduce the frequency and intensity of these seizures, allowing the brain to function more steadily. It offers better seizure control, improves daily functioning, and helps people lead a more stable and independent life.

Side effects of Phenobarbitone Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Phenobarbitone
  • Sleepiness

How to use Phenobarbitone Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Phenobarbitone Injection works

Phenobarbitone 200mg Injection controls seizures or fits by increasing the action of GABA, a chemical messenger which suppresses the abnormal and excessive activity of the nerve cells in the brain.

Quick tips

  • Phenobarbitone 200mg Injection helps in treatment and prevention of seizures.
  • It may be habit-forming with long-term use.
  • Talk with your doctor if it stops working well. Do not take more than prescribed.
  • It may make you very sleepy. Don't drive or do anything that requires mental focus until you know how it affects you.
  • Inform your doctor if you notice pain in your joints or if you have a history of bone disease.
  • Get regular blood tests done to monitor the amount of medication in your body.
  • Talk to your doctor immediately if you notice skin rash accompanied with fever.
  • Do not stop taking the medication suddenly without talking to your doctor.

Safety advice

Alcohol

Alcohol

UNSAFE
Do not drink alcohol while you are taking this medicine. Phenobarbitone 200mg Injection may cause excessive drowsiness when taken with alcohol.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Phenobarbitone 200mg Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Phenobarbitone 200mg Injection may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Monitor the baby for sleepiness, skin rash, and feeding issues.
Driving

Driving

UNSAFE
Phenobarbitone 200mg Injection may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Phenobarbitone 200mg Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Use of Phenobarbitone 200mg Injection is not recommended in patients with severe kidney disease.
Liver

Liver

CONSULT YOUR DOCTOR
There is limited data available on the use of Phenobarbitone 200mg Injection in patients with liver disease.
Use of Phenobarbitone 200mg Injection is not recommended in patients with severe liver disease.

Interaction with drugs

Taking Phenobarbitone with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Ticagrelor (Oral Route)

Do not consume Ticagrelor with Phenobarbitone. Phenobarbitone may reduce blood levels of Ticagrelor.
Severe

Ranolazine (Oral Route)

Do not consume Ranolazine with Phenobarbitone. Phenobarbitone may reduce blood levels and efficacy of Ranolazine.
Severe

Irinotecan (Injection Route)

Do not consume Irinotecan with Phenobarbitone. If concurrent use is essential, please consult your doctor. Phenobarbitone may fasten the elimination of Irinotecan and its active form.
Severe

Sirolimus (Injection Route)

Do not consume Sirolimus with Phenobarbitone. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Phenobarbitone may reduce blood levels of Sirolimus.
Severe

Aprepitant (Oral Route)

Do not consume Aprepitant with Phenobarbitone. Phenobarbitone may reduce blood levels of Aprepitant.

Frequently asked questions

Phenobarbitone 200mg Injection is prescribed to control seizures or fits. Phenobarbitone 200mg Injection belongs to barbiturate group of medicines. In exceptional circumstances, it is also used to treat seizures that sometimes accompany a high fever in children.
If you forget to take a dose, take it as soon as you remember. However, if it is time for the next dose, skip the forgotten dose and take the next dose. Do not double the dose to make up for the forgotten dose.
Yes, Phenobarbitone 200mg Injection may cause addiction in patients with a history of alcoholism and drug abuse if they take it for a prolonged time. Therefore, Phenobarbitone 200mg Injection should be avoided in such patients.
Long-term use of phenobarbital can lead to changes in the soft tissues of the body. Symptoms include pain in the joints or thickening in areas such as the palm or the bottom of the foot. If you notice any changes of this kind, tell the doctor.
No, you should not stop taking Phenobarbitone 200mg Injection without consulting your doctor. Sudden withdrawal can cause sleeplessness, anxiety, tremor, dizziness, feeling sick, fits and delirium. The dose of Phenobarbitone 200mg Injection should be reduced gradually.
Swallowing more than the recommended doses may cause drowsiness, speech problems, jerky movements, jerky eye movements, loss of inhibition, reduced reflex response, low body temperature, low blood pressure and breathing problems. Contact your nearest hospital emergency services or your doctor immediately.
Phenobarbitone 200mg Injection causes folic acid deficiency which is responsible for certain types of anemia (megaloblastic anemia) in some patients. But if you take folic acid, then it may decrease the levels of Phenobarbitone 200mg Injection in your body. This may lead to seizures. Therefore, folic acid should be avoided.
You should take Phenobarbitone 200mg Injection for the duration advised by your doctor. This drug has a habit-forming effect, therefore, its long-term use is not recommended.
Yes, laboratory tests are available. If you feel excessively sleepy and experience tremor or balance issues or double vision, inform your doctor and get the levels checked.
Yes, suddenly stopping Phenobarbitone 200mg Injection can cause withdrawal symptoms which include sleeplessness, anxiety, tremor, dizziness, nausea, fits, and delirium.
Phenobarbitone 200mg Injection is prescribed to control seizures or fits. Phenobarbitone 200mg Injection belongs to barbiturate group of medicines. In exceptional circumstances, it is also used to treat seizures that sometimes accompany a high fever in children.
If you forget to take a dose, take it as soon as you remember. However, if it is time for the next dose, skip the forgotten dose and take the next dose. Do not double the dose to make up for the forgotten dose.
Yes, Phenobarbitone 200mg Injection may cause addiction in patients with a history of alcoholism and drug abuse if they take it for a prolonged time. Therefore, Phenobarbitone 200mg Injection should be avoided in such patients.
Long-term use of phenobarbital can lead to changes in the soft tissues of the body. Symptoms include pain in the joints or thickening in areas such as the palm or the bottom of the foot. If you notice any changes of this kind, tell the doctor.
No, you should not stop taking Phenobarbitone 200mg Injection without consulting your doctor. Sudden withdrawal can cause sleeplessness, anxiety, tremor, dizziness, feeling sick, fits and delirium. The dose of Phenobarbitone 200mg Injection should be reduced gradually.
Swallowing more than the recommended doses may cause drowsiness, speech problems, jerky movements, jerky eye movements, loss of inhibition, reduced reflex response, low body temperature, low blood pressure and breathing problems. Contact your nearest hospital emergency services or your doctor immediately.
Phenobarbitone 200mg Injection is useful in treating many kinds of seizures in children. It is often considered as the first choice to treat certain kinds of seizures in newborns. The child taking Phenobarbitone 200mg Injection treatment may develop problems with behavior and learning. Side effects are much more likely to be troublesome if high doses are given or if too high a dose is given at the beginning of the treatment. It may be necessary to increase the dose very slowly over several months.
Phenobarbitone 200mg Injection causes folic acid deficiency which is responsible for certain types of anemia (megaloblastic anemia) in some patients. But if you take folic acid, then it may decrease the levels of Phenobarbitone 200mg Injection in your body. This may lead to seizures. Therefore, folic acid should be avoided.
Yes, suddenly stopping Phenobarbitone 200mg Injection can cause withdrawal symptoms which include sleeplessness, anxiety, tremor, dizziness, nausea, fits, and delirium.
Yes, laboratory tests are available. If you feel excessively sleepy and experience tremor or balance issues or double vision, inform your doctor and get the levels checked.
You should take Phenobarbitone 200mg Injection for the duration advised by your doctor. This drug has a habit-forming effect, therefore, its long-term use is not recommended.

Fact Box

Chemical Class

Barbituric acid derivative

Habit Forming

Yes

Therapeutic Class

NEURO CNS

Action Class

Barbiturates

References

  1. McNamara JO. Pharmacotherapy of the Epilepsies. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 593-94.
  2. Porters RJ, Meldrum BS. Antiseizure Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 407.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1101-104.
  4. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Phenobarbital. [Updated 2018 Oct 31]. [Accessed 20 Feb. 2020] (online) Available from:
  5. Phrnobarbitone. Romford, Essex: Martindale Pharma; 2008 [revised 19 Jan. 2018]. [Accessed 22 Mar. 2019] (online) Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Abbott
Address: 16th Floor, Godrej BKC, Plot – C, “G” Block, Bandra-Kurla Complex, Bandra (East), Mumbai – 400 051, India

Vendor Details

Country of origin: India

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