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Paliris LA 75mg Injection

Paliperidone (75mg)
Genuine
Authenticity Assured
Prescription
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Paliris LA 75mg Injection is used in the treatment of schizophrenia (a mental disorder that can result in hallucinations or delusions and also adversely affects a person’s ability to think and behave) and mania. It helps control symptoms like hallucinations, mood swings, and disorganized thinking.

Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 23 Jan 2026 | 10:15 AM (IST)
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0.75 ml Injection
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Paliris LA 75mg Injection image
Paliris LA 75mg Injection image
Paliris LA 75mg Injection image
Paliris LA 75mg Injection image
Paliris LA 75mg Injection image
Paliris LA 75mg Injection image
Paliris LA 75mg Injection image

Product introduction

Paliris LA 75mg Injection is given under the supervision of a doctor. Get the injection regularly and at the same time each day to help maintain a consistent level of medicine in the body. This medication should not be stopped suddenly without talking to your doctor, as it may worsen your symptoms. However, discontinue this medicine immediately if you experience neuroleptic malignant syndrome (NMS), characterized by fever, muscle rigidity, and altered consciousness.


Some common side effects of this medicine include injection site reactions (pain, swelling, redness), tremors, anxiety, and weight gain. It also causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you.


You should be cautious if you are using this medicine, as it may increase the risk of developing diabetes, so it is better to monitor glucose regularly. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts while taking this medicine.

Uses of Paliris LA Injection

Benefits of Paliris LA Injection

Mania
Mania means extremely excited or elevated mood. Paliris LA 75mg Injection helps calm the mood and relax the nerves. This stabilises the mood and prevents the symptoms of mania from recurring again. Taking Paliris LA 75mg Injection will ensure that you have a better social life and are able to do daily activities more comfortably.

Side effects of Paliris LA Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Paliris LA
  • Abnormal involuntary movements
  • Dizziness
  • Injection site reactions (pain, swelling, redness)
  • Nystagmus (involuntary eye movement)
  • Sleepiness
  • Cogwheel rigidity
  • Tremors
  • Fast heart rate

How to use Paliris LA Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Paliris LA Injection works

Paliris LA 75mg Injection is an atypical antipsychotic. It works by affecting the levels of chemical messengers (dopamine and serotonin) to improve mood, thoughts, and behavior.

All substitutes for Paliris LA 75mg Injection

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

  • To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
  • Use caution while driving or doing anything that requires concentration as Paliris LA 75mg Injection can cause dizziness and sleepiness.
  • It may cause an increase in weight, blood sugar, cholesterol, and triglycerides (fat). Eat healthy, exercise, and monitor your levels regularly.
  • Monitor your blood sugar regularly as Paliris LA 75mg Injection can affect blood sugar levels.
  • Do not stop taking Paliris LA 75mg Injection without talking to your doctor first, as it may cause a worsening of symptoms.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Paliris LA 75mg Injection. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Paliris LA 75mg Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Paliris LA 75mg Injection may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

UNSAFE
Paliris LA 75mg Injection may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Paliris LA 75mg Injection should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Use of Paliris LA 75mg Injection is not recommended in patients with end-stage kidney disease.
Liver

Liver

CONSULT YOUR DOCTOR
There is limited data available on the use of Paliris LA 75mg Injection in patients with liver disease.
Limited information is available on the use of Paliris LA 75mg Injection in these patients. No dose adjustment is recommended in patients with mild to moderate liver disease.

Interaction with drugs

Taking Paliris LA with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Life-threatening

Amiodarone (Oral Route)

Do not consume Amiodarone with Paliperidone.
Life-threatening

Escitalopram Oxalate (Oral Route)

Do not consume Escitalopram Oxalate with Paliperidone.
Life-threatening

Haloperidol (Oral Route)

Do not consume Haloperidol with Paliperidone.
Life-threatening

Ondansetron (Oral Route)

Do not consume Ondansetron with Paliperidone.
Life-threatening

Iloperidone (Oral Route)

Do not consume Iloperidone with Paliperidone.

Frequently asked questions

Paliperidone gets converted to risperidone in the body and thus exerts similar actions
No, Paliris LA 75mg Injection is not a narcotic
Yes, Paliris LA 75mg Injection is an atypical antipsychotic
Paliris LA 75mg Injection is metabolized to its active metabolite risperidone by the CYP family of metabolizing enzymes
Yes, Paliris LA 75mg Injection is known to cause weight gain
Paliris LA 75mg Injection may cause priapism (prolonged and/or painful erection), which may contribute to erectile dysfunction. Please follow your doctor's advice regarding its use
Oral Paliris LA 75mg Injection may take 5 days to clear off from your body/system, whereas the injection may take around 4 to 8 months to clear off from your body/system.

Fact Box

Chemical Class

Pyridopyrimidines

Habit Forming

No

Therapeutic Class

NEURO CNS

Action Class

Atypical Antipsychotics

References

  1. Stahl SM, editor. Paliperidone. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 503-508.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1047-48.
  3. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Paliperidone. [Updated 2018 Oct 31]. [Accessed 20 Feb. 2020] (online) Available from:
  4. Paliperidone [Patient Information]. Titusville, NJ: Janssen Pharmaceuticals, Inc.; 2025. [Accessed 16 Mar. 2025] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Sun Pharmaceutical Industries Ltd
Address: Plot no 107/108,Namli block , Ranipool, East Sikkim 737135 || Khasra No. 1335-1340,Near EPIP- I, Vill - Bhatoli Kalan ,Baddi, Solan, Himachal Pradesh, 173205

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Paliris LA 75mg Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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