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Paliperidone is used in the treatment of schizophrenia (mental disorder in which patient interpret reality abnormally) and mania (abnormally elevated mood)

How it works

Paliperidone works by modulating the action of certain chemical messengers in the brain that affects thoughts and mood.

Common side effects

Nausea, Orthostatic hypotension (sudden lowering of blood pressure on standing), Parkinsonism, Pharyngolaryngeal pain, Rash, Abdominal pain, Abnormal involuntary movements, Agitation, Movement disorder, Anxiety, Joint pain, Atrioventricular block, Back pain, Blurred vision, Bradycardia, Bronchitis, Conduction disorder, Constipation, Cough, Depression, Diarrhoea, Dizziness, Dry mouth, Abnormal muscle tone, Ecg changes, Fatigue, Fever, Headache, Increased blood pressure, Decrease in body weight, Increase in body weight, Decreased appetite, Increased appetite, Indigestion, Influenza, Insomnia, Itching, Liver enzyme increased, Extremes of being happy or sad, Muscle pain, Nasal congestion, Sedation, Sinus inflammation, Tachycardia, Toothache, Tremor, Upper respiratory tract infection, Urinary tract infection, Vomiting, Weakness, Gastrointestinal discomfort

Available Medicine

Expert advice

  • You can take paliperidone with or without breakfast, however, same pattern to be followed during the entire treatment.
  • Inform your doctor if you have known cardiovascular disease or family history of QT prolongation and if you are taking medicines that may prolong the QT interval.
  • Discontinue and inform you doctor immediately if you experience Neuroleptic Malignant Syndrome (NMS), characterised by hyperthermia (fever), muscle rigidity, autonomic instability, altered consciousness, and elevated serum creatine levels.
  • Inform your doctor if you have a swallowing, stomach or intestinal disorder that reduces your ability to swallow or pass foods by normal bowel movements.
  • You may suffer from tardive dyskinesia characterized by rhythmical, involuntary movements, predominantly of the tongue and/or face. Inform you doctor if you experience such symptoms.
  • You may suffer from priapism (prolonged and/or painful erection), inform your doctor if you experience such symptoms.
  • Do not drive or operate machinery as paliperidone may have some nervous effects and may cause visual disturbances. 
  • If you are a patient with diabetes, or with schizophrenia, taking paliperidone may increase the risk of developing diabetes. You should monitor glucose regularly while on paliperidone treatment.
  • Seek immediate medical attention if the thoughts of suicide occur when on paliperidone therapy.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Frequently asked questions


Q. Is paliperidone the same as risperidone?
Paliperidone gets converted to risperidone in the body and thus exerts similar actions

Q. Is paliperidone a narcotic?
No, paliperidone is not a narcotic

Q. Is paliperidone an atypical antipsychotic?
Yes, paliperidone is an atypical antipsychotic

Q. How is paliperidone metabolized?
Paliperidone is metabolized to its active metabolite risperidone by the CYP family of metabolizing enzymes

Q. Does paliperidone cause weight gain?
Yes, paliperidone is known to cause weight gain

Q. Does paliperidone cause erectile dysfunction?
Paliperidone may cause priapism (prolonged and/or painful erection), which may contribute to erectile dysfunction. Please follow your doctor's advice regarding its use

Q. How long does paliperidone stay in your system?
Oral paliperidone may take 5 days to clear off from your body/system, whereas the injection may take around 4 to 8 months to clear off from your body/system.

Content on this page was last updated on 30 December, 2016, by Dr. Varun Gupta (MD Pharmacology)