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Paliperidone is used in the treatment of schizophrenia (mental disorder in which patient interpret reality abnormally) and mania (abnormally elevated mood)

How it works

Paliperidone work by modulating the action of certain chemical messengers in the brain that affects thoughts and mood.

Common side effects

Rash, Joint pain, Headache, Dizziness, Fainting, Back pain, Blurred vision, Increased appetite, Increased heart rate, Abnormal involuntary movements, Sinus inflammation, Muscle pain, Insomnia, Nasal congestion, Orthostatic hypotension (sudden lowering of blood pressure on standing), Abnormal muscle tone, Vomiting, Weakness, Sleepiness, Atrioventricular block, Nausea, Dry mouth, Abdominal pain, Extra pyramidal symptom, Indigestion, Extremes of being happy or sad, Agitation, Loss of appetite, Upper respiratory tract infection, Dyspepsia, Decreased white blood cell count, Parkinsonism, Influenza, Weight gain, Fatigue, Anxiety, Fever, Increased liver enzymes, Akathisia, Itching, Movement disorder, Urinary tract infection, Diarrhoea, Depression, Increased blood pressure, Tachycardia, Increase in body weight, Decreased appetite, Toothache, Cough, Rhinitis, Bronchitis, Sedation, Altered taste, Dystonia, Slow heart rate, Drowsiness, Urinary retention, Conduction disorder, Decrease in body weight, Increased saliva production, Pharyngolaryngeal pain, Respiratory tract infection, Ecg changes, Constipation, Urinary incontinence, Abnormal vision, Skin reaction, Gastrointestinal discomfort, Tremor, Seizure

Available Medicine

  • ₹10300
    Janssen Pharmaceuticals
    3 variant(s)
  • ₹33 to ₹129
    Torrent Pharmaceuticals Ltd
    4 variant(s)
  • ₹31 to ₹86
    Intas Pharmaceuticals Ltd
    3 variant(s)
  • ₹70 to ₹130
    Sun Pharmaceutical Industries Ltd
    3 variant(s)
  • ₹48 to ₹96
    Talent Healthcare
    3 variant(s)
  • ₹34 to ₹93
    Zydus Cadila
    3 variant(s)
  • ₹39 to ₹68
    Reliance Formulation Pvt Ltd
    2 variant(s)
  • ₹34 to ₹66
    Crescent Therapeutics Ltd
    2 variant(s)

Expert advice

  • You can take paliperidone with or without breakfast, however, same pattern to be followed during the entire treatment.
  • Inform your doctor if you have known cardiovascular disease or family history of QT prolongation and if you are taking medicines that may prolong the QT interval.
  • Discontinue and inform you doctor immediately if you experience Neuroleptic Malignant Syndrome (NMS), characterised by hyperthermia (fever), muscle rigidity, autonomic instability, altered consciousness, and elevated serum creatine levels.
  • Inform your doctor if you have a swallowing, stomach or intestinal disorder that reduces your ability to swallow or pass foods by normal bowel movements.
  • You may suffer from tardive dyskinesia characterized by rhythmical, involuntary movements, predominantly of the tongue and/or face. Inform you doctor if you experience such symptoms.
  • You may suffer from priapism (prolonged and/or painful erection), inform your doctor if you experience such symptoms.
  • Do not drive or operate machinery as paliperidone may have some nervous effects and may cause visual disturbances. 
  • If you are a patient with diabetes, or with schizophrenia, taking paliperidone may increase the risk of developing diabetes. You should monitor glucose regularly while on paliperidone treatment.
  • Seek immediate medical attention if the thoughts of suicide occur when on paliperidone therapy.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Frequently asked questions



Is paliperidone the same as risperidone?
Paliperidone gets converted to risperidone in the body and thus exerts similar actions


Is paliperidone a narcotic?
No, paliperidone is not a narcotic


Is paliperidone an atypical antipsychotic?
Yes, paliperidone is an atypical antipsychotic

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How is paliperidone metabolized?
Paliperidone is metabolized to its active metabolite risperidone by the CYP family of metabolizing enzymes


Does paliperidone cause weight gain?
Yes, paliperidone is known to cause weight gain


Does paliperidone cause erectile dysfunction?
Paliperidone may cause priapism (prolonged and/or painful erection), which may contribute to erectile dysfunction. Please follow your doctor's advice regarding its use


How long does paliperidone stay in your system?
Oral paliperidone may take 5 days to clear off from your body/system, whereas the injection may take around 4 to 8 months to clear off from your body/system.

Content on this page was last updated on 10 February, 2017, by Dr. Varun Gupta (MD Pharmacology)