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MMST, MBBS
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MD (Pharmacology), MBBS
Last updated:
19 Mar 2020 | 12:50 PM (IST)
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Norvelzo 3.5mg Injection

Prescription Required
SALT COMPOSITION
Storage
Store at room temperature (10-30°C)

Introduction

Norvelzo 3.5mg Injection is used in the treatment of multiple myeloma and mantle-cell lymphoma. It shows its working by stopping or slowing down the growth of cancer cells.

Norvelzo 3.5mg Injection is given as an injection by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Fatigue, nausea, vomiting, and loss of appetite are some common side effects of this medicine. You may be advised to drink plenty of fluids every day during the treatment. You should not drive or operate machinery as medicine may cause tiredness and dizziness. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels.

Before taking Norvelzo 3.5mg Injection, consult with your doctor if you have any liver, kidney, heart disease or bleeding problem.  It is important to consult a doctor if you develop symptoms like memory loss or trouble in thinking. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Norvelzo Powder for Injection

Side effects of Norvelzo Powder for Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Norvelzo

  • Low blood platelets
  • Fatigue
  • Peripheral neuropathy (tingling and numbness of feet and hand)
  • Psychiatric disturbances
  • Nausea
  • Vomiting
  • Loss of appetite
  • Fever
  • Anemia (low number of red blood cells)
  • Diarrhea
  • Decreased appetite
  • Decreased white blood cell count (neutrophils)
  • Constipation

How to use Norvelzo Powder for Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Norvelzo Powder for Injection works

Norvelzo 3.5mg Injection is an anti-cancer medication. It works by blocking or slowing the breakdown of proteins in cells. As a result, there is an increase in a number of proteins in the cancer cells leading to their death.

Safety Advice

Alcohol
UNSAFE
Norvelzo 3.5mg Injection may cause excessive drowsiness with alcohol.
Pregnancy
CONSULT YOUR DOCTOR
Norvelzo 3.5mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breastfeeding
UNSAFE
Norvelzo 3.5mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving
UNSAFE
Norvelzo 3.5mg Injection may cause side effects which could affect your ability to drive.
Norvelzo 3.5mg Injection might cause tiredness, dizziness, fainting, or blurred vision which may affect your ability to drive.
Kidney
CAUTION
Norvelzo 3.5mg Injection should be used with caution in patients with severe kidney disease. Dose adjustment of Norvelzo 3.5mg Injection may be needed. Please consult your doctor.
Limited information is available on the use of Norvelzo 3.5mg Injection in these patients.
Liver
CAUTION
Norvelzo 3.5mg Injection should be used with caution in patients with liver disease. Dose adjustment of Norvelzo 3.5mg Injection may be needed. Please consult your doctor.

What if you forget to take Norvelzo Powder for Injection?

If you miss a dose of Norvelzo 3.5mg Injection, please consult your doctor.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
No alternate brands found for this medicine

Quick Tips

  • Norvelzo 3.5mg Injection is given as an injection into veins or skin under the supervision of a healthcare professional.
  • Do not skip any dose and complete the course as suggested by your doctor.
  • Use an effective method of birth control to avoid pregnancy while taking this medication.
  • You may need to have blood tests to monitor your blood cells, platelets count, liver function and kidney function during treatment.
  • Inform your doctor immediately if you experience coughing, shortness of breath and swelling of feet. 

Fact Box

Chemical Class
Phenylalanine Derivatives
Habit Forming
No

Patient Concerns

arrow
Please tell me the interpretation of the attach report, if possible. Also guide for further treatment process.
Dr. Sanjay Singh Rai
Medical Oncology and Hematology
U r having multiple myeloma
Multiple myeloma can be cured or not
Dr. Rohan Khandelwal
Surgical Oncology
Yes, if diagnosed at the right stage
arrow
Do you have any questions related to Norvelzo 3.5mg Injection ?

FAQs

Q. Is Norvelzo 3.5mg Injection a chemotherapy/hormonal drug/ cytotoxic?

Norvelzo 3.5mg Injection is not a hormone. It is a chemotherapy/ cytotoxic drug used in the treatment of cancers including multiple myeloma and mantle cell lymphoma

Q. How does Norvelzo 3.5mg Injection work?

Norvelzo 3.5mg Injection belongs to the class of drugs called a proteasome inhibitor. It acts by blocking the action of proteasome, and affects the growth of cancerous (actively growing) cells

Q. Is Norvelzo 3.5mg Injection FDA approved?

Yes, Norvelzo 3.5mg Injection is approved by FDA

Q. Is Norvelzo 3.5mg Injection dialyzable?

Yes, Norvelzo 3.5mg Injection is dialyzable

Q. Is Norvelzo 3.5mg Injection toxic?

Norvelzo 3.5mg Injection can cause toxic effects if not given in appropriate dose although not everybody gets them

Q. Does Norvelzo 3.5mg Injection cause constipation?

Norvelzo 3.5mg Injection may cause side effects such as constipation.

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Disclaimer:

1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1742-43.
  2. Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 958.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 153-54.
  4. Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:External Link
  5. Bortezomib. Beerse Belgium: Janssen Pharmaceutica NV; [Accessed 26 Mar. 2019] (online) Available from:External Link
Country of Origin: India
Expires on or after: December, 2020

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