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Understanding the Test
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Dr. Shreya Gupta
BDS, MDS - Oral and Maxillofacial Pathology
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Dr. Ashish Ranjan
MBBS, MD (Pharmacology)
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Albumin/Globulin Ratio, Serum

You need to provide
Blood
This test is for
Male, Female

Understanding Albumin/Globulin Ratio, Serum


What is Albumin/Globulin Ratio, Serum?

 The Albumin/Globulin Ratio, Serum test to assess the balance of proteins (albumin and globulin) in the blood. This ratio can help in assessing various health conditions, including liver diseases, kidney diseases, and nutritional problems.

The Albumin/Globulin Ratio, Serum test is calculated by dividing the albumin level by the globulin level. Albumin and globulin are two types of proteins found in the blood. These proteins are essential for immune function and other physiological processes such as the body’s growth, development, and tissue repair. The Albumin/Globulin Ratio, Serum test can provide insights into various health conditions and is often included as part of routine tests or liver function tests.

Your doctor may suggest the Albumin/Globulin Ratio, Serum test if you experience symptoms such as fatigue, abnormal urination, unexplained swelling in legs and feet, yellowing of the skin and eyes, and allergy. This test may also be used to check the response of an undergoing treatment related to the liver and kidneys. Furthermore, it is also used to assess nutritional status, particularly protein intake and metabolism. 

Test result ranges are approximate and may differ slightly between different labs depending on the methodology and laboratory guidelines. Talk to your doctor about your specific test results. Narrate your complete medical history to help the doctor correlate your clinical and laboratory findings. The test results will help them determine your medical condition, make recommendations for lifestyle modifications such as diet and exercise, decide whether or not medication will be required to manage your overall health, and formulate your treatment plan.

What is Albumin/Globulin Ratio, Serum used for?

The Albumin/Globulin Ratio, Serum test is done:

  • As part of routine health checkups.
  • If you have symptoms of liver or kidney disease.
  • To monitor treatment response for existing liver and kidney diseases.
  • In case of a planned surgery.
  • In case of sudden/unexplained weight loss.
  • To check the nutritional status.

What does Albumin/Globulin Ratio, Serum measure?

The Albumin/Globulin Ratio, Serum test is performed if a liver or kidney disease is suspected. It quantifies the concentrations of two essential blood proteins, albumin and globulin. The test is a comparison figure in which albumin present in your body is divided by the amount of globulin to get the Albumin/Globulin) ratio. This ratio helps assess how well these two proteins are balanced and helps evaluate liver or kidney health.

References

  1. Busher JT. Serum Albumin and Globulin. In: Walker HK, Hall WD, Hurst JW, editors. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd ed. Boston: Butterworths; 1990. Chapter 101. [Accessed 22 Apr. 2024]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK204/External Link
  2. Moman RN, Gupta N, Varacallo M. Physiology, Albumin [Internet]. Treasure Island, Florida: StatPearls Publishing; 26 Dec. 2022 [Accessed 22 Apr. 2024]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459198/External Link
  3. Serum Albumin [Internet]. ScienceDirect; [Accessed 22 Apr. 2024]. Available from: https://www.sciencedirect.com/topics/medicine-and-dentistry/serum-albuminExternal Link
  4. Albumin (Blood) [Internet]. Rochester, NY: University of Rochester Medical Center; [Accessed 22 Apr. 2024]. Available from: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=albumin_bloodExternal Link
  5. Globulin [Internet]. ScienceDirect; [Accessed 22 Apr. 2024]. Available from: https://www.sciencedirect.com/topics/medicine-and-dentistry/globulin External Link
  6. Busher JT. Serum Albumin and Globulin. In: Walker HK, Hall WD, Hurst JW, editors. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition. Boston: Butterworths; 1990. Chapter 101. Available from: https://www.ncbi.nlm.nih.gov/books/NBK204/ External Link
  7. Nandedkar AK, Royal GC Jr, Nandedkar MA. Evaluation of albumin-globulin ratio to confirm the clinical stages of sarcoidosis. J Natl Med Assoc. 1986 Oct;78(10):969-71. PMID: 3783751; PMCID: PMC2571473. [Accessed 22 Apr. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2571473/ External Link

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