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Nitrest 5 Tablet

Written By Dr. Swati Mishra, BDS
Reviewed By Dr. Rajeev Sharma, MBA, MBBS
Last updated on 20 Feb 2026 | 02:08 PM (IST)
Nitrest 5 Tablet is used for short-term treatment of insomnia. It reduces sleep onset time and frequent awakening at night. This medicine improves sleep maintenance and therefore ensures sound sleep.
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General Information

The content is shown in English
Nitrest 5 Tablet image
Nitrest 5 Tablet image
Nitrest 5 Tablet image
Nitrest 5 Tablet image
Nitrest 5 Tablet image
Nitrest 5 Tablet image
Nitrest 5 Tablet image

Product introduction

Nitrest 5 Tablet should be taken on an empty stomach, preferably just before going to bed. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor as it is habit-forming. Do not stop taking it suddenly without talking to your doctor as it may worsen your symptoms.

Some common side effects of this medicine include memory loss, hallucinations, agitation, headache, vertigo, diarrhea, nausea, vomiting, and back pain. It may also cause fatigue, stomach pain, double vision, and depression. However, these are temporary and resolve on their own after some time. Please consult your doctor if these bother you or do not away.

Nitrest 5 Tablet also causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you, and do not take alcohol with it as it may worsen the dizziness. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, hallucinations, or suicidal thoughts while taking this medicine.

Before taking Nitrest 5 Tablet, inform your doctor about all other medicines that you are taking, so that your doctor can advise if taking this medicine is right for you. Consult your doctor before taking this medicine if you are suffering from any liver or kidney problems. You should avoid smoking and alcohol while using this medicine. Pregnant and breastfeeding mothers should not use this medicine. However, if the need arises, please consult your doctor before using it.

Uses of Nitrest Tablet

Benefits of Nitrest Tablet

Insomnia
Nitrest 5 Tablet is used to manage short-term sleep problems like difficulty falling asleep or waking up during the night. It helps promote faster sleep onset and longer, more restful sleep, so you can wake up feeling more refreshed. This can improve your energy, mood, and focus during the day.

Side effects of Nitrest Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Nitrest
  • Dizziness
  • Sleepiness
  • Diarrhea
  • Drowsiness

How to use Nitrest Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nitrest 5 Tablet is to be taken on an empty stomach.

How Nitrest Tablet works

Nitrest 5 Tablet belongs to a group of medicines called non-benzodiazepine hypnotics. It has hypnotic, sedative, and anticonvulsant (manages fits) properties. It works by binding of the GABAA receptor chloride channel macromolecular complex (a chemical messenger) that slows the activity of the nerve cells in the brain and helps fall asleep.

Quick tips

  • Your doctor has prescribed Nitrest 5 Tablet to help you fall asleep faster and sleep for longer.
  • It is best taken without food, as a high-fat meal can reduce its absorption and effect.
  • Take it 30 to 45 minutes before bedtime and only when you have time to sleep for at least 7 hours.
  • It makes you feel dizzy the next morning. Don't drive or do anything requiring concentration until you know how it affects you.
  • It does not affect total sleep time. However, it reduces sleep onset time and frequency of awakening at night.
  • Never share your medication with any other person who also has a sleep problem.
  • Inform your doctor if your sleep doesn’t improve after 7 to 10 days of treatment.
  • Stop taking medication and inform your doctor If you experience sleep driving or memory loss.
  • Do not stop taking medication suddenly as it may lead to anxiety, mood changes, and restlessness. 

Safety advice

Alcohol

Alcohol

UNSAFE
It is unsafe to consume alcohol with Nitrest 5 Tablet
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Nitrest 5 Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CAUTION
Nitrest 5 Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.
Driving

Driving

UNSAFE
Nitrest 5 Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Nitrest 5 Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
However, inform your doctor if you have any kidney disease.
Liver

Liver

CAUTION
Nitrest 5 Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.
Nitrest 5 Tablet is generally started at a low dose in patients with mild to moderate liver disease and is not recommended in patients with severe liver disease.

Interaction with drugs

Taking Nitrest with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Tramadol (Injection Route)

If concurrent use is essential, watch out for symptoms of Zolpidem side effects such as drowsiness, excessive sedation, tiredness, dizziness or slurred speech and consult your doctor if you experience them. They may adjust the dose of Zolpidem as per the observations. It is advised to avoid driving or undertaking other tasks requiring skill and alertness.
Severe

Tramadol (Oral Route)

If concurrent use is essential, watch out for symptoms of Zolpidem side effects such as drowsiness, excessive sedation, tiredness, dizziness or slurred speech and consult your doctor if you experience them. They may adjust the dose of Zolpidem as per the observations. It is advised to avoid driving or undertaking other tasks requiring skill and alertness.
Severe

Morphine (Oral Route)

If concurrent use is essential, watch out for symptoms of Zolpidem side effects such as drowsiness, excessive sedation, tiredness, dizziness or slurred speech and consult your doctor if you experience them. They may adjust the dose of Zolpidem as per the observations. It is advised to avoid driving or undertaking other tasks requiring skill and alertness.
Severe

Codeine (Oral Route)

If concurrent use is essential, watch out for symptoms of Zolpidem side effects such as drowsiness, excessive sedation, tiredness, dizziness or slurred speech and consult your doctor if you experience them. They may adjust the dose of Zolpidem as per the observations. It is advised to avoid driving or undertaking other tasks requiring skill and alertness.
Severe

Buprenorphine (Injection Route)

If concurrent use is essential, watch out for symptoms of Zolpidem side effects such as drowsiness, excessive sedation, tiredness, dizziness or slurred speech and consult your doctor if you experience them. They may adjust the dose of Zolpidem as per the observations. It is advised to avoid driving or undertaking other tasks requiring skill and alertness.

Frequently asked questions

Nitrest 5 Tablet produces a calming effect on the brain and induces sleep. This calming effect may be perceived as pleasant or feeling high by some individuals. On prolonged use, Nitrest 5 Tablet may also make an individual dependent such that they are not be able to sleep or function normally without taking it.
No, Nitrest 5 Tablet does not have paracetamol (acetaminophen) or aspirin in it.
No drug-drug interactions have been found Nitrest 5 Tablet taken with prednisone. However always consult with your doctor before taking these medicines together.
Nitrest 5 Tablet is used to treat insomnia, which may help ease anxiety in some patients, although doctors do not prescribe Nitrest 5 Tablet for anxiety alone because it does not work in the same manner as other sedatives anti-anxiety drugs
Yes, Nitrest 5 Tablet has abuse potential. However, it is more commonly seen in patients with a history of drug abuse, alcohol consumption, and drug addiction. Therefore, doctors should carefully take history of drug abuse from the patient. Moreover, patients with a history of drug abuse or addiction should be closely monitored during Nitrest 5 Tablet therapy.
The symptoms of Nitrest 5 Tablet overdose include drowsiness, confusion, problems with coordination, floppy muscles, slow or difficult breathing, and even coma (loss of consciousness for a period of time).
Nitrest 5 Tablet can make you drowsy during the daytime and also decrease your mental alertness. Therefore, you should not drive or operate heavy machinery until and unless you know how Nitrest 5 Tablet affects you. Do not drink alcohol while you are taking Nitrest 5 Tablet. Alcohol can make the side effects of Nitrest 5 Tablet even worse.
You should not take Nitrest 5 Tablet if you are allergic to it or any of its ingredients. You should also avoid Nitrest 5 Tablet if you have a history of depression, mental illness, or suicidal thoughts. A person having a history of drug or alcohol abuse or addiction, having kidney or liver disease, having a lung disease or breathing problems should avoid Nitrest 5 Tablet. Also, its consumption is not recommended if you are pregnant, planning to become pregnant, or breastfeeding.
No, do not take Nitrest 5 Tablet with or shortly after a heavy, high-fat meal. Nitrest 5 Tablet may not work well if it is taken with high-fat foods.
Nitrest 5 Tablet is used for short-term (2-4 weeks) treatment of insomnia (difficulty falling asleep). It should be taken exactly as prescribed by the doctor. The dose and duration of treatment should not be exceeded else it may lead to dependence (addiction towards medicine).
Yes, dry mouth is a common side effect of Nitrest 5 Tablet, whereas weight gain is less common with Nitrest 5 Tablet. If you experience weight gain, it could be due to increased appetite.
Nitrest 5 Tablet starts working as soon as you take it and may make you very sleepy. You may remain sleepy for some time after you take the medication. Plan to go to bed right after you take Nitrest 5 Tablet and to stay in bed for 7 to 8 hours. Do not take Nitrest 5 Tablet if you will be unable to go to bed right away and remain asleep for 7 to 8 hours after taking the medication.
Do not stop taking Nitrest 5 Tablet without talking to your doctor. If you suddenly stop taking Nitrest 5 Tablet, you may experience withdrawal symptoms such as unpleasant feelings, stomach and muscle cramps, vomiting, sweating, shakiness, and rarely, seizures.
You can improve your sleep by avoiding caffeine and nicotine, especially late in the day. Avoid exercise during the four hours before bedtime; daily exercise is beneficial to sleep, but can interfere if done close to bedtime. Avoid large meals in the evening. Avoid taking naps. Go to sleep and wake up at the same time each day. Keep the bedroom as dark as possible and maintain a comfortable temperature. Set aside a time to relax before bed and use relaxation techniques.
Insomnia is a common sleep disorder. People with insomnia experience trouble in falling asleep, staying asleep, or both. As a result, they may get too little sleep or have poor-quality sleep, and they may not feel refreshed after waking up.
Insomnia can be of two types- primary or secondary. In primary insomnia, the cause is not known. It can be triggered by life-style changes including long-lasting stress and emotional upset. Whereas, secondary insomnia can be caused due to various reasons such as certain medical conditions (depression, anxiety, post-traumatic stress disorder, Alzheimer's disease, and Parkinson's disease), medicines, sleep disorders, and substances (caffeine and other stimulants, tobacco and other nicotine products, and alcohol).

Fact Box

Chemical Class

Phenylimidazoles

Habit Forming

Yes

Therapeutic Class

NEURO CNS

Action Class

Non-Benzodiazepine Hypnotics (Z-Drugs)

References

  1. Mihic SJ, Harris RA. Hypnotics and Sedatives. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 467-68.
  2. Stahl SM, editor. Zolpidem. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 751-54.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1519-20.
  4. Chaves RG, Lamounier JA, et al. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 19 Mar. 2019] (online) Available from:
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User feedback

Once A Day
100%
Insomnia
84%
Others
16%
Excellent
62%
Average
38%
Dizziness
50%
Sleepiness
17%
No Side Effect
17%
Dental abnormality
17%
With food
57%
Empty stomach
29%
With or without food
14%
Average
39%
Not Expensive
33%
Expensive
28%
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Sun Pharmaceutical Industries Ltd
Address: Khasra No. 1335-1340,Near EPIP- I, Vill - Bhatoli Kalan ,Baddi, Solan, Himachal Pradesh, 173205 || Plot no 107/108,Namli block , Ranipool, East Sikkim 737135

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Country of origin: India
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