Nextrip 25mg Tablet
Prescription Required
Product introduction
Nextrip 25mg Tablet is a tricyclic antidepressant. Different doses of this medicine help in treating and preventing different problems such as depression, neuropathic pain, and migraine.
Nextrip 25mg Tablet is normally taken before bedtime because it can make you feel sleepy. It can be taken with or without food. The dose and how often you need to take it will be decided by your doctor so that you get the right amount to control your symptoms. The initial dose should be increased with great caution under close supervision. This medicine may not work straight away and it could be several weeks before you get the full effects.
How long you need to use it will depend on what you are taking it for, but it is important to continue taking this medication even if you feel well. Do not stop taking the medicine suddenly without talking to your doctor. Stopping the medicine suddenly can worsen your conditions or cause other symptoms. Your dose may be modified or gradually decreased before stopping the medication.
The most common side effects of this medicine include nausea, constipation, sweating, dry mouth, sleepiness, tremor, dizziness, headache, speech disorder, accommodation disorder, increased heart rate, orthostatic hypotension, and nasal congestion. It may also make you aggressive or confused and can lead to weight gain in some people.
This medicine is not addictive, but you can experience additional side effects (withdrawal symptoms) if you stop taking it suddenly. Most of the common side effects tend to be mild. Your doctor may be able to suggest ways of preventing or reducing side effects if they bother you or do not go away. Serious side effects associated with this medicine are rare.
Uses of Nextrip Tablet
Benefits of Nextrip Tablet
In Treatment of Migraine
Nextrip 25mg Tablet helps prevent migraines by changing the way that your nerves receive pain signals. By preventing and reducing the frequency of headaches, it can help you carry out your daily activities and have a better quality of life.
Side effects of Nextrip Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Nextrip
- Nausea
- Constipation
- Dryness in mouth
- Aggressive behavior
- Nasal congestion (stuffy nose)
- Sleepiness
- Dizziness
- Headache
- Decreased libido
- Fatigue
- Confusion
- Tremors
- Speech disorder
- Weight gain
- Taste change
- Paresthesia (tingling or pricking sensation)
- Abnormality of voluntary movements
- Loss of accommodation
- Micturition disorders
- Orthostatic hypotension (sudden lowering of blood pressure on standing)
- Erectile dysfunction
- Abnormal ECG
- Decreased sodium level in blood
How to use Nextrip Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nextrip 25mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
How Nextrip Tablet works
Nextrip 25mg Tablet contains Amitriptyline, a tricyclic antidepressant. It has anticholinergic and sedative properties. It prevents the reuptake, and hence the inactivation of neurotransmitters called noradrenaline and serotonin, that are present at the nerve terminals in our brain. Reuptake prevention of these monoamine neurotransmitters potentiate their action in the brain. This appears to be associated with the antidepressant activity and helps in regulating the mood. It also stops the transmission of pain signals from nerves to the brain thereby relieving neuropathic pain (pain from damaged nerves).
Safety advice
Alcohol
UNSAFE
It is unsafe to consume alcohol with Nextrip 25mg Tablet.
Pregnancy
CONSULT YOUR DOCTOR
Nextrip 25mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Nextrip 25mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Nextrip 25mg Tablet may cause side effects which could affect your ability to drive.
Nextrip 25mg Tablet may impair your alertness which may affect your ability to drive.
Nextrip 25mg Tablet may impair your alertness which may affect your ability to drive.
Kidney
SAFE IF PRESCRIBED
Nextrip 25mg Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Nextrip 25mg Tablet may not be needed in these patients. Please consult your doctor.
Liver
CAUTION
Nextrip 25mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Nextrip 25mg Tablet may be needed. Please consult your doctor.
Use of Nextrip 25mg Tablet is not recommended in patients with severe liver disease.
Use of Nextrip 25mg Tablet is not recommended in patients with severe liver disease.
What if you forget to take Nextrip Tablet?
If you miss a dose of Nextrip 25mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
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Quick tips
- It may take 4 to 6 weeks for Nextrip 25mg Tablet to start working. Keep taking it as prescribed.
- It may cause sleepiness. Take it at bedtime and do not drive or do anything requiring concentration until you know how it affects you.
- Avoid consuming alcohol when taking Nextrip 25mg Tablet as it may cause excessive sleepiness.
- Monitor your weight during the treatment as this medicine can cause weight gain and increased appetite.
- It may cause sudden drop in your blood pressure. Rise slowly if you have been sitting or lying down.
- Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
- Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when an antidepressant medicine is started or when the dose is changed.
Fact Box
Chemical Class
Dibenzocycloheptenes Derivative
Habit Forming
No
Therapeutic Class
NEURO CNS
Action Class
Tricyclic Antidepressants (TCAs)
Interaction with drugs
Taking Nextrip with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Concomitant use may cause a fatal increase in blood serotonin levels. Patients may experience agitation, increased body temperature, fast heartbeat, muscle rigidity, and loss of co
Concomitant use may cause an increase in blood serotonin levels. Patients may experience agitation, increased body temperature, fast heartbeat, muscle rigidity, and loss of coordin
Concomitant use may affect heart rhythm.
Do not consume Domperidone with Amitriptyline.
Concurrent use may cause serotonin syndrome.
Careful consideration is advised if you have epilepsy. Watch out for symptoms of serotonin syndrome, such as sedation, respiratory imp
Concurrent use may cause serious disturbance in heart rhythm.
If concurrent use is essential, watch out for symptoms such as sleepiness, dry mouth, impaired voluntary movements, w
Patient concerns
FAQs
What other lifestyle changes should I make to get maximum benefit of Nextrip 25mg Tablet?
Antidepressants, including Nextrip 25mg Tablet, are just one of several approaches to treat depression. Certain lifestyle changes can help you get maximum benefit of Nextrip 25mg Tablet and help you recover fast. Keeping active and eating a healthy diet can make a significant difference to how quickly you recover from depression. Think positively and try to discuss your thoughts with others to reduce stress. Practice yoga or take up a hobby. Ensure that you have a sound sleep to calm your mind. Stay away from smoking or alcohol consumption as these will only worsen your depression. Take your medicines as prescribed even if you start feeling better.
Is there anything I need to be careful about while on therapy with Nextrip 25mg Tablet?
Nextrip 25mg Tablet may cause drowsiness and dizziness, especially in the beginning of the treatment. So, avoid driving or using machinery until you know how the medicine affects you. Also, it is not advisable to drink alcohol during treatment with this medicine as it might increase sleepiness.
Can the use of Nextrip 25mg Tablet affect my sex life?
Yes, Nextrip 25mg Tablet can affect sex life in both men and women. It may cause decreased sexual desire or you may experience discomfort during intercourse. Men may experience inability to develop or maintain an erection during sexual activity and may be unable to have an orgasm. If you notice these symptoms, do not stop taking the medicine but consult your doctor.
I have been taking Nextrip 25mg Tablet for depression since a week and recently I have been wanting to harm myself. What should I do? Is it because of the medicine?
You should immediately consult your doctor or go to the hospital. Your suicidal tendencies may have increased because of your disease or the medicine. Generally, Nextrip 25mg Tablet takes about 2 weeks to show its effect but may take longer. Therefore, when you start taking Nextrip 25mg Tablet, you may have thoughts about killing or harming yourself. This is more common in people who previously had suicidal tendencies or are young adults (less than 25 years old). However, the effect of medicine is different for every individual.
Can Nextrip 25mg Tablet cause urinary problems?
Yes, Nextrip 25mg Tablet can cause urinary problems. It is more commonly seen in elderly patients who are more than 65 years old. The patient may face difficulty in passing urine which can further lead to a urinary tract infection. Consult your doctor immediately if you develop these symptoms.
If my pain is not relieved, can I take more than the recommended dose?
No, you should use Nextrip 25mg Tablet strictly as prescribed by the doctor. If the dose exceeds, you may develop drowsiness, confusion, difficulty in speech, dry mouth, tiredness, difficulty in walking, fever, difficulty in breathing, blue discoloration of the skin and decreased heartbeat. Your pain may not be relieved because Nextrip 25mg Tablet takes about 2 weeks to show its effect, but it may take longer in some cases. The duration of treatment can differ from individual to individual. Consult your doctor if your symptoms are not relieved.
Does Nextrip 25mg Tablet cause any effect on pregnancy or the newborn?
Do not take Nextrip 25mg Tablet during pregnancy unless recommended by the doctor. If you take this medicine during the last trimester of the pregnancy, the newborn may develop symptoms such as irritability, rigidity, irregular body movements, irregular breathing, poor drinking, loud crying, difficulty in urinating and constipation.
I have been prescribed Nextrip 25mg Tablet for pain. When will I start feeling better?
You may start feeling better after 2 weeks of starting Nextrip 25mg Tablet. However, it may take 4-6 weeks to see the full benefits of the medicine.
Can I stop taking Nextrip 25mg Tablet when my pain is relieved?
No, do not stop taking Nextrip 25mg Tablet even if the pain is relieved. You should use Nextrip 25mg Tablet as advised by the doctor. Stopping the medicine suddenly may cause unpleasant symptoms like headache, feeling unwell, sleeplessness and irritability. Consult your doctor for the duration of the treatment since the dose of Nextrip 25mg Tablet needs to be reduced gradually.
How long does Nextrip 25mg Tablet take to work?
You may see an improvement in your symptoms after a couple of weeks, although it usually takes between 4 and 6 weeks before you feel the benefits. Do not stop taking Nextrip 25mg Tablet after 1 or 2 weeks just because you feel it is not helping your symptoms. Give the medicine at least 6 weeks to work.
How will Nextrip 25mg Tablet make me feel?
Antidepressants like Nextrip 25mg Tablet help to gradually lift your mood. You may notice that you sleep better and are less anxious. You may worry less about little things that used to bother you. Nextrip 25mg Tablet will not make you feel excessively or unusually happy. It will help you feel like yourself again.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Stahl SM, editor. Amitriptyline. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 25-30.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 58-59.
- Amitriptyline. Princeton: Sandoz Inc; 2014. [Accessed on 19 Mar. 2019] (online) Available from:
- Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Amitriptyline. [Updated 2018 Oct 31]. [Accessed 19 Feb. 2020] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:
- Amitriptyline Hydrochloride [Drug Label]. Ahmedabad, Gujarat: Intas Pharmaceuticals Limited; 2016. [Accessed 25 Jul. 2024] (online) Available from:
Marketer details
Name: Nexus Biotech
Address: NEXUS HOUSE # 19, 1ST FLOOR & 2ND FLOOR, 6TH MAIN, HANUMANTH NAGAR 2ND BLOCK, BSK 1st STAGE, 50 FT ROAD, Bangalore - 560050, Karnataka, India
Country of origin: India
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