MTX 5mg Tablet

Written By Dr. Lipika Khurana, PGDHHM, BDS

Reviewed By Dr. Mekhala Chandra, MD, MBBS

Last updated on 25 Nov 2025 | 03:05 PM (IST)

MTX 5mg Tablet is a medicine used for the treatment of cancer in various parts of the body. It is also used to treat rheumatoid arthritis, severe and uncontrolled psoriasis, and Crohn’s disease. It works by slowing the growth of abnormal cells and reducing immune system activity in autoimmune conditions.

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MTX 5mg Tablet

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Methotrexate (5mg)

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General Information

Contains

Methotrexate (5mg)

Marketer

Nexgen Rx Life Science Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

MTX 5mg Tablet may be used alone or in combination with other medicines. You should take it exactly as your doctor has advised. Taking too much of it can cause serious side effects. It may take several weeks or months for you to see or feel the benefits, but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine are ulcerative stomatitis, hair loss, low blood cell count, increased liver enzymes, nausea, and abdominal distress. Your doctor may advise you to take folic acid to reduce some of these. If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects.

MTX 5mg Tablet may lower your ability to fight infections and lead to problems with your blood, liver, or kidneys. Your doctor may perform several tests, such as blood tests, X-rays, and physical examinations, both before and during the treatment with this medicine to check for these problems.

Before taking it, tell your doctor if you have problems related to the stomach, liver, or kidneys, or are taking any medicines to treat infections. Many other medicines can affect or be affected by this medicine, so let your doctor know about all your medications. This medicine is not recommended during pregnancy or while breastfeeding, as it may harm the baby. You should avoid consuming alcohol while taking this medicine, as it may increase your risk of liver damage.

Uses of MTX Tablet

Benefits of MTX Tablet

Treatment of Cancer
MTX 5mg Tablet works by slowing the growth of cancer cells in the body. It is used to treat a wide range of cancers, such as acute leukemias, non-Hodgkin’s lymphoma, and solid tumors found in the breast, lung, bladder, head, and neck, as well as cervical, ovarian, and testicular cancer. It may be given alone or in combination with other medicines.

Treatment of Rheumatoid arthritis
MTX 5mg Tablet is typically used to treat severe rheumatoid arthritis when other treatments have not been effective. As a second-line treatment, it works by suppressing the immune system, which helps reduce inflammation, pain, stiffness, and improves joint function. Follow your doctor’s instructions carefully, taking it exactly as prescribed, and for the full duration. It may take several months to show full effects. Do not take more than the prescribed dose.

Treatment of Psoriasis
MTX 5mg Tablet belongs to a group of medicines called antimetabolites. It may be used to treat severe psoriasis when other treatments have not worked. Psoriasis is a condition where the skin cells in the body grow too quickly. MTX 5mg Tablet works by killing these fast-growing cells. It is potent and very toxic medicine and you should discuss the risks and benefits with your doctor. Take it exactly as prescribed and for as long as it is prescribed to get the most benefit. DO NOT take more than you should. It may take several months to become fully effective. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Treatment of Crohn’s disease
Crohn’s disease is a chronic (long-term) inflammatory disease of the intestines. The most common symptoms are diarrhea and pain in the abdomen. MTX 5mg Tablet helps reduce the inflammation, relieve the symptoms, and prevent them from coming back.

Side effects of MTX Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of MTX

Nausea
Abdominal pain
Ulcerative stomatitis
Decreased blood cells (red cells, white cells, and platelets)

How to use MTX Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. MTX 5mg Tablet may be taken with or without food.

How MTX Tablet works

MTX 5mg Tablet inhibits enzymes (dihydrofolate reductase), prevents cell division, and leads to anti-inflammatory actions. MTX 5mg Tablet kills cancer cells by preventing them from making DNA. MTX 5mg Tablet can help control psoriasis by retarding the production of skin cells and suppressing inflammation. MTX 5mg Tablet may treat rheumatoid arthritis by suppressing the immune system, preventing it from attacking the body's cells. This helps reduce the inflammation that causes swollen and stiff joints in rheumatoid arthritis or damage to the intestine in Crohn's disease.

All substitutes for MTX 5mg Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Drink plenty of liquids to stay hydrated while taking this medication.
Take folic acid if advised by your doctor. This will help lessen the side effects of this medicine.
MTX 5mg Tablet may take from weeks to months for MTX 5mg Tablet to work. Keep taking the medication as prescribed.
Your doctor may get regular blood tests done to monitor your kidney function, liver function, and the level of blood cells in your blood.
Avoid drinking alcohol while taking this medicine, as it may increase the risk of side effects.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with MTX 5mg Tablet

Pregnancy

UNSAFE

MTX 5mg Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

UNSAFE

MTX 5mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

CONSULT YOUR DOCTOR

It is not known whether MTX 5mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

CAUTION

MTX 5mg Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Regular monitoring of kidney function test is advised while you are taking this medicine.

Liver

CAUTION

MTX 5mg Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking MTX with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Filgrastim (Injection Route)

Do not consume Filgrastim from 24 hours before or 24 hours after taking Methotrexate. Please consult with your doctor. Methotrexate may reduce the efficacy of Filgrastim.

Severe

Acitretin (Oral Route)

Avoid concurrent use, please consult with your doctor.

Severe

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route)

Do not use Methotrexate with Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted). If essential, please consult your doctor. Methotrexate may reduce efficacy of Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted).

Severe

Phenytoin (Oral Route)

Please consult with your doctor. Doctor may monitor kidney and liver function.

Severe

Phenytoin (Injection Route)

Please consult with your doctor. Doctor may monitor kidney and liver function.

Frequently asked questions

Can MTX 5mg Tablet cause mouth ulcers?

Yes, MTX 5mg Tablet can cause a sore mouth and mouth ulcers as side effects in some cases. Taking folic acid along with MTX 5mg Tablet may help in reducing the ulcers. Ask your doctor if the dose can be reduced, as dose reduction may further help in reducing the ulcers.

Why do I have to take folic acid with MTX 5mg Tablet?

Folic acid is required to make new cells in the body, and MTX 5mg Tablet decreases the folic acid levels in the body. Folic acid can help reduce some of the side effects of MTX 5mg Tablet, such as mouth ulcers, hair loss, nausea, heartburn, abdominal pain, fatigue, anemia, and liver problems.

Why do I need to take regular blood tests while taking MTX 5mg Tablet?

Regular blood tests will help your doctor to check your response to MTX 5mg Tablet and monitor you for side effects. You will need to regularly check your liver function and your blood counts (white blood cells, red blood cells, and platelets). Your doctor may also order additional tests depending on the results.

Can MTX 5mg Tablet use make me more prone to infections?

MTX 5mg Tablet may decrease the activity of your immune system. As a result, you may develop serious infections. There have been rare reports that suggest the occurrence of serious lung infections with the use of MTX 5mg Tablet. If you have an active infection, MTX 5mg Tablet should be used with extreme caution.

Can MTX 5mg Tablet affect fertility?

Yes, MTX 5mg Tablet may affect fertility in both males and females. It may cause a decrease in sperm count in males and menstrual disturbances in females. No need to worry; these effects are reversible and disappear once the therapy is discontinued.

What to do if I am planning to become pregnant and my husband is taking MTX 5mg Tablet?

You should avoid pregnancy if your husband is taking MTX 5mg Tablet. Also, it is advised that pregnancy should be further avoided for a minimum of 3 months after the therapy, as it can lead to serious fetal abnormalities.

Fact Box

Chemical Class

Glutamic acid derivative

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Antimetabolite- Methotrexate

Related lab tests

Anti Saccharomyces Cerevisiae (ASCA), IgA

Anti Saccharomyces Cerevisiae (ASCA), IgG

Rheumatoid Factor - Agglutination

Rheumatoid Factor - Turbidometry

Rheumatoid Factor IgG Antibody

References

Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 944-46.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 887-90.
Methotrexate [Prescribing Information]. Eatontown, NJ: West-Ward Pharmaceuticals Corp.; 2020. [Accessed 19 Apr. 2023] (online) Available from:
Methotrexate [Product Label]. New York, NY: Pfizer Inc.; 2022. [Accessed 19 Apr. 2023] (online) Available from:
Methotrexate [Drug Label]. Sandton, South Africa: Pfizer Laboratories (Pty) Ltd.; 2022 [Accessed 19 Apr. 2023] (online) Available from:
Walfish AE, Companioni RA. Drugs for Inflammatory Bowel Disease. [Updated Sep. 2022]. [Accessed 19 Apr. 2023] (online) Available from:
Crohn's & Colitis, UK. Methotrexate [Information Sheet]. [Accessed 19 Apr. 2023] (online) Available from:
Methotrexate [Prescribing Information]. Berkeley Heights, NJ: Hikma Pharmaceuticals USA Inc.; 2023. [Accessed 26 Feb. 2025] (online) Available from:

User feedback

Patients taking MTX 5mg Tablet

Once A Week

73%

Twice A Week

14%

Once A Day

Alternate Day

What are you using MTX Tablet for?

Others

50%

Rheumatoid arthritis

50%

How much was the improvement?

Average

100%

What were the side-effects while using MTX 5mg Tablet?

No Side Effect

100%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Nexgen Rx Life Science Pvt Ltd
Address: PLOT NO-9,11&11A(1ST FLOOR), BALAJI COMPOUND,K NO -1218 , SIHANI CHUNGI, MEERUT ROAD., GHAZIABAD,(U.P) INDIA.

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

MTX 5mg Tablet

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General Information

Contains

Marketer

Storage

Product introduction

Uses of MTX Tablet

Benefits of MTX Tablet

Side effects of MTX Tablet

How to use MTX Tablet

How MTX Tablet works

All substitutes for MTX 5mg Tablet

Noltrexate 5mg Tablet

Folitrax 5 Tablet

Oncotrex 5 Tablet

Vibzi 5mg Tablet

MEXate 5 Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Filgrastim (Injection Route)

Acitretin (Oral Route)

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route)

Phenytoin (Oral Route)

Phenytoin (Injection Route)

Frequently asked questions

Can MTX 5mg Tablet cause mouth ulcers?

Why do I have to take folic acid with MTX 5mg Tablet?

Why do I need to take regular blood tests while taking MTX 5mg Tablet?

Can MTX 5mg Tablet use make me more prone to infections?

Can MTX 5mg Tablet affect fertility?

What to do if I am planning to become pregnant and my husband is taking MTX 5mg Tablet?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Anti Saccharomyces Cerevisiae (ASCA), IgA

Anti Saccharomyces Cerevisiae (ASCA), IgG

Rheumatoid Factor - Agglutination

Rheumatoid Factor - Turbidometry

Rheumatoid Factor IgG Antibody

References

User feedback

Patients taking MTX 5mg Tablet

What are you using MTX Tablet for?

How much was the improvement?

What were the side-effects while using MTX 5mg Tablet?

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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