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Melocure 10mg Tablet

Melatonin (10mg)
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Melocure 10mg Tablet is a medicine used in the treatment of insomnia and jet lag (a sleep disorder due to frequent travel to different time zones). It reduces jet lag symptoms such as irritability, indigestion, daytime tiredness, and sleep disturbances.

Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 07 Apr 2026 | 02:54 PM (IST)
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General Information

The content is shown in English
Melocure 10mg Tablet image
Melocure 10mg Tablet image

Product introduction

Melocure 10mg Tablet helps to synchronize the body’s biological day-night rhythm. It should be taken either 2 hours before or 2 hours after food, preferably at bedtime. However, it is advised to take it at a fixed time each day to maintain a consistent level of medicine in the blood. You should never skip any doses and finish the full course of treatment even if you feel better. This medicine should not be stopped suddenly without talking to your doctor.

Some common side effects of this medicine include headache and drowsiness. It even causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. It is important to note that this medicine should not be used for daily naps.

Consult your doctor before taking this medicine if you are suffering from any liver or kidney problems. You should avoid smoking and alcohol while using this medicine. Pregnant and breastfeeding mothers should not use this medicine. However, if the need arises, please consult your doctor before using it.

Uses of Melocure Tablet

Benefits of Melocure Tablet

Treatment of Insomnia
Insomnia is a condition where a person has difficulty falling asleep or staying asleep. Melocure 10mg Tablet is often used to support better sleep in individuals facing this issue. It helps regulate the body’s natural sleep-wake cycle, making it easier to fall asleep at night and improving overall sleep quality without causing grogginess the next day.
Treatment of Jet lag
Jet lag occurs when traveling across time zones disrupts the body's internal clock, leading to sleep disturbances and fatigue. Melocure 10mg Tablet can help reset this internal clock more quickly by signaling to the body that it is time to sleep, thus reducing the time it takes to adapt to a new schedule and improving alertness during travel.

Side effects of Melocure Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Melocure
  • Headache
  • Sleepiness

How to use Melocure Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Melocure 10mg Tablet is to be taken on an empty stomach.

How Melocure Tablet works

Melatonin is a hormone produced by the body that synchronizes the body’s biological day-and-night rhythm. The biological rhythm can be disturbed by travelling across time zones. This is known as jet lag. The symptoms and their severity vary between individuals, but are generally worse and last longer the more time zones are crossed. Melocure 10mg Tablet can help restore the normal day-and-night rhythm and reduce the symptoms.

Quick tips

  • Take it with or without food or at least 2 hours before bedtime. 
  • It may affect the blood sugar level. Take caution while taking this medicine if you are suffering from diabetes.
  • It may cause dizziness. Don't drive or do anything requiring concentration until you know how it affects you. 
  • Smoking may make Melocure 10mg Tablet less effective since it can increase the metabolism (breakdown) of it by the liver.
  • Avoid alcohol while taking this medicine, as it may decrease the activity of the drug.
  • Inform your doctor if you are taking seizure medicine, as Melocure 10mg Tablet may increase the frequency of seizures.
  • Do not take this medicine if you are allergic to Melocure 10mg Tablet, suffering from liver or kidney disease, or if you have an intolerance to some sugars.

Safety advice

Alcohol

Alcohol

UNSAFE
It is unsafe to consume alcohol with Melocure 10mg Tablet
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Melocure 10mg Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Melocure 10mg Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

UNSAFE
Melocure 10mg Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CONSULT YOUR DOCTOR
There is limited data available on the use of Melocure 10mg Tablet in patients with kidney disease. Please consult your doctor.
However, based on the limited information available, it is advised that Melocure 10mg Tablet should be used with caution in patients with kidney disease.
Liver

Liver

UNSAFE
Melocure 10mg Tablet is unsafe to use in patients with liver disease and should be avoided.

Interaction with drugs

Taking Melocure with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Fluvoxamine (Oral Route)

Do not consume Melatonin with Fluvoxamine. Fluvoxamine may raise blood levels of Melatonin.
Moderate

Thioridazine (Oral Route)

Talk to your doctor if you notice any unusual symptoms.Doctor may monitor your liver function. Melatonin may raise blood levels of Thioridazine.
Moderate

Alprazolam (Oral Route)

Do not drive or do anything requiring concentration or alertness until you know how the medicines affect you.
Moderate

Aripiprazole (Oral Route)

Talk to your doctor if you notice any unusual symptoms.Doctor may monitor your kidney function. Melatonin may decrease the metabolism of Aripiprazole.
Moderate

Pimozide (Oral Route)

Talk to your doctor if you notice any unusual symptoms. Melatonin may raise blood levels of the active form of Pimozide.

Frequently asked questions

The advantages of Melocure 10mg Tablet over other sleep agents include that this medicine does not make the patient develop tolerance (after some time of use of Melocure 10mg Tablet, it is no longer effective at the same dose). Unlike other similar hypnotic drugs, Melocure 10mg Tablet does not cause unwanted effects such as hangovers and physical dependence.
Yes, it may cause weight gain, but it is uncommon. Consult your doctor if you are concerned about putting on weight after taking Melocure 10mg Tablet.
Yes, you can take it every night, but consult your doctor for the duration of treatment. If you are taking it for jet lag, you will be advised to take a minimum effective dose for 5 days only. In other cases of insomnia, it can be taken for a little longer, for about 3 months.
Yes, Melocure 10mg Tablet may cause an increase in blood pressure, though it is an uncommon side effect. Therefore, if you are hypertensive, keep a watch on your blood pressure during treatment with Melocure 10mg Tablet. Consult your doctor as soon as you notice a change in blood pressure.
Usually, Melocure 10mg Tablet is taken once a day, before going to bed. Take it exactly as prescribed by your doctor. Melocure 10mg Tablet is a natural hormone produced by the body, which peaks at its highest levels at night.
Yes, Melocure 10mg Tablet can cause palpitations but only rarely. If you have any concerns regarding palpitations, consult your doctor.
No, unlike other medicines used to help people fall asleep, Melocure 10mg Tablet does not cause withdrawal symptoms.
Abnormal dreams are an uncommon side effect of Melocure 10mg Tablet. The reason for abnormal dreams is not known, but Melocure 10mg Tablet increases the duration of rapid eye movement (REM) sleep. This phase of sleep is usually associated with dreams. This increase in duration of REM could be the reason for abnormal dreams that occur while taking Melocure 10mg Tablet.
Yes, Melocure 10mg Tablet tablets can be used for treatment of jet-lag in adults. The biological day and night rhythm can be disturbed by travelling to countries lying in different time zones. This is known as jet-lag. The symptoms and their severity vary from person to person, but are generally worse and last longer the more time zones are crossed. Melocure 10mg Tablet tablets can help restore the normal day-and-night rhythm and reduce the symptoms.
Early morning awakening is a rare side effect of Melocure 10mg Tablet. If this is persistent and is bothering you, consult your doctor.

Fact Box

Chemical Class

3- alkylindoles

Habit Forming

No

Therapeutic Class

NEURO CNS

Action Class

Melatonin Receptor Agonists

References

  1. Dennehy CE, Tsourounis CT. Dietary Supplements & Herbal Medications. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 1123-25.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 857-58.
  3. Melatonin [EMC SmPC]. Barcarena, Portugal: Iberfar - Indústria Farmacêutica S.A; 2018. [Accessed 25 Mar. 2019] (online) Available from:
  4. Melatonin [EMC SmPC]. Dublin 2, Republic of Ireland: Flynn Pharma Ltd.; 2018. [Accessed 25 Mar 2019] (online) Available from:
  5. Central Drugs Standard Control Organisation (CDSCO). [Accessed 25 Mar. 2019] (online) Available from:
  6. Melatonin [Package Leaflet]. London, UK: Colonis Pharma Ltd.; 2021. [Accessed 20 Feb. 2024] (online) Available from:
  7. Melatonin [Summary of Product Characteristics]. Lund, Sweden: AGB-Pharma AB; 2021.
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Intas Pharmaceuticals Ltd
Address: Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Melocure 10mg Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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