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Manocol 400 Tablet DR

Mesalazine (400mg)
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Manocol 400 Tablet DR is an anti-inflammatory medicine used to treat a type of bowel disease known as ulcerative colitis. It helps to reduce symptoms such as diarrhea, bleeding and stomach pain by reducing inflammation in the bowel.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Lalit Kanodia, MBA, MD Pharmacology,
Last updated on 22 Sep 2025 | 02:40 PM (IST)
₹54.2 MRP ₹61.412% off 
 
 
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Manocol 400 Tablet DR image
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Product introduction

Manocol 400 Tablet DR may also be used to treat another type of bowel disease known as Crohn’s ileocolitis. It should be taken with food. The dose will depend on what you are being treated for but take it exactly as your doctor prescribes. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen.

The most common side effects of this medicine include nausea, diarrhea, stomach pain, headache, itching, flatulence, and vomiting. If these symptoms bother you, do not go away, or get worse, let your doctor know. There may be ways of reducing or preventing them. Some people may get a severe allergic reaction that needs urgent medical attention. Contact your doctor immediately if you notice symptoms like swelling of the face, tongue, throat, or lips, unusual bleeding, bruising, rash, fever, sore throat, or excessive tiredness. 

Before taking it, tell your doctor if you have any kidney or liver problems or a blockage in your stomach. Your age may also be a factor in deciding whether this medicine is suitable. Pregnant or breastfeeding women should also consult their doctor before taking this medicine. Let your doctor know about all other medications you are taking as some may affect, or be affected by this medicine.

Uses of Manocol Tablet DR

Benefits of Manocol Tablet DR

Ulcerative colitis
Ulcerative colitis is a form of inflammatory bowel disease (IBD) that causes inflammation and ulcers in the colon and rectum. Manocol 400 Tablet DR helps reduce the inflammation in the intestinal lining by targeting the disease locally. Reduction in inflammation promotes mucosal healing and causes symptoms like abdominal pain, diarrhea, and rectal bleeding to subside.
Crohn’s disease
Crohn’s disease is a type of inflammatory bowel disease that can affect any part of the digestive tract, causing symptoms like abdominal pain, diarrhea, and fatigue. Manocol 400 Tablet DR is used in mild to moderate cases to reduce inflammation and manage flare-ups. It can help prevent disease progression, reduce the need for steroids, and support intestinal health over time.

Side effects of Manocol Tablet DR

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Manocol
  • Flatulence
  • Headache
  • Vomiting
  • Diarrhea
  • Nausea
  • Abdominal pain
  • Rash
  • Stomach pain/epigastric pain

How to use Manocol Tablet DR

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Manocol 400 Tablet DR may be taken with or without food, but it is better to take it at a fixed time.

How Manocol Tablet DR works

Manocol 400 Tablet DR is an aminosalicylate. It works by suppressing the production of chemical messengers (prostaglandins) that cause inflammation (swelling) in the intestines. This reduces ulceration, bleeding and stomach pain, and prevents future flare-ups of the disease.

Quick tips

  • You have been prescribed Manocol 400 Tablet DR for treating and lowering the symptoms of mild inflammatory bowel disease such as ulcerative colitis.
  • Your doctor may monitor your kidney and liver functions before you start treatment with this medicine and regularly thereafter. Inform your doctor if you have severely decreased kidney or liver function.
  • Do not take Manocol 400 Tablet DR if you are allergic to aspirin or if you have blood disorders.
  • Do not stop taking the medication suddenly without talking to your doctor.
  • You have been prescribed Manocol 400 Tablet DR for treating and lowering the symptoms of mild inflammatory bowel disease such as ulcerative colitis.
  • Take it with food. Do not break, chew, or crush the tablets or granules. Swallow them whole with plenty of water.
  • Do not take antacids with Manocol 400 Tablet DR as it can make your inflammation worse.
  • Your doctor may monitor your kidney and liver functions before you start treatment with this medicine and regularly thereafter. Inform your doctor if you have severely decreased kidney or liver function.
  • Do not take Manocol 400 Tablet DR if you are allergic to aspirin or if you have blood disorders.

Safety advice

Alcohol

Alcohol

CAUTION
Caution is advised when consuming alcohol with Manocol 400 Tablet DR. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Manocol 400 Tablet DR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Manocol 400 Tablet DR is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
If you are taking Manocol 400 Tablet DR, monitor the baby for diarrhea.
Driving

Driving

SAFE
Manocol 400 Tablet DR does not usually affect your ability to drive.
Kidney

Kidney

CAUTION
Manocol 400 Tablet DR should be used with caution in patients with kidney disease. Dose adjustment of Manocol 400 Tablet DR may be needed. Please consult your doctor.
Use of Manocol 400 Tablet DR is not recommended in patients with severe kidney disease.
Liver

Liver

CAUTION
Manocol 400 Tablet DR should be used with caution in patients with liver disease. Dose adjustment of Manocol 400 Tablet DR may be needed. Please consult your doctor.

Interaction with drugs

Taking Manocol with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Moderate

Clozapine (Oral Route)

Your doctor may monitor your blood cell count and adjust the doses as per the observations.
Moderate

Azathioprine (Oral Route)

If concurrent use can not be avoided, your doctor may monitor your blood cell counts.
Moderate

Deferiprone (Oral Route)

If concurrent use can not be avoided, your doctor may monitor your blood cell counts.
Moderate

Mercaptopurine (Oral Route)

If concurrent use cannot be avoided, your doctor may monitor your blood cell counts.
Mild

Chlorpromazine (Oral Route)

Talk to your doctor if you notice any unusual symptoms.

Frequently asked questions

Continue to take Manocol 400 Tablet DR as advised by the doctor, even if you feel better at the beginning of your treatment. Do not stop taking Manocol 400 Tablet DR without consulting your doctor.
You should avoid alcohol if you have ulcerative colitis, as alcohol will irritate your stomach and intestine which will worsen your condition. Although alcohol does not interfere with the working of Manocol 400 Tablet DR, you should consult your doctor before taking alcohol.
Yes, Manocol 400 Tablet DR may cause joint pain. If the pain continues and bothers you inform your doctor.
Take Manocol 400 Tablet DR exactly as directed by your doctor.

Fact Box

Chemical Class

Aminosalicylic Acids Derivative

Habit Forming

No

Therapeutic Class

GASTRO INTESTINAL

Action Class

5-Aminosalicylic Acid (5-ASA)
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User feedback

Ulcerative colitis
100%
Average
100%
Abdominal pain
100%
With food
100%
Average
100%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Cmg Biotech Pvt Ltd
Address: 410, plot no. 4, dda building, swasthya vihar, delhi, 110092

Vendor Details

Country of origin: India
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