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Macgest SR 300 Tablet is a natural female sex hormone, progesterone. It is used to treat menstrual and pregnancy-related issues that are caused by hormonal imbalance.

Written By Dr. Lipika Khurana, PGDHHM, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 13 Mar 2026 | 01:39 PM (IST)
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The content is shown in English
Macgest SR 300 Tablet image
Macgest SR 300 Tablet image
Macgest SR 300 Tablet image
Macgest SR 300 Tablet image
Macgest SR 300 Tablet image
Macgest SR 300 Tablet image
Macgest SR 300 Tablet image

Product introduction

Macgest SR 300 Tablet is also prescribed, along with estrogen, as a part of hormonal replacement therapy for preventing endometrial hyperplasia (thickening of the lining of the uterus). It should be taken with food. It should be taken at the same time each day to get the most benefit. You should continue taking it for as long as your doctor has told you to, even if you feel well.


The most common side effects include headache, breast pain, irregular vaginal bleeding or spotting, stomach or abdominal cramps, bloating, nausea and vomiting, hair loss, edema, and vaginal yeast infection. Side effects are more common during the first few weeks and usually lessen as your body gets used to the medicine. You may also experience bleeding or spotting between your periods; consult with your doctor if it happens frequently.


Before taking this medicine, inform your doctor if you have, or have had, breast cancer, unusual bleeding in the vagina, or liver disease. You will probably have several tests both before and during treatment to check your womb. Also, tell your doctor what other medicines you are taking, as some may affect, or be affected by, this medicine. In general, it is advisable to avoid alcohol and smoking.

Benefits of Macgest Tablet SR

Treatment of Female infertility
Macgest SR 300 Tablet contains progesterone, a female hormone that is important in the regulation of ovulation and menstruation. It is used to cause menstrual periods in women who have not reached menopause but are not having periods due to a lack of natural progesterone in the body. This medicine helps to prepare the uterus for pregnancy by causing the uterus lining (endometrium) to thicken. This increases the chance of a successful pregnancy. You should use the medicine as prescribed for it to be effective. You may be asked to continue with this treatment for a period after becoming pregnant.
Hormone replacement therapy
Hormone placement therapy (HRT) is a treatment to relieve symptoms of menopause such as hot flushes, night sweats, mood swings, vaginal dryness, and reduced sex drive. Since menopause can last for several years, this treatment can make a big improvement to your daily life and mood. Progesterone is one of two important hormones (the other being is estrogen) used in this treatment. However, it may not treat all your symptoms, consult with your doctor. You should use this medicine as it is prescribed, and for as long as it is prescribed by your doctor.

Side effects of Macgest Tablet SR

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Macgest
  • Vomiting
  • Vaginal yeast infection
  • Abdominal pain
  • Nausea
  • Abnormal vaginal bleeding
  • Edema (swelling)
  • Headache
  • Breast pain
  • Bloating

How to use Macgest Tablet SR

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Macgest SR 300 Tablet should be taken with or after food.

How Macgest Tablet SR works

Macgest SR 300 Tablet is a progesterone (female hormone). It helps to establish and maintain pregnancy. It also prevents the increase in thickness of the endometrium (lining of the uterus) caused by estrogen.

Quick tips

  • Macgest SR 300 Tablet may also be used in the treatment of problems related to the menstrual period, such as amenorrhea (absence of periods).
  • It also helps in the maintenance of pregnancy in women who are at higher risk of miscarriage.
  • It should be taken with food.
  • It may cause sleepiness or drowsiness. If this happens to you, do not drive or use machinery.

Safety advice

Alcohol

Alcohol

CAUTION
Alcohol should be used with caution while taking Macgest SR 300 Tablet.
Pregnancy

Pregnancy

SAFE IF PRESCRIBED
Macgest SR 300 Tablet is safe to use during pregnancy. Most studies have shown low or no risk to the developing baby.
Breast feeding

Breast feeding

CAUTION
Macgest SR 300 Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.
Driving

Driving

UNSAFE
Macgest SR 300 Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CONSULT YOUR DOCTOR
There is limited data available on the use of Macgest SR 300 Tablet in patients with kidney disease. Please consult your doctor.
Liver

Liver

CAUTION
Macgest SR 300 Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Macgest with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Darunavir (Oral Route)

It is recommended to use barrier methods (like condoms), IUDs, or a depot for contraception. Your doctor may monitor your treatment closely and adjust the doses as per the observations. Use barrier methods (like condoms) for contraception to reduce the risk of HIV infection.
Severe

Mycophenolate mofetil (Oral Route)

Effective contraception must be used before, during, and for at least 6 weeks after stopping Mycophenolate mofetil. It is recommended to consult your doctor. Mycophenolate mofetil may reduce the efficacy of Progesterone (Natural Micronized).
Severe

Perampanel (Oral Route)

It is recommended to use barrier methods (like condoms), IUDs, or a depot for contraception. Your doctor may monitor your treatment closely and adjust the doses as per the observations. Use barrier methods (like condoms) for contraception to reduce the risk of HIV infection. Perampanel may reduce the efficacy of Progesterone (Natural Micronized).
Severe

Saquinavir (Oral Route)

It is recommended to use barrier methods (like condoms), IUDs, or a depot for contraception. Your doctor may monitor your treatment closely and adjust the doses as per the observations. Use barrier methods (like condoms) for contraception to reduce the risk of HIV infection.
Severe

Tamoxifen (Oral Route)

Do not consume Tamoxifen with Progesterone (Natural Micronized) if you have or had breast cancer. If essential, consult your doctor.

Frequently asked questions

Macgest SR 300 Tablet is a type of progesterone hormone which is extracted from plants, but its properties match those of human progesterone. This medicine undergoes a process called micronization, where the size of the natural progesterone is reduced. The small size of the progesterone particles enhances its dissolution and absorption. This provides better availability of Macgest SR 300 Tablet in the body and decreases its side effects.
Macgest SR 300 Tablet is used to treat various disorders. It is given to women with secondary amenorrhea (no menstruation for 3 months in women who have had their menses before). It is used to support pregnancy, prevent premature labor, and treat bleeding disorders that may occur before menopause. It may be used as a part of fertility treatment and may be given as hormone replacement therapy after menopause. It is also given to relieve symptoms of premenstrual syndrome and painful bleeding, like in dysfunctional uterine bleeding.
Yes, Macgest SR 300 Tablet can be taken every day. It is usually prescribed to be taken once daily in the evening or at bedtime. The usual duration of prescription may vary from 10-12 days a month to 25 days a month. However, the number of days for which you will need to take this medicine in each cycle will be suggested by your doctor, depending on your health condition.
Yes, taking Macgest SR 300 Tablet may cause weight gain. The weight gain may be due to water retention and may not be a serious sign. However, contact your doctor in case your weight gain is worrying you. The risk of weight gain is generally less if Macgest SR 300 Tablet is taken with estrogen as a combined pill. But, do not start any hormonal therapy without consulting your doctor.
Progesterone is a very crucial hormone in fertility. It is the hormone secreted by the ovaries that helps prepare the uterus for pregnancy and maintain it. Macgest SR 300 Tablet (natural micronized form of progesterone) is given as a medicine in cases of infertility to support the uterus in preparing itself for the pregnancy and to prevent abortions in some cases. It is also used to prevent premature labor.

Fact Box

Chemical Class

Gluco/mineralocorticoids, progestogin derivative

Habit Forming

No

Therapeutic Class

GYNAECOLOGICAL

Action Class

Natural Progesterone
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User feedback

Once A Day
87%
Twice A Day
13%
Female infertility
42%
Others
32%
Hormone replacement therapy
26%
Poor
44%
Excellent
44%
Average
11%
Headache
40%
Abdominal pain
20%
Fatigue
20%
Sleepiness
20%
With food
80%
With or without food
20%
Expensive
58%
Average
25%
Not Expensive
17%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Macleods Pharmaceuticals Pvt Ltd
Address: Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Macgest SR 300 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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