Macbutin Tablet is an antibiotic, used in the treatment of tuberculosis with HIV (human immunodeficiency virus) infection. It helps to fight germs (bacteria) called mycobacteria, which cannot be destroyed by other antibiotics in people who have a weaker immunity.

Macbutin Tablet may be used alone or in combination with other medicines to help prevent serious infections caused by microorganisms like mycobacterium avium complex (MAC). It should be taken in the dose and duration as advised by the doctor. This medicine should be taken on an empty stomach. It is better to take it at the same time each day to get the most benefit and you should keep on taking this medicine for as long as you are prescribed. Stopping it early may make the infection to come back and harder to treat.

Some people may develop side effects like decreased white blood cells, anemia, rash, nausea, and fever. These side effects are usually temporary and go away during treatment as your body adjusts to the medicine. Consult your doctor if these side effects bother you or do not go away.

Before starting treatment with this medicine, you should tell your doctor if you are pregnant, breastfeeding, or suffering from any liver, kidney, or heart problems or if you are allergic to any medicine. You may be regularly monitored with blood tests and chest x-rays to check that you do not have active tuberculosis or any other mycobacterial disease. Your doctor may advise for regular eye examination and liver function tests while using it.

Uses of Macbutin Tablet

Tuberculosis with HIV infection

Benefits of Macbutin Tablet

In Tuberculosis with HIV infection

Macbutin Tablet helps treat Mycobacterium avium complex disease (MAC; a bacterial infection that may cause serious symptoms) in patients with human immunodeficiency virus (HIV) infection. It kills as well as stops the growth of infection causing bacteria and helps in treating the infection. Take it in the dose and duration advised by the doctor. Your symptoms may improve before the infection is completely cured. Do not stop taking it without consulting your doctor as doing so may cause the infection to return or worsen. Follow your doctor’s instructions carefully to get maximum benefit.

Side effects of Macbutin Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Macbutin

Nausea
Rash
Fever
Anemia (low number of red blood cells)
Decreased white blood cell count

How to use Macbutin Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Macbutin Tablet is to be taken on an empty stomach.
Avoid Macbutin Tablet with acidic food and beverages such as sugar, certain dairy products, fish, processed foods, fresh meats and processed meats,sodas and other sweetened beverages.

How Macbutin Tablet works

Macbutin Tablet works by inhibiting an enzyme DNA-dependent RNA polymerase in bacteria, leading to the suppression of RNA synthesis that is required for survival and this leads to cell death of infection-causing bacteria. This helps treat Mycobacterium avium complex disease (tuberculosis) in patients with human immunodeficiency virus (HIV) infection.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Macbutin Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Macbutin Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CAUTION

Macbutin Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.

Driving

CONSULT YOUR DOCTOR

It is not known whether Macbutin Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

CAUTION

Macbutin Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Macbutin Tablet should be used with caution in patients with severe liver disease. Dose adjustment may be needed.

What if you forget to take Macbutin Tablet?

If you miss a dose of Macbutin Tablet, contact your doctor as soon as possible. They will advise you on how to proceed, which may include rescheduling the missed dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

No substitutes found for this medicine

Quick tips

Macbutin Tablet is used to treat tuberculosis in patients with HIV.
Seek immediate medical attention if you develop sudden wheeziness, difficulty in breathing, pain in the chest, swelling of eyelids, face, or lips, rash or itching.
Taking Macbutin Tablet may change the color of your urine to red/orange. You may also experience coloring of the skin and other body fluids and also of soft contact lenses.
You may be regularly monitored with blood tests and chest X-rays to check that you do not have active tuberculosis or any other mycobacterial disease.
You may also undergo regular eye examinations while using Macbutin Tablet.
Use non-hormonal birth control techniques (condom, diaphragm with spermicide) to prevent pregnancy, as Macbutin Tablet can make birth control pills less effective.

Fact Box

Chemical Class

Macrolactams

Habit Forming

Therapeutic Class

ANTI INFECTIVES

Action Class

RNA polymerase inhibitors- Rifamycins

Interaction with drugs

Taking Macbutin with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Tenofovir Alafenamide (Oral Route) Severe

Do not consume Tenofovir Alafenamide with Rifabutin. Rifabutin may reduce blood levels of Tenofovir Alafenamide.

Sorafenib (Oral Route) Severe

Rifabutin may reduce blood levels of Sorafenib. Rifabutin may reduce blood levels of Sorafenib. Avoid concomitant use.

Ulipristal acetate (Oral Route) Severe

Do not consume Ulipristal acetate with Rifabutin. If Ulipristal acetate is essential, ensure a gap of At least 4 weeks after discontinuing Rifabutin. Please consult your doctor. R... More

Allylestrenol (Oral Route) Severe

Use other methods of contraception (IUDs, depot or barrier methods) both during and for 28 days following the discontinuation of Rifabutin. Rifabutin may reduce the efficacy of All... More

Axitinib (Oral Route) Severe

Rifabutin may reduce blood levels of Axitinib. Rifabutin may reduce blood levels of Axitinib. Concurrent use should be avoided.

View all drug interactions

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Related lab tests

HIV 1 - Quantitative (Viral Load)

HIV 1 And 2 Antibody - ELISA

Mycobacterium Tuberculosis DNA PCR - Qualitative

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Gumbo T. Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1550-554.
Chambers HF, Deck DH. Antimycobacterial Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 829.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1212-13.
Rifabutin. Sandwich, Kent: Pfizer Limited; 2003 [revised Dec. 2015]. [Accessed 25 Jan. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 01 Apr. 2019] (online) Available from: