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Lizen 450mg Tablet ER

Lithium carbonate (450mg)
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Lizen 450mg Tablet ER is used in the treatment of bipolar disorder and mania in adults. It is sometimes used to treat other behavioral disorders as well. It reduces the frequency of manic episodes and decreases the intensity of those episodes that might occur.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 25 Nov 2025 | 03:05 PM (IST)
₹66.2 MRP ₹7512% off 
 
 
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Lizen 450mg Tablet ER image
Lizen 450mg Tablet ER image

Product introduction

Lizen 450mg Tablet ER should be taken with food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Do not skip any doses and finish the full course of treatment even if you feel better. If you have missed a dose, take it as soon as you remember it. You should continue to take this medicine for as long as the doctor advises and do not stop taking it suddenly as it may result in harmful effects.

Side effects associated with the use of this medicine include tremors, slurred speech, uncoordinated body movements, nausea, Vomiting, acne, increased white blood cell count, and memory impairment. It may also cause hair loss, enlarged thyroid gland, skin rash, and increased thirst. This medicine may also cause weight gain and to control it, you should have a balanced diet and exercise regularly. If you have been taking this medicine for a long time then regular monitoring of thyroid and kidney function may be required.

Uses of Lizen Tablet ER

Benefits of Lizen Tablet ER

Mania
Lizen 450mg Tablet ER is used to manage manic episodes by helping reduce extreme mood swings, agitation, and overactivity, allowing individuals to regain emotional balance.
Bipolar disorder
In bipolar disorder, Lizen 450mg Tablet ER helps stabilize mood over time, reducing the frequency and intensity of depressive episodes, and supporting long-term mental health management.

Side effects of Lizen Tablet ER

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Lizen
  • Dryness in mouth
  • Headache
  • Nausea
  • Weight gain
  • Hand tremors
  • Confusion
  • Decreased memory
  • Feeling thirsty
  • Muscle weakness
  • ECG changes
  • Vertigo
  • Vomiting
  • Polyuria
  • Increased white blood cell count

How to use Lizen Tablet ER

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Lizen 450mg Tablet ER should be taken with or after food.

How Lizen Tablet ER works

Lizen 450mg Tablet ER works by suppressing the abnormal and excessive activity of the nerve cells in the brain.

Quick tips

  • Lizen 450mg Tablet ER is one of the most effective long-term treatment for bipolar disorder.
  • It may also be used for the treatment of mania.
  • Your lithium blood levels, thyroid function, and kidney function may be monitored as long as you take this medicine.
  • It may cause diarrhea and dehydration. Drink plenty of water and and use normal amounts of salt. Inform your doctor if you start or stop a low-salt diet.
  • Monitor your weight during treatment as Lizen 450mg Tablet ER can cause weight gain.
  • Do not drive or do anything that requires mental focus until you know how it affects you.
  • Inform your doctor if you have persistent stomach upset, problems with your speech, or extreme drowsiness. Your dose may need to be adjusted.
  • Do not take Lizen 450mg Tablet ER if you are pregnant or breastfeeding.
  • Do not stop taking the medication suddenly without talking to your doctor.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Lizen 450mg Tablet ER. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Lizen 450mg Tablet ER is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Lizen 450mg Tablet ER during breastfeeding is not available. Please consult your doctor.
Driving

Driving

UNSAFE
Lizen 450mg Tablet ER may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Lizen 450mg Tablet ER should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Lizen 450mg Tablet ER should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Lizen with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Life-threatening

Domperidone (Oral Route)

Do not consume Domperidone with Lithium carbonate.
Severe

Thioridazine (Oral Route)

If concurrent use is essential, watch out for symptoms such as double vision, weakness, dizziness, impaired coordination, or confusion and consult your doctor if you experience them. Factors such as old age, chronic heart issues, or low potassium levels may more frequently cause disturbance in heart rhythm, and your doctor may consider ECG monitoring in their presence. Your doctor may discontinue the medicines if required.
Severe

Amiodarone (Oral Route)

Factors such as old age, chronic heart issues, or low potassium levels may more frequently cause disturbance in heart rhythm, and your doctor may consider ECG monitoring in their presence.
Severe

Haloperidol (Oral Route)

Careful consideration is advised when taking Haloperidol with Lithium carbonate. If concurrent use is essential, watch out for symptoms such as impaired movements, dizziness or drowsiness and consult your doctor if you experience them. Factors such as old age, chronic heart issues, or low potassium levels may more frequently cause disturbance in heart rhythm, and your doctor may consider ECG monitoring in their presence.
Severe

Hydroxyzine (Oral Route)

Do not consume Hydroxyzine with Lithium carbonate.

Frequently asked questions

It takes some time before you see improvement in your symptoms after taking Lizen 450mg Tablet ER. Though it varies from person to person, it may take 1-3 weeks or longer for you to see the full benefits of Lizen 450mg Tablet ER. Do not stop taking Lizen 450mg Tablet ER if you feel you are not improving. Instead, discuss it with your doctor.
Yes, Lizen 450mg Tablet ER can cause nervous system disorders like sleepiness and dizziness and feeling confused. It can also cause rapid eye movements, blurred vision, or blind spots in your eyesight. If you experience any of these symptoms, consult your doctor. In addition, avoid driving or operating heavy machinery as it can be hazardous for you.
Yes, Lizen 450mg Tablet ER may cause kidney problems. Lizen 450mg Tablet ER is not prescribed in patients who already have severe kidney impairment. The kidney problems may not be reversible and the symptoms include swollen ankles, passing a lot of urine and feeling thirsty. Before starting treatment with Lizen 450mg Tablet ER, your doctor will get blood tests done to see if your kidney function is normal. During Lizen 450mg Tablet ER therapy, any gradual or sudden changes in renal function, even within the normal range, may indicate the need for re-evaluation of treatment.
Lizen 450mg Tablet ER can cause both weight gain or weight loss. You should keep a check on your weight during Lizen 450mg Tablet ER therapy. If you feel you are gaining or losing too much weight, consult your doctor who will assess whether the change in weight is due to Lizen 450mg Tablet ER or some other reason.
Lizen 450mg Tablet ER therapy should only be started if adequate facilities for assessing Lizen 450mg Tablet ER levels are available. This is because Lizen 450mg Tablet ER toxicity is related to increased levels of Lizen 450mg Tablet ER in blood. Lizen 450mg Tablet ER toxicity can even occur at dose which is effective for treatment. Therefore, your doctor may closely monitor your Lizen 450mg Tablet ER levels weekly until stabilization is achieved, then weekly for one month and then at monthly intervals thereafter.
Take Lizen 450mg Tablet ER exactly as prescribed by your doctor. Check with your doctor if you are not sure. It is meant for oral administration and can be taken with or without food. However, if you start following a certain type of diet, talk to your doctor first. Any drastic changes in the amount of water you drink or amount of sodium (salt) in your diet may require more frequent monitoring of Lizen 450mg Tablet ER levels.
You should inform your doctor about the medicines you are taking before starting Lizen 450mg Tablet ER since many medicines interfere with the working of Lizen 450mg Tablet ER. Some medicines decrease the levels of Lizen 450mg Tablet ER in blood which means that it will not work well. These include theophylline (for asthma), caffeine, anything containing sodium bicarbonate, or a special group of diuretics (water tablets) called carbonic anhydrase inhibitors and urea used to treat skin conditions.
It takes some time before you see improvement in your symptoms after taking Lizen 450mg Tablet ER. Though it varies from person to person, it may take 1-3 weeks or longer for you to see the full benefits of Lizen 450mg Tablet ER. Do not stop taking Lizen 450mg Tablet ER if you feel you are not improving. Instead, discuss it with your doctor.
Yes, Lizen 450mg Tablet ER can cause nervous system disorders like sleepiness and dizziness and feeling confused. It can also cause rapid eye movements, blurred vision, or blind spots in your eyesight. If you experience any of these symptoms, consult your doctor. In addition, avoid driving or operating heavy machinery as it can be hazardous for you.
Yes, Lizen 450mg Tablet ER may cause kidney problems. Lizen 450mg Tablet ER is not prescribed in patients who already have severe kidney impairment. The kidney problems may not be reversible and the symptoms include swollen ankles, passing a lot of urine and feeling thirsty. Before starting treatment with Lizen 450mg Tablet ER, your doctor will get blood tests done to see if your kidney function is normal. During Lizen 450mg Tablet ER therapy, any gradual or sudden changes in renal function, even within the normal range, may indicate the need for re-evaluation of treatment.
Lizen 450mg Tablet ER can cause both weight gain or weight loss. You should keep a check on your weight during Lizen 450mg Tablet ER therapy. If you feel you are gaining or losing too much weight, consult your doctor who will assess whether the change in weight is due to Lizen 450mg Tablet ER or some other reason.
Lizen 450mg Tablet ER therapy should only be started if adequate facilities for assessing Lizen 450mg Tablet ER levels are available. This is because Lizen 450mg Tablet ER toxicity is related to increased levels of Lizen 450mg Tablet ER in blood. Lizen 450mg Tablet ER toxicity can even occur at dose which is effective for treatment. Therefore, your doctor may closely monitor your Lizen 450mg Tablet ER levels weekly until stabilization is achieved, then weekly for one month and then at monthly intervals thereafter.
Take Lizen 450mg Tablet ER exactly as prescribed by your doctor. Check with your doctor if you are not sure. It is meant for oral administration and can be taken with or without food. However, if you start following a certain type of diet, talk to your doctor first. Any drastic changes in the amount of water you drink or amount of sodium (salt) in your diet may require more frequent monitoring of Lizen 450mg Tablet ER levels.
You should inform your doctor about the medicines you are taking before starting Lizen 450mg Tablet ER since many medicines interfere with the working of Lizen 450mg Tablet ER. Some medicines decrease the levels of Lizen 450mg Tablet ER in blood which means that it will not work well. These include theophylline (for asthma), caffeine, anything containing sodium bicarbonate, or a special group of diuretics (water tablets) called carbonic anhydrase inhibitors and urea used to treat skin conditions.

Fact Box

Chemical Class

Organic carbonic acids

Habit Forming

No

Therapeutic Class

NEURO CNS

Action Class

Mood Stabilizers

References

  1. Stahl SM, editor. Lithium. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 349-54.
  2. Meltzer H. Antipsychotic Agents & Lithium. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 502-504.
  3. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Lithium. [Updated 2020 Jan 20]. [Accessed 20 Feb. 2020] (online) Available from:
  4. Central Drugs Standard Control Organisation (CDSCO). [Accessed 25 Mar. 2019] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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Address: Theo Pharma Pvt Ltd, 401, Sachet-3, Mirambica School Road, Naranpura, Naranpura

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Country of origin: India
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