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Lithon 450mg Tablet SR

Written By Dr. Sakshi Jain, MS, BDS
Reviewed By Dr. Mekhala Chandra, MD, MBBS
Last updated on 25 Nov 2025 | 12:35 AM (IST)
Lithon 450mg Tablet SR is used in the treatment of bipolar disorder and mania in adults. It is sometimes used to treat other behavioral disorders as well. It reduces the frequency of manic episodes and decreases the intensity of those episodes that might occur.
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General Information

Contains

Lithium carbonate (450mg)

Marketer

RKG Pharma

Storage

Store below 30°C
The content is shown in English
Lithon 450mg Tablet SR image
Lithon 450mg Tablet SR image

Product introduction

Lithon 450mg Tablet SR should be taken with food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Do not skip any doses and finish the full course of treatment even if you feel better. If you have missed a dose, take it as soon as you remember it. You should continue to take this medicine for as long as the doctor advises and do not stop taking it suddenly as it may result in harmful effects.

Side effects associated with the use of this medicine include tremors, slurred speech, uncoordinated body movements, nausea, Vomiting, acne, increased white blood cell count, and memory impairment. It may also cause hair loss, enlarged thyroid gland, skin rash, and increased thirst. This medicine may also cause weight gain and to control it, you should have a balanced diet and exercise regularly. If you have been taking this medicine for a long time then regular monitoring of thyroid and kidney function may be required.

Uses of Lithon Tablet SR

Benefits of Lithon Tablet SR

Mania
Lithon 450mg Tablet SR is used to manage manic episodes by helping reduce extreme mood swings, agitation, and overactivity, allowing individuals to regain emotional balance.
Bipolar disorder
In bipolar disorder, Lithon 450mg Tablet SR helps stabilize mood over time, reducing the frequency and intensity of depressive episodes, and supporting long-term mental health management.

Side effects of Lithon Tablet SR

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Lithon
  • Dryness in mouth
  • Headache
  • Nausea
  • Weight gain
  • Hand tremors
  • Confusion
  • Decreased memory
  • Feeling thirsty
  • Muscle weakness
  • ECG changes
  • Vertigo
  • Vomiting
  • Polyuria
  • Increased white blood cell count

How to use Lithon Tablet SR

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Lithon 450mg Tablet SR should be taken with or after food.

How Lithon Tablet SR works

Lithon 450mg Tablet SR works by suppressing the abnormal and excessive activity of the nerve cells in the brain.

All substitutes for Lithon 450mg Tablet SR

For information purposes only. Consult a doctor before taking any medicine.

Manilith 450 SR Tablet

by Psychocare Health Pvt Ltd
₹3.89/tablet sr
56% costlier
<h3 class=bodySemiBold>Manilith 450 SR Tablet</h3>

Lisalt 450mg Tablet SR

by A N Pharmacia
₹4.78/tablet sr
91% costlier
<h3 class=bodySemiBold>Lisalt 450mg Tablet SR</h3>

Quick tips

  • Lithon 450mg Tablet SR is one of the most effective long-term treatment for bipolar disorder.
  • It may also be used for the treatment of mania.
  • Your lithium blood levels, thyroid function, and kidney function may be monitored as long as you take this medicine.
  • It may cause diarrhea and dehydration. Drink plenty of water and and use normal amounts of salt. Inform your doctor if you start or stop a low-salt diet.
  • Monitor your weight during treatment as Lithon 450mg Tablet SR can cause weight gain.
  • Do not drive or do anything that requires mental focus until you know how it affects you.
  • Inform your doctor if you have persistent stomach upset, problems with your speech, or extreme drowsiness. Your dose may need to be adjusted.
  • Do not take Lithon 450mg Tablet SR if you are pregnant or breastfeeding.
  • Do not stop taking the medication suddenly without talking to your doctor.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Lithon 450mg Tablet SR. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Lithon 450mg Tablet SR is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Lithon 450mg Tablet SR during breastfeeding is not available. Please consult your doctor.
Driving

Driving

UNSAFE
Lithon 450mg Tablet SR may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Lithon 450mg Tablet SR should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Lithon 450mg Tablet SR should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Lithon with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Life-threatening

Domperidone (Oral Route)

Do not consume Domperidone with Lithium carbonate.
Severe

Thioridazine (Oral Route)

If concurrent use is essential, watch out for symptoms such as double vision, weakness, dizziness, impaired coordination, or confusion and consult your doctor if you experience them. Factors such as old age, chronic heart issues, or low potassium levels may more frequently cause disturbance in heart rhythm, and your doctor may consider ECG monitoring in their presence. Your doctor may discontinue the medicines if required.
Severe

Amiodarone (Oral Route)

Factors such as old age, chronic heart issues, or low potassium levels may more frequently cause disturbance in heart rhythm, and your doctor may consider ECG monitoring in their presence.
Severe

Haloperidol (Oral Route)

Careful consideration is advised when taking Haloperidol with Lithium carbonate. If concurrent use is essential, watch out for symptoms such as impaired movements, dizziness or drowsiness and consult your doctor if you experience them. Factors such as old age, chronic heart issues, or low potassium levels may more frequently cause disturbance in heart rhythm, and your doctor may consider ECG monitoring in their presence.
Severe

Hydroxyzine (Oral Route)

Do not consume Hydroxyzine with Lithium carbonate.

Frequently asked questions

It takes some time before you see improvement in your symptoms after taking Lithon 450mg Tablet SR. Though it varies from person to person, it may take 1-3 weeks or longer for you to see the full benefits of Lithon 450mg Tablet SR. Do not stop taking Lithon 450mg Tablet SR if you feel you are not improving. Instead, discuss it with your doctor.
Yes, Lithon 450mg Tablet SR can cause nervous system disorders like sleepiness and dizziness and feeling confused. It can also cause rapid eye movements, blurred vision, or blind spots in your eyesight. If you experience any of these symptoms, consult your doctor. In addition, avoid driving or operating heavy machinery as it can be hazardous for you.
Yes, Lithon 450mg Tablet SR may cause kidney problems. Lithon 450mg Tablet SR is not prescribed in patients who already have severe kidney impairment. The kidney problems may not be reversible and the symptoms include swollen ankles, passing a lot of urine and feeling thirsty. Before starting treatment with Lithon 450mg Tablet SR, your doctor will get blood tests done to see if your kidney function is normal. During Lithon 450mg Tablet SR therapy, any gradual or sudden changes in renal function, even within the normal range, may indicate the need for re-evaluation of treatment.
Lithon 450mg Tablet SR can cause both weight gain or weight loss. You should keep a check on your weight during Lithon 450mg Tablet SR therapy. If you feel you are gaining or losing too much weight, consult your doctor who will assess whether the change in weight is due to Lithon 450mg Tablet SR or some other reason.
Lithon 450mg Tablet SR therapy should only be started if adequate facilities for assessing Lithon 450mg Tablet SR levels are available. This is because Lithon 450mg Tablet SR toxicity is related to increased levels of Lithon 450mg Tablet SR in blood. Lithon 450mg Tablet SR toxicity can even occur at dose which is effective for treatment. Therefore, your doctor may closely monitor your Lithon 450mg Tablet SR levels weekly until stabilization is achieved, then weekly for one month and then at monthly intervals thereafter.
Take Lithon 450mg Tablet SR exactly as prescribed by your doctor. Check with your doctor if you are not sure. It is meant for oral administration and can be taken with or without food. However, if you start following a certain type of diet, talk to your doctor first. Any drastic changes in the amount of water you drink or amount of sodium (salt) in your diet may require more frequent monitoring of Lithon 450mg Tablet SR levels.
You should inform your doctor about the medicines you are taking before starting Lithon 450mg Tablet SR since many medicines interfere with the working of Lithon 450mg Tablet SR. Some medicines decrease the levels of Lithon 450mg Tablet SR in blood which means that it will not work well. These include theophylline (for asthma), caffeine, anything containing sodium bicarbonate, or a special group of diuretics (water tablets) called carbonic anhydrase inhibitors and urea used to treat skin conditions.
It takes some time before you see improvement in your symptoms after taking Lithon 450mg Tablet SR. Though it varies from person to person, it may take 1-3 weeks or longer for you to see the full benefits of Lithon 450mg Tablet SR. Do not stop taking Lithon 450mg Tablet SR if you feel you are not improving. Instead, discuss it with your doctor.
Yes, Lithon 450mg Tablet SR can cause nervous system disorders like sleepiness and dizziness and feeling confused. It can also cause rapid eye movements, blurred vision, or blind spots in your eyesight. If you experience any of these symptoms, consult your doctor. In addition, avoid driving or operating heavy machinery as it can be hazardous for you.
Yes, Lithon 450mg Tablet SR may cause kidney problems. Lithon 450mg Tablet SR is not prescribed in patients who already have severe kidney impairment. The kidney problems may not be reversible and the symptoms include swollen ankles, passing a lot of urine and feeling thirsty. Before starting treatment with Lithon 450mg Tablet SR, your doctor will get blood tests done to see if your kidney function is normal. During Lithon 450mg Tablet SR therapy, any gradual or sudden changes in renal function, even within the normal range, may indicate the need for re-evaluation of treatment.
Lithon 450mg Tablet SR can cause both weight gain or weight loss. You should keep a check on your weight during Lithon 450mg Tablet SR therapy. If you feel you are gaining or losing too much weight, consult your doctor who will assess whether the change in weight is due to Lithon 450mg Tablet SR or some other reason.
Lithon 450mg Tablet SR therapy should only be started if adequate facilities for assessing Lithon 450mg Tablet SR levels are available. This is because Lithon 450mg Tablet SR toxicity is related to increased levels of Lithon 450mg Tablet SR in blood. Lithon 450mg Tablet SR toxicity can even occur at dose which is effective for treatment. Therefore, your doctor may closely monitor your Lithon 450mg Tablet SR levels weekly until stabilization is achieved, then weekly for one month and then at monthly intervals thereafter.
Take Lithon 450mg Tablet SR exactly as prescribed by your doctor. Check with your doctor if you are not sure. It is meant for oral administration and can be taken with or without food. However, if you start following a certain type of diet, talk to your doctor first. Any drastic changes in the amount of water you drink or amount of sodium (salt) in your diet may require more frequent monitoring of Lithon 450mg Tablet SR levels.
You should inform your doctor about the medicines you are taking before starting Lithon 450mg Tablet SR since many medicines interfere with the working of Lithon 450mg Tablet SR. Some medicines decrease the levels of Lithon 450mg Tablet SR in blood which means that it will not work well. These include theophylline (for asthma), caffeine, anything containing sodium bicarbonate, or a special group of diuretics (water tablets) called carbonic anhydrase inhibitors and urea used to treat skin conditions.

Fact Box

Chemical Class

Organic carbonic acids

Habit Forming

No

Therapeutic Class

NEURO CNS

Action Class

Mood Stabilizers

References

  1. Stahl SM, editor. Lithium. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 349-54.
  2. Meltzer H. Antipsychotic Agents & Lithium. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 502-504.
  3. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Lithium. [Updated 2020 Jan 20]. [Accessed 20 Feb. 2020] (online) Available from:
  4. Central Drugs Standard Control Organisation (CDSCO). [Accessed 25 Mar. 2019] (online) Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: RKG Pharma
Address: 12th Milestone, Mathura Road, Faridabad – 121 003

Vendor Details

Country of origin: India

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