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Kuffdryl 25mg Tablet

Diphenhydramine (25mg)
Genuine
Authenticity Assured
Prescription
required
Kuffdryl 25mg Tablet is an antihistaminic medicine. It is used to treat symptoms of nasal allergy such as sneezing, runny nose, itching, and watery eyes. It may also be used to treat insomnia and motion sickness.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 19 Jun 2026 | 05:44 PM (IST)
₹22.2 MRP ₹27.7520% off 
 
 
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General Information

The content is shown in English
Kuffdryl 25mg Tablet image
Kuffdryl 25mg Tablet image

Product introduction

Kuffdryl 25mg Tablet is best taken before a meal or at bedtime. Take it exactly as prescribed by your doctor. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. Take it for as long as it is prescribed for you. In case, you have missed any doses, take the next dose as soon as you remember it. However, you should never take a double dose.

Dizziness and drowsiness are the most common side effect of this medicine. Avoid driving or attention-seeking activities while on treatment with this medicine. In some cases, it may cause also dryness of mouth. To prevent dry mouth, drink more water and maintain good oral hygiene.

Before taking this medicine, let your doctor know if you have glaucoma or have any gastro-related issues or have asthma. Inform your doctor if you are pregnant, or breastfeeding. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Generally, it is advised to avoid alcohol while on treatment.

Uses of Kuffdryl Tablet

Benefits of Kuffdryl Tablet

Treatment of Nasal allergy symptoms
Allergic reactions often involve the release of histamine, a chemical that leads to itching, redness, and inflammation on the skin. When applied, Kuffdryl 25mg Tablet blocks histamine receptors on the skin cells. By reducing histamine's effects, the medicine helps alleviate the uncomfortable symptoms associated with allergic skin conditions, providing relief from itching and reducing inflammation.

Side effects of Kuffdryl Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Kuffdryl
  • Sedation
  • Drowsiness
  • Dryness in mouth
  • Difficulty in paying attention
  • Fatigue
  • Headache
  • Unsteadiness
  • Impaired coordination
  • Epigastric pain
  • Increased bronchial secretions
  • Dry mucous membrane
  • Constipation
  • Euphoria (feeling of intense excitement and happiness)
  • Abnormality of voluntary movements
  • Discomfort when urinating
  • Hypotension (low blood pressure)
  • Double vision
  • Early menstrual periods
  • Decreased appetite
  • Allergic sensitization
  • Photosensitivity
  • Dizziness
  • Diaphoresis
  • Erectile dysfunction

How to use Kuffdryl Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Kuffdryl 25mg Tablet may be taken with or without food.

How Kuffdryl Tablet works

Kuffdryl 25mg Tablet is an antihistaminic medication. It blocks the action of certain chemical messengers that are responsible for inflammation, congestion, itching, and other allergic reactions.

Quick tips

  • Avoid driving or operating dangerous machinery as it may decrease alertness.
  • Avoid consuming alcohol when taking the Kuffdryl 25mg Tablet, as it may cause excessive sleepiness or drowsiness.
  • Avoid driving or operating dangerous machinery as it may decrease alertness.
  • Avoid consuming alcohol when taking the Kuffdryl 25mg Tablet, as it may cause excessive sleepiness or drowsiness.

Safety advice

Alcohol

Alcohol

UNSAFE
Do not drink alcohol while you are taking this medicine. Kuffdryl 25mg Tablet may cause excessive drowsiness when taken with alcohol.
Pregnancy

Pregnancy

SAFE IF PRESCRIBED
Kuffdryl 25mg Tablet is generally considered safe to use during pregnancy. Animal studies do not indicate harmful effects. However, there are limited human studies.
Breast feeding

Breast feeding

CAUTION
Kuffdryl 25mg Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.
Larger doses or prolonged use of Kuffdryl 25mg Tablet may cause sleepiness and other effects in the baby
Driving

Driving

UNSAFE
Kuffdryl 25mg Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CONSULT YOUR DOCTOR
There is limited data available on the use of Kuffdryl 25mg Tablet in patients with kidney disease. Please consult your doctor.
However, talk to your doctor if you have any underlying kidney disease.
Liver

Liver

CAUTION
Kuffdryl 25mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Kuffdryl with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Moderate

Tramadol (Injection Route)

Do not drive or do anything requiring concentration or alertness until you know how the medicines affect you.
Moderate

Trihexyphenidyl (Injection Route)

Talk to your doctor if you notice any unusual symptoms.
Moderate

Clozapine (Oral Route)

Watch out for symptoms such as dry mouth, increased heart rate, urination difficulties, constipation, loss of appetite or nausea and consult your doctor if you experience them.
Moderate

Trihexyphenidyl (Oral Route)

Talk to your doctor if you notice any unusual symptoms.
Moderate

Tramadol (Oral Route)

Do not drive or do anything requiring concentration or alertness until you know how the medicines affect you.

Frequently asked questions

Kuffdryl 25mg Tablet contains Diphenhydramine and is used to relieve allergy symptoms such as sneezing, a runny nose, watery eyes, itching, and skin rashes. It may also be used to help prevent motion sickness and, in some cases, to manage short-term sleep difficulties. By reducing the effects of histamine in the body, it helps relieve allergy-related discomfort.
Kuffdryl 25mg Tablet contains Diphenhydramine, an antihistamine that blocks the action of histamine, a substance produced by the body during allergic reactions. This helps reduce symptoms such as sneezing, itching, watery eyes, and a runny nose. It also has a calming effect on the brain, which can cause drowsiness and may help with sleep and motion sickness.
Yes, the drowsiness caused by Diphenhydramine may help some people with short-term sleep difficulties. However, it should only be used as directed by your doctor and is not intended as a long-term treatment for insomnia. Persistent sleep problems may need further evaluation to identify the underlying cause.
If you are using Kuffdryl 25mg Tablet to help prevent motion sickness, it is generally taken before travelling so that the medicine has time to start working before symptoms develop. Follow your doctor's instructions or the directions provided with the medicine regarding the timing of the dose.
Yes, Kuffdryl 25mg Tablet can generally be taken with or without food. If you experience stomach discomfort after taking it, taking the medicine after food may feel more comfortable. Follow your doctor's instructions regarding the timing and frequency of doses.
Yes, drowsiness is one of the most common effects of Diphenhydramine. Some people may feel sleepy, less alert, or tired after taking the medicine. Because the degree of drowsiness varies between individuals, it is important to understand how the medicine affects you before performing activities that require attention.
Dry mouth and throat are common side effects of Kuffdryl 25mg Tablet. Drinking water regularly, chewing sugar-free gum, sucking on sugar-free candies, and maintaining good oral hygiene may help reduce discomfort. If dryness becomes severe or persistent, speak with your doctor.
People with glaucoma, asthma, or certain breathing problems should inform their doctor before using Kuffdryl 25mg Tablet. Diphenhydramine may worsen some symptoms or require additional caution in these conditions. Your doctor can determine whether the medicine is appropriate for you.
Yes, Kuffdryl 25mg Tablet may interact with several medicines, including medicines that cause drowsiness, certain antidepressants, antipsychotics such as Clozapine, and pain medicines such as Tramadol. Inform your doctor about all medicines and supplements you are taking to help avoid potentially harmful interactions.
Yes, Kuffdryl 25mg Tablet may help relieve itching, skin irritation, hives, and other allergy-related symptoms. By blocking the action of histamine, it can reduce the body's allergic response and improve comfort in people experiencing allergic reactions.
Avoid alcohol and avoid taking other medicines that can cause drowsiness unless advised by your doctor. Be cautious with activities requiring alertness, especially when starting treatment. Following the prescribed dose and avoiding unnecessary sedative medicines can help reduce the risk of side effects.

Fact Box

Chemical Class

Diphenylmethanes

Habit Forming

No

Therapeutic Class

RESPIRATORY

Action Class

First-Generation H1 Antihistamines

References

  1. McQuaid KR. Drugs Used in the Treatment of Gastrointestinal Diseases. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 1086.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 414-46.
  3. Central Drugs Standard Control Organisation (CDSCO). [Accessed 01 Apr. 2019] (online) Available from:
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User feedback

Others
60%
Motion sickness
20%
Insomnia
20%
Poor
60%
Average
40%
Dizziness
29%
Drowsiness
29%
Sleepiness
14%
No Side Effect
14%
Dryness in mouth
14%
With food
100%
Expensive
50%
Average
50%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Intas Pharmaceuticals Ltd
Address: Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.

Vendor Details

Country of origin: India
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