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Diphenhydramine

Written By Dr. Anuj SainiReviewed By Dr. Rajeev Sharma
Last updated 25 Nov 2025 | 09:34 AM (UTC)

Diphenhydramine Uses

Diphenhydramine is used in the treatment of nasal allergy symptoms, insomnia and motion sickness.

Available generics for Diphenhydramine

Order with generics and save upto 50%

How Diphenhydramine works

Diphenhydramine is an antihistaminic medication. It blocks the action of certain chemical messengers that are responsible for inflammation, congestion, itching, and other allergic reactions.

Common side effects of Diphenhydramine

Dizziness, Drowsiness, Dryness in mouth, Difficulty in paying attention, Fatigue, Headache, Sedation, Unsteadiness, Impaired coordination, Epigastric pain, Increased bronchial secretions, Dry mucous membrane, Constipation, Euphoria (feeling of intense excitement and happiness), Abnormality of voluntary movements, Discomfort when urinating, Hypotension (low blood pressure), Double vision, Diaphoresis, Erectile dysfunction, Early menstrual periods, Decreased appetite, Allergic sensitization, Photosensitivity
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Medicine brands for Diphenhydramine

Zendryl
Lupin Ltd
₹12 to ₹24
2 variant(s)
Zendryl
Novadryl
Elnova Pharma
₹23 to ₹23
1 variant(s)
Novadryl
Pediphen
Zap Healthcare Pvt Ltd
₹19 to ₹19
1 variant(s)
Pediphen
Vdfin
Voush Pharmaceutical Private Limited
₹41 to ₹41
1 variant(s)
Vdfin
Makdryl
Makmaul Labocare
₹48 to ₹48
1 variant(s)
Makdryl
Achoosom
Somnogen Pharmaceuticals Pvt Ltd
₹139 to ₹139
1 variant(s)
Achoosom
Dif
Wallace Pharmaceuticals Pvt Ltd
₹35 to ₹35
1 variant(s)
Dif
Adryl
Grievers Remedies
₹42 to ₹42
1 variant(s)
Adryl
Ranodryl
Sun Pharmaceutical Industries Ltd
₹27 to ₹27
1 variant(s)
Ranodryl

Expert advice for Diphenhydramine

  • Avoid driving or operating dangerous machinery as it may decrease alertness.
  • Avoid consuming alcohol when taking the Diphenhydramine, as it may cause excessive sleepiness or drowsiness.
  • Avoid driving or operating dangerous machinery as it may decrease alertness.
  • Avoid consuming alcohol when taking the Diphenhydramine, as it may cause excessive sleepiness or drowsiness.

Frequently asked questions for Diphenhydramine

No, it is an antihistaminic drug and not a blood thinner or narcotic
Benadryl is a trade name of product containing the drug Diphenhydramine
It is safe if used at prescribed doses for the prescribed duration as advised by your doctor
No, it should not be given to infants. Always follow doctor's advice regarding its use
Benadryl is an expectorant as guaifenesin is one of its components. And it is not an antibiotic
No, it is available in India
It is effective at prescribed doses for the prescribed duration and disease condition as advised by your doctor
Diphenhydramine tablet is used for the relief of short term sleeplessness. It can be used for cold and treatment of hives. Always follow doctor's advice regarding its use
Benadryl is used to treat sneezing, runny nose, itching, watery eyes, hives, rashes, itching, and other symptoms of allergies and the common cold. It is also used to suppress coughs, to treat motion sickness, to induce sleep, and to treat mild forms of Parkinson's disease. But, it is not used for eczema, sinus infection, and yeast infection. Always follow doctor's advice regarding its use
Yes, but taking other medicines may alter the effects of diphenhydramine. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required
Yes, but taking other medicines may alter the effects of Benadryl. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required
Yes, it makes you sleepy/drowsy. Always follow doctor's advice regarding its use
Diphenhydramine causing these side effects is rare or uncommon. However, consult your doctor if you experience any of these side effects
No it does not potentiate opiates
Benadryl causing these side effects is rare or uncommon. However, consult your doctor if you experience any of these side effects.
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