How it works
Diphenhydramine blocks the action of certain chemical messengers that are responsible for inflammation, congestion, itching, and other allergic reactions.
Common side effects
Nausea, Nervousness, Palpitations, Abnormal sensation in skin, Blurred vision, Confusion, Convulsion, Difficulty in paying attention, Dizziness, Drowsiness, Dry mouth, Shortness of breath, Difficulty in urination, Eye swelling, Lip swelling, Fatigue, Headache, Hypersensitivity reaction, Inability to empty the urinary bladder, Increased energy, Muscle twitching, Restlessness, Ringing in ear, Sedation, Tachycardia, Thickened respiratory tract secretions, Unsteadiness, Vomiting
- ₹68Cipla Ltd1 variant(s)
- ₹13 to ₹18Lupin Ltd2 variant(s)
- ₹37Wallace Pharmaceuticals Pvt Ltd1 variant(s)
- Do not drive or operate machinery after taking diphenhydramine as it may cause dizziness or drowziness.
- Avoid alcohol intake.
- Drink plenty of fluids to prevent dehydration.
- It is best to take this drug at bedtime as it makes you sleepy or drowsy.
Do not start or continue the diphenhydramine tablets:
- If you are allergic (hypersensitive) to diphenhydramine or any of the other ingredients of diphenhydramine tablet.
- If you have asthma, chronic obstructive pulmonary disorder (COPD) or other breathing disorder, narrow angle glaucoma, stomach ulcer or obstruction of the gut or bladder, porphyria, thyroid disorder, heart disease, prostrate problem.
- If you have an intolerance to some sugars like lactose.
- If you are pregnant or breastfeeding.
- If you have prostate problems.
Doctor’s advice should be considered before taking diphenhydramine tablets in case of any following disease conditions such as:
- Liver problems
- Long-term lung problems or difficulty breathing due to bronchitis.
- Difficulty passing urine
- Myasthenia gravis
- Rare hereditary problems of galactose intolerance, the Lap lactase deficiency or glucose-galactose malabsorption.
Frequently asked questions
Q. Is diphenhydramine a blood thinner/narcotic/water soluble?
No, it is an antihistaminic drug and not a blood thinner or narcotic
Q. Is diphenhydramine Hcl the same as Benadryl?
Benadryl is a trade name of product containing the drug diphenhydramine
Q. Is diphenhydramine hydrochloride/Benadryl safe?
It is safe if used at prescribed doses for the prescribed duration as advised by your doctor
Q. Is Benadryl safe for infants?
No, it should not be given to infants. Always follow doctor's advice regarding its use
Q. Is Benadryl an expectorant/antibiotic?
Benadryl is an expectorant as guaifenesin is one of its components. And it is not an antibiotic
Q. Is Benadryl banned in India?
No, it is available in India
Q. Is Benadryl effective?
It is effective at prescribed doses for the prescribed duration and disease condition as advised by your doctor
Q. Can you take diphenhydramine/ Benadryl for anxiety/cold/hives/bug bites/sleep?
Diphenhydramine tablet is used for the relief of short term sleeplessness. It can be used for cold and treatment of hives. Always follow doctor's advice regarding its use
Q. Can I take Benadryl for a rash/dry cough/cold/eczema/ sinus infection/yeast infection/headaches/sinus/motion sickness/ skin rash/itchy skin?
Benadryl is used to treat sneezing, runny nose, itching, watery eyes, hives, rashes, itching, and other symptoms of allergies and the common cold. It is also used to suppress coughs, to treat motion sickness, to induce sleep, and to treat mild forms of Parkinson's disease. But, it is not used for eczema, sinus infection, and yeast infection. Always follow doctor's advice regarding its use
Q. Can I take diphenhydramine with hydrocodone/dextromethorphan and guaifenesin/ acetaminophen/phenylephrine/tramadol/Zoloft/ doxylamine succinate/prednisone/ citalopram/Advil?
Yes, but taking other medicines may alter the effects of diphenhydramine. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required
Q. Can I take Benadryl with Zyrtec/Mucinex/Sudafed/ Tamiflu/ amoxicillin/Xanax/Advil/ azithromycin/Norco/robitussin?
Yes, but taking other medicines may alter the effects of Benadryl. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required
Q. Does diphenhydramine make you sleepy/drowsy?
Yes, it makes you sleepy/drowsy. Always follow doctor's advice regarding its use
Q. Does diphenhydramine cause Alzheimer's/depression/constipation/dementia/increase blood pressure?
Diphenhydramine causing these side effects is rare or uncommon. However, consult your doctor if you experience any of these side effects
Q. Does diphenhydramine potentiate opiates?
No it does not potentiate opiates
Q. Does Benadryl make you sleepy/high/ raise blood pressure/weight gain?
Benadryl causing these side effects is rare or uncommon. However, consult your doctor if you experience any of these side effects.