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Trihexyphenidyl

Information

Uses

Trihexyphenidyl is used in parkinson's disease and drug induced abnormal movements.

How it works

Trihexyphenidyl works by decreasing the activity of excess accetycholine in brain. This improves muscle control and reduces stiffness

Common side effects

Dry mouth, Nausea, Vomiting, Constipation, Blurred vision

Available Medicine

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Expert advice

  • Trihexyphenidyl should be used cautiously in patients with high blood pressure (hypertension), heart, kidney or liver disorders, glaucoma (increase in pressure inside the eye causing gradual loss of vision if left untreated), obstructive disease of the digestive, genital and urinary tracts, myasthenia gravis (a disease characterized by very weak and unusually tired muscles) and in elderly men with enlarged prostate gland (prostatic hypertrophy).
  • Seek immediate medical attention if you experience psychiatric symptoms such as – confusion, delusions (believing in things that are not real) and hallucinations (seeing or hearing things that that are not real). Extreme caution should be taken in elderly.
  • Trihexyphenidyl is not recommended for use in patients with tardive dyskinesia (involuntary movement of face and jaw) and in children under 18 years of age.
  • Trihexyphenidyl is not recommended as prophylaxis (preventive treatment) for drug-induced parkinsonism.
  • Avoid abrupt discontinuation of treatment as it can result in worsening of symptoms of Parkinson’s disease or emergence of life-threatening complications (neuroleptic malignant syndrome).
  • Take precautions while driving or operating machinery as trihexyphenidyl can impair mental and physical abilities.
  • Use trihexyphenidyl with caution in hot weather as it can increase susceptibility to heat stroke (symptoms: very high fever, inability to bear heat, nausea, vomiting etc.)
  • Tell your doctor if you are pregnant or planning to become pregnant or are breastfeeding.

Frequently asked questions

Trihexyphenidyl

Q.

What is trihexyphenidyl used for?
Trihexyphenidyl is used to in the management of Parkinson's disease as an add-on medicine along with other medicines. It helps by improving muscle control and reducing the stiffness of the muscle so that they can move naturally. Trihexyphenidyl can also be used to treat movement disorders (extreme restlessness, involuntary movements or muscle spasms) which can be caused by certain drugs.

Q.

How does trihexyphenidyl work?
Trihexyphenidyl works by blocking the action of a chemical messenger known as acetylcholine on the nerves of the smooth muscles; thereby, reducing the muscle spasm (involuntary contraction of a muscle or group of muscles), tremor (uncontrolled shaking) and excessive salivation associated with Parkinson's disease.

Q.

Is trihexyphenidyl a narcotic substance?
No, trihexyphenidyl is not a narcotic substance. Trihexyphenidyl is an antispasmodic(muscle relaxing) medicine and belongs to a group of medicines known as anticholinergics.

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Q.

Is trihexyphenidyl addictive?
Trihexyphenidyl may be associated with abuse (due to its hallucinogenic or euphoriant properties, common to all anti-cholinergic drugs) if given in sufficient amounts.

Q.

Is trihexyphenidyl a MAO inhibitor?
No, trihexyphenidyl is not a MAO inhibitor. Trihexyphenidyl is an antispasmodic (muscle relaxing) drug and belongs to a group of medicines known as anticholinergics.

Q.

Is trihexyphenidyl safe?
Trihexyphenidyl is a safe medicine if used at prescribed doses for the prescribed duration as advised by the doctor.

Q.

Is trihexyphenidyl a controlled substance?
No, trihexyphenidyl is not classified as a controlled substance. However, the possibility of abuse should be borne in mind due to its stimulant and euphoriant properties.

Q.

Is trihexyphenidyl FDA approved?
Trihexyphenidyl is an approved medicine by the Food and Drug Administration (FDA).

Q.

Does trihexyphenidyl get you high?
Trihexyphenidyl has been reported to get you a high. Please use this drug only for prescribed duration in doses as recommended by your doctor.

Q.

Does trihexyphenidyl cause weight gain?
Trihexyphenidyl has not been seen to cause weight gain. However, weight loss has been reported with trihexyphenidyl in children. Please consult your doctor in case you experience an unexpected change in your weight while you are taking trihexyphenidyl.


Content on this page was last updated on 04 April, 2017, by Dr. Varun Gupta (MD Pharmacology)