Knilonat 200 Capsule

Nilotinib (200mg)

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Knilonat 200 Capsule is used in the treatment of blood cancer (chronic myeloid leukaemia). It is used in patients whose disease could not be treated with other medications for leukaemia or who cannot take these medications because of side effects.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 04 Apr 2026 | 01:00 AM (IST)

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General Information

Contains

Nilotinib (200mg)

Marketer

Natco Pharma Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Knilonat 200 Capsule should be taken on an empty stomach, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Headache, nausea, abdominal pain, and rash are very common side effects of this medicine. If you experience severe diarrhea, consult with your doctor or drink plenty of fluids while on treatment. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver and blood uric acid levels and blood sugar or fat level in the body.

Before taking it, tell your doctor if have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. Use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Knilonat Capsule

Blood cancer (Chronic myeloid leukaemia)

Benefits of Knilonat Capsule

Blood cancer (Chronic myeloid leukaemia)
Chronic myeloid leukaemia (CML) is a type of blood cancer in which the bone marrow produces abnormal white blood cells that grow uncontrollably and interfere with normal blood cell production. Knilonat 200 Capsule helps slow or stop the growth of these abnormal cells, allowing healthy blood cells to develop and improving blood counts. This helps manage the disease, reduces related symptoms such as fatigue and infections, and supports long-term disease control.

Side effects of Knilonat Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Knilonat

Fatigue
Muscle pain
Abdominal pain
Rash
Headache
Nausea
Itching
Hair loss

How to use Knilonat Capsule

Take this medicine in the dose and duration as advised by your doctor. Knilonat 200 Capsule is to be taken on an empty stomach.

How Knilonat Capsule works

Knilonat 200 Capsule is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.

All substitutes for Knilonat 200 Capsule

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Take Knilonat 200 Capsule on an empty stomach and avoid food for at least 2 hours before and 1 hour after each dose.
Swallow Knilonat 200 Capsule whole with water and do not crush, chew, or split it.
Avoid grapefruit or grapefruit juice, as it can increase side effects by interfering with the medicine.
Stick to regular checkups and blood tests, as this medicine needs close monitoring.
Let your doctor know right away if you notice sudden weight gain, swelling, or shortness of breath.
Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if it doesn't stop or if you find blood in your stools.
Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for a month after you stop taking Knilonat 200 Capsule.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Knilonat 200 Capsule. Please consult your doctor.

Pregnancy

UNSAFE

Knilonat 200 Capsule is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

UNSAFE

Knilonat 200 Capsule is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

Knilonat 200 Capsule may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CONSULT YOUR DOCTOR

There is limited data available on the use of Knilonat 200 Capsule in patients with kidney disease. Please consult your doctor.

Liver

CAUTION

Knilonat 200 Capsule should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Knilonat with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Amiodarone (Oral Route)

Do not consume Amiodarone with Nilotinib.

Life-threatening

Aripiprazole (Oral Route)

Do not consume Aripiprazole with Nilotinib.

Life-threatening

Escitalopram Oxalate (Oral Route)

Do not consume Escitalopram Oxalate with Nilotinib.

Life-threatening

Haloperidol (Oral Route)

Do not consume Haloperidol with Nilotinib.

Life-threatening

Ondansetron (Oral Route)

Do not consume Ondansetron with Nilotinib.

Frequently asked questions

What is Knilonat 200 Capsule used for?

Knilonat 200 Capsule is a prescription medicine used to treat a type of blood cancer called Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). It is used in both newly diagnosed patients and those who did not respond well to other anti-cancer treatments like imatinib.

How does Knilonat 200 Capsule work in treating leukemia?

Knilonat 200 Capsule is a tyrosine kinase inhibitor (TKI). It works by blocking abnormal signals in cancer cells, stopping them from growing. This helps reduce the number of leukemia cells in your body.

Who should not take Knilonat 200 Capsule?

Individuals should not take Knilonat 200 Capsule if they have low potassium or magnesium levels, a history of heart rhythm problems (QT prolongation), severe liver problems, or a known allergy to nilotinib or any ingredients present in Knilonat 200 Capsule.

What are the most serious side effects of Knilonat 200 Capsule?

The serious side effects of Knilonat 200 Capsule include sudden cardiac death, QT interval prolongation (heart rhythm issues), liver failure, pancreatitis, and severe low blood counts. Call your doctor right away if you feel faint, dizzy, have chest pain, or severe stomach pain.

What should I tell my doctor before starting Knilonat 200 Capsule?

Before starting Knilonat 200 Capsule, let the doctor know if there are heart, liver, or kidney issues. Also, inform if taking medications that affect the heartbeat or liver. Mention if pregnant, planning pregnancy, or breastfeeding.

Can Knilonat 200 Capsule affect my blood cell counts?

Yes, Knilonat 200 Capsule can cause low red cells (anemia), white cells (neutropenia), or platelets (thrombocytopenia). Your doctor will monitor your blood regularly during treatment.

Can I take Knilonat 200 Capsule with food or supplements?

It is advised to avoid all food 2 hours before and 1 hour after taking Knilonat 200 Capsule, as food increases Knilonat 200 Capsule absorption, which can raise the risk of side effects. Always take it on an empty stomach as directed. Also, avoid grapefruit, St. John's Wort, and calcium or magnesium supplements near your dose unless prescribed by your doctor.

Can I ever stop taking Knilonat 200 Capsule?

Possibly, if Knilonat 200 Capsule has been taken for at least 3 years and leukemia is in deep molecular remission (can no longer detect cancer-related genetic markers such as BCR-ABL1 in leukemia in the blood), the doctor may consider discontinuing treatment. Frequent monitoring will be needed to ensure the cancer does not return.

Fact Box

Chemical Class

Benzamide derivative

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Tyrosine Kinase Inhibitors (TKIs)

Related lab tests

Bcr-Abl Gene Translocation (Qualitative)

Bcr-Abl Gene Translocation (Quantitative)

Complete Blood Count

Peripheral Smear Examination

References

Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1732-34.
Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 953.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 980-82.
Nilotinib [Summary of Product Characteristics]. Dublin, Ireland: Novartis Europharm Limited.

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Natco Pharma Ltd
Address: Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Knilonat 200 Capsule. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

Why we need a prescription?

Knilonat 200 Capsule

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Knilonat Capsule

Benefits of Knilonat Capsule

Side effects of Knilonat Capsule

How to use Knilonat Capsule

How Knilonat Capsule works

All substitutes for Knilonat 200 Capsule

Tasigna 200mg Capsule

Nilocap 200mg Capsule

Ninlib 200mg Capsule

Nilosure 200mg Capsule

Ninlib Capsule

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Amiodarone (Oral Route)

Aripiprazole (Oral Route)

Escitalopram Oxalate (Oral Route)

Haloperidol (Oral Route)

Ondansetron (Oral Route)

Frequently asked questions

What is Knilonat 200 Capsule used for?

How does Knilonat 200 Capsule work in treating leukemia?

Who should not take Knilonat 200 Capsule?

What are the most serious side effects of Knilonat 200 Capsule?

What should I tell my doctor before starting Knilonat 200 Capsule?

Can Knilonat 200 Capsule affect my blood cell counts?

Can I take Knilonat 200 Capsule with food or supplements?

Can I ever stop taking Knilonat 200 Capsule?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Bcr-Abl Gene Translocation (Qualitative)

Bcr-Abl Gene Translocation (Quantitative)

Complete Blood Count

Peripheral Smear Examination

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

Related/Popular tests