Knilonat 200 Capsule
Product introduction
Knilonat 200 Capsule is used in the treatment of blood cancer (chronic myeloid leukaemia). It is used in patients whose disease could not be treated with other medications for leukaemia or who cannot take these medications because of side effects.
Knilonat 200 Capsule should be taken on an empty stomach, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
Headache, nausea, abdominal pain, and rash are very common side effects of this medicine. If you experience severe diarrhea, consult with your doctor or drink plenty of fluids while on treatment. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver and blood uric acid levels and blood sugar or fat level in the body.
Before taking it, tell your doctor if have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. Use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Uses of Knilonat Capsule
Benefits of Knilonat Capsule
In Blood cancer (Chronic myeloid leukaemia)
Chronic myeloid leukaemia (CML) is a type of blood cancer in which the bone marrow produces abnormal white blood cells that grow uncontrollably and interfere with normal blood cell production. Knilonat 200 Capsule helps slow or stop the growth of these abnormal cells, allowing healthy blood cells to develop and improving blood counts. This helps manage the disease, reduces related symptoms such as fatigue and infections, and supports long-term disease control.
Side effects of Knilonat Capsule
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Knilonat
- Headache
- Nausea
- Abdominal pain
- Rash
- Itching
- Hair loss
- Muscle pain
- Fatigue
How to use Knilonat Capsule
Take this medicine in the dose and duration as advised by your doctor. Knilonat 200 Capsule is to be taken empty stomach.
How Knilonat Capsule works
Knilonat 200 Capsule is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.
Safety advice
Alcohol
SAFE
Consuming alcohol with Knilonat 200 Capsule does not cause any harmful side effects.
Pregnancy
CONSULT YOUR DOCTOR
Knilonat 200 Capsule is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding
UNSAFE
Knilonat 200 Capsule is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving
UNSAFE
Knilonat 200 Capsule may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
SAFE IF PRESCRIBED
Knilonat 200 Capsule is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Knilonat 200 Capsule may not be needed in these patients. Please consult your doctor.
Liver
CAUTION
Knilonat 200 Capsule should be used with caution in patients with liver disease. Dose adjustment of Knilonat 200 Capsule may be needed. Please consult your doctor.
What if you forget to take Knilonat Capsule?
If you miss a dose of Knilonat 200 Capsule, skip it and continue with your normal schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
Knilonat 200 Capsule
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Quick tips
- Take Knilonat 200 Capsule on an empty stomach and avoid food for at least 2 hours before and 1 hour after each dose.
- Swallow Knilonat 200 Capsule whole with water and do not crush, chew, or split it.
- Avoid grapefruit or grapefruit juice, as it can increase side effects by interfering with the medicine.
- Stick to regular checkups and blood tests, as this medicine needs close monitoring.
- Let your doctor know right away if you notice sudden weight gain, swelling, or shortness of breath.
- Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if it doesn't stop or if you find blood in your stools.
- Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for a month after you stop taking Knilonat 200 Capsule.
Fact Box
Chemical Class
Aminopyrimidine Derivative
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Action Class
Tyrosine Kinase Inhibitors (TKIs)
Interaction with drugs
Taking Knilonat with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Do not consume Escitalopram Oxalate with Nilotinib.
Concomitant use may affect heart rhythm and may be fatal.
Do not consume Haloperidol with Nilotinib.
Concomitant use may affect heart rhythm and may be fatal.
Do not consume Amiodarone with Nilotinib.
Concomitant use may affect heart rhythm and may be fatal.
Do not consume Aripiprazole with Nilotinib.
Both Aripiprazole and Nilotinib can affect heart rhythm and if taken together this may be fatal.
Do not consume Ondansetron with Nilotinib.
Concomitant use may affect heart rhythm and may be fatal.
Patient concerns
FAQs
What is Knilonat 200 Capsule used for?
Knilonat 200 Capsule is a prescription medicine used to treat a type of blood cancer called Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). It is used in both newly diagnosed patients and those who did not respond well to other anti-cancer treatments like imatinib.
How does Knilonat 200 Capsule work in treating leukemia?
Knilonat 200 Capsule is a tyrosine kinase inhibitor (TKI). It works by blocking abnormal signals in cancer cells, stopping them from growing. This helps reduce the number of leukemia cells in your body.
Who should not take Knilonat 200 Capsule?
Individuals should not take Knilonat 200 Capsule if they have low potassium or magnesium levels, a history of heart rhythm problems (QT prolongation), severe liver problems, or a known allergy to nilotinib or any ingredients present in Knilonat 200 Capsule.
What are the most serious side effects of Knilonat 200 Capsule?
The serious side effects of Knilonat 200 Capsule include sudden cardiac death, QT interval prolongation (heart rhythm issues), liver failure, pancreatitis, and severe low blood counts. Call your doctor right away if you feel faint, dizzy, have chest pain, or severe stomach pain.
What should I tell my doctor before starting Knilonat 200 Capsule?
Before starting Knilonat 200 Capsule, let the doctor know if there are heart, liver, or kidney issues. Also, inform if taking medications that affect the heartbeat or liver. Mention if pregnant, planning pregnancy, or breastfeeding.
Can Knilonat 200 Capsule affect my blood cell counts?
Yes, Knilonat 200 Capsule can cause low red cells (anemia), white cells (neutropenia), or platelets (thrombocytopenia). Your doctor will monitor your blood regularly during treatment.
Can I take Knilonat 200 Capsule with food or supplements?
It is advised to avoid all food 2 hours before and 1 hour after taking Knilonat 200 Capsule, as food increases Knilonat 200 Capsule absorption, which can raise the risk of side effects. Always take it on an empty stomach as directed. Also, avoid grapefruit, St. John's Wort, and calcium or magnesium supplements near your dose unless prescribed by your doctor.
Can I ever stop taking Knilonat 200 Capsule?
Possibly, if Knilonat 200 Capsule has been taken for at least 3 years and leukemia is in deep molecular remission (can no longer detect cancer-related genetic markers such as BCR-ABL1 in leukemia in the blood), the doctor may consider discontinuing treatment. Frequent monitoring will be needed to ensure the cancer does not return.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1732-34.
- Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 953.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 980-82.
Marketer details
Name: Natco Pharma Ltd
Address: Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Country of origin: India
Expires on or after: July, 2026
A licensed vendor partner from your nearest location will deliver Knilonat 200 Capsule. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
Expires on or after: July, 2026
A licensed vendor partner from your nearest location will deliver Knilonat 200 Capsule. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
In case of any issues, contact us
Email ID: [email protected]Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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MRP₹1125 21% OFF
₹889
Inclusive of all taxes
10.0 capsules in 1 strip
New GST benefit included in this MRP, may differ from label
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