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MRP: Rs. 10023.30 for 1 packet(s) (60 tablets each)
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Composition for ISENTRESS

Raltegravir(400 mg)

food interaction for ISENTRESS

alcohol interaction for ISENTRESS

pregnancy interaction for ISENTRESS

lactation interaction for ISENTRESS

It can be taken with or without food, but it is better to take Isentress 400mg tablet at a fixed time.
Interaction with alcohol is unknown. Please consult your doctor.
Isentress 400mg tablet may be unsafe to use during pregnancy.
Either animal studies have shown adverse effect on fetus and there are no human studies or studies in human and animals are not available. It should be given only if potential benefits justifies risk to the fetus. Please consult your doctor.
Unknown. Human and animal studies are not available. Please consult your doctor.


Raltegravir(400 mg)


Isentress 400mg tablet is used for the treatment of human immunodeficiency virus (HIV) infection, along with other antiretroviral agents.

How it works

Isentress 400mg tablet belongs to a class of HIV integrase inhibitors. It works by inhibiting the action of an enzyme called integrase which is essential for the multiplication and survival of the virus (viral replication), thereby reducing HIV causing virus in the body.

Common side effects

Nausea, Nightmare, Liver enzyme increased, Abdominal pain, Abdominal swelling, Abnormal behavior, Abnormal dreams, Abnormal white blood cells, Depression, Diarrhoea, Dizziness, Fever, Headache, Indigestion, Insomnia, Loss of appetite, Muscle weakness, Rash, Vertigo, Vomiting, Fatigue, Restlessness, Anxiety


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Expert advice for ISENTRESS

  • Do consult your doctor before taking raltegravir if you have phenylketonuria (a serious hereditary disorder), a medical history of depression or any psychiatric illness, severe liver disorders or muscle disorders (myopathy or rhabdomyolysis).
  • Contact your doctor immediately if you notice stiffness, pain and difficulty in movement of joints or unexplained muscle pain, weakness and tenderness or notice signs of any infection such as fever while on treatment with raltegravir.
  • Avoid taking antacids containing aluminum or magnesium within 2 hours before or 2 hours after you take raltegravir.
  • Do not operate machines, drive or cycle if you feel dizzy after taking raltegravir.
  • Raltegravir does not prevent the spread of HIV virus to others through blood or sexual contact. Take the required precautions to prevent transmission.
  • Continue taking raltegravir even if you feel well, as skipping the medicine may worsen your condition and may lead to resistance to treatment.
  • You must be aware that your body fat may increase or move to different areas of your body such as your breasts and upper back while on raltegravir therapy.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding. You must receive proper treatment for HIV to avoid passing of the infection to your baby.

Frequently asked questions for ISENTRESS


Q. Is raltegravir a protease inhibitor?
No. Raltegravir is an anti HIV drug. It does not have any known inhibitory effect on enzyme protease.
Q. What is Raltegravir used for?
Raltegravir is used for the treatment for human immunodeficiency virus (HIV) infection.
Q. How does raltegravir work? How does raltegravir inhibit HIV viral replication?
Raltegravir works by inhibiting the action of an enzyme called integrase which is essential for the multiplication and survival of the virus (viral replication), thereby reducing HIV causing virus in the body.


Content on this page was last updated on 03 July, 2015, by Dr. Varun Gupta (MD Pharmacology)