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12 Jun 2019 | 06:10 PM (IST)
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Donep Syrup

Prescription Required
SALT COMPOSITION

Overview

Uses of Donep Syrup

Donep Syrup side effects

Common
  • Nausea
  • Vomiting
  • Loss of appetite
  • Fatigue
  • Insomnia (difficulty in sleeping)
  • Diarrhea
  • Muscle cramp

How to use Donep Syrup

Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Donep Syrup may be taken with or without food, but it is better to take it at a fixed time.

How Donep Syrup works

Memory loss in Alzheimer’s disease occurs due to disturbances of signal transmission in the brain. Donep Syrup is a cholinesterase inhibitor. It works by increasing the levels of a chemical messenger (acetylcholine) involved in transmmission of nerve signals. This improves memory and thinking.

Donep Syrup related warnings

Alcohol
CAUTION
It is unsafe to consume alcohol with Donep Syrup.
Pregnancy
WEIGH RISKS VS BENEFITS
Donep Syrup may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the fetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Lactation
CAUTION
Donep Syrup is probably unsafe to use during lactation. Limited human data suggest that the drug could represent a significant risk to the baby.
Driving
Do not drive unless you are feeling well.
Alzheimer’s disease may impair your ability to drive unless your doctor tells you that it is safe to do so. Also, your medicine can cause tiredness, dizziness and muscle cramp.
Kidney
Donep Syrup is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Donep Syrup may not be needed in these patients. Please consult your doctor.
Liver
CAUTION
Donep Syrup should be used with caution in patients with liver disease. Dose adjustment of Donep Syrup may be needed. Please consult your doctor.

What if you miss a dose of Donep Syrup?

If you miss a dose of Donep Syrup, skip it and continue with your normal schedule. Do not double the dose.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
No alternate brands found for this medicine

Expert Advice

  • You have been prescribed Donep Syrup to slow down the progression of Alzheimer's disease.
  • It does not cure Alzheimer's but may help with brain function and doing daily activities.
  • Take it with food to avoid an upset stomach.
  • It may cause diarrhea, nausea, and vomiting. Drink plenty of fluids to keep yourself hydrated while taking Donep Syrup.
  • Monitor your body weight regularly as both Donep Syrup and  Alzheimer's disease can cause weight loss.
  • Do not drive or do anything that requires mental focus until you know how Donep Syrup affects you.
  • Inform your doctor if you develop muscle tremors, especially if you have Parkinson’s disease.

Interaction with Drugs

Taking Donep with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Flotin, Serodep
MODERATE
Brand(s): Leparox, Prx
MODERATE
Brand(s): Kopram
MODERATE
Brand(s): Zosert
MODERATE
Brand(s): Fungis, EF Z, Rocflu
MINOR
Brand(s): Indizole, Itraspan, Itzo
MINOR

Patient Concerns

Questions Related to Donep

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My father is suffering from alzheimer disease. Which medicine should I give or which doctor to approach? Neurologist or Pyschiatrist.
Dr. Vikas Sharma
Neurologist
Neurologist Donep 5 mg daily
Please suggest treatment of cortical atrophy Dizziness ,vomiting from last 2days chief complaints. History of hypertension
Dr. Vikas Sharma
Neurologist
Tab donep 5 mg daily
arrow
Do you have any questions related to Donep Syrup?

User Feedback


FAQs

Q. Why is Donep taken at night?

Donep is recommended to be taken before going to bed to reduce gastrointestinal side effects or nausea, which is commonly seen in some patients in the first few weeks of treatment.

Q. Do the gastrointestinal side effects due to Donep persist for a long time?

Gastrointestinal side effects may appear during the first few weeks of treatment with Donep. This can be minimized by taking Donep at bedtime and with food. Generally, these side effects are mild and disappear within a few weeks with continued treatment.

Q. How long does it take for Donep to start working?

Within the first month of treatment with Donep, you may experience improvement in thinking and remembering (cognitive effect). However, it may take about 12 weeks to see the full benefits.

Q. When should Donep be stopped?

Do not stop Donep without consulting your doctor. This medicine only helps to control your condition but does not cure it. Therefore, it may take several weeks to show benefits, so do not be discouraged if you do not see an improvement straight away. But, in case your condition starts worsening and you feel that it is no longer helping you, then you should consult a doctor before stopping it.

Q. For how long does Donep stay in your system?

Donep gets removed from the body very slowly. It takes about two weeks or more for Donep to be completely removed from the system.

Q. Does Donep cause depression?

No, Donep does not cause depression. If you are experiencing symptoms, then it could be due to existing Alzheimer’s disease.

Q. What if I take more than the prescribed dose of Donep?

Taking more than the recommended dose of Donep may cause vomiting, increased sweating or saliva production, slow heartbeat, dizziness, difficulty in breathing, seizures or fits, weakness, and inability to control your bowel motions or passing of urine (incontinence). You should seek immediate help from a doctor or emergency service of a nearby hospital.

Q. I have been taking indomethacin for arthritis. Can I take Donep?

Donep does not interfere with the working of indomethacin, but indomethacin individually increases the risk of stomach bleeding when taken for a long time. Therefore, if you experience any symptoms of stomach bleeding, consult your doctor immediately.

Q. Does Donep cause hallucinations?

Hallucinations are a common side effect of Donep, though not everyone is affected. Other common psychiatric side effects include agitation, aggressive behavior, nightmares, and abnormal dreams.

Q. Who should not take Donep?

Donep should not be taken by patients who have hypersensitivity to Donep hydrochloride, piperidine derivatives, or to any active ingredients used in the medicine. Also, it should not be used during pregnancy unless clearly necessary.

Q. Can it cause insomnia?

Yes, insomnia (sleeplessness) is a common side effect of Donep. Dizziness and fainting can also be seen as common side effects. Though these side effects are common, they do not occur in everyone.

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Disclaimer: 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
References
  1. Stahl SM, editor. Donepezil. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 199-202.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 426-27.
  3. Donepezil hydrochloride. Woodcliff Lake, New Jersey: Eisai Inc.; 1996 [revised Feb. 2012]. [Accessed 25 Jan. 2019] (online) Available from:External Link
  4. Donepezil. Hatfield, Hertfordshire: Eisai Ltd.; 1997 [revised 11 May 2018]. [Accessed 25 Jan. 2019] (online) Available from:External Link
  5. Central Drugs Standard Control Organisation (CDSCO). [Accessed 22 Mar. 2019] (online) Available from:External Link
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