Donep 10 Tablet

Prescription Required
SALT COMPOSITION
Storage
Store at room temperature (10-30°C)
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Introduction

Donep 10 Tablet is used to treat mild to moderate dementia in Alzheimer’s disease, a progressive illness that gradually affects memory and thinking. It does not cure this illness but may help improve memory, awareness, and other symptoms.

Your doctor will explain how to take Donep 10 Tablet. Follow the instructions carefully to get the most benefit. The dose may change from time to time to suit your individual needs. You may take it with food, preferably at night before going to bed. It can take up to a few weeks for symptoms to improve so keep taking your medicine regularly. You should not stop taking this medicine without consulting your doctor.

Some common side effects of this medicine include nausea, diarrhea, insomnia, vomiting, muscle cramps, fatigue, and weight loss (anorexia). Drink plenty of fluids to keep yourself hydrated. You may have side effects more often when you start your treatment or when your dose is increased. Usually, the side effects will slowly go away as your body gets used to the Donep 10 Tablet. If they are severe or will not go away, you should contact your doctor.

Before using Donep 10 Tablet, you should tell your doctor if you have ever had heart problems, stomach ulcers, epilepsy, or asthma. It may also affect, or be affected by, some other drugs you are using so let your doctor know what these are to be safe. During pregnancy, this medicine should only be taken if it is advised.

Uses of Donep Tablet

Benefits of Donep Tablet

In Alzheimer's disease

In people with Alzheimer’s disease, certain nerve cells die in the brain. This results in lower levels of a chemical called acetylcholine which helps nerve cells to communicate with each other. This leads to symptoms of dementia such as memory loss, confusion, disorientation, problems with speech and language, and personality changes. Donep 10 Tablet increases the amount of acetylcholine and helps brain cells to communicate. It can, therefore, improve some of the symptoms such as memory, awareness, and the ability to carry out daily functions for a time. However, it is not a cure. You should use the medicine exactly as prescribed. It can take several weeks for your symptoms to improve; so keep using the medicine even if you do not think it is working.

Side effects of Donep Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Donep

  • Nausea
  • Diarrhea
  • Insomnia (difficulty in sleeping)
  • Vomiting
  • Muscle cramp
  • Fatigue
  • Weight loss

How to use Donep Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Donep 10 Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Donep Tablet works

Memory loss in Alzheimer’s disease occurs due to disturbances of signal transmission in the brain. Donep 10 Tablet is a cholinesterase inhibitor. It works by increasing the levels of a chemical messenger (acetylcholine) involved in transmmission of nerve signals. This improves memory and thinking.

Safety Advice

Alcohol
UNSAFE
It is unsafe to consume alcohol with Donep 10 Tablet.
Pregnancy
CONSULT YOUR DOCTOR
Donep 10 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breastfeeding
CONSULT YOUR DOCTOR
Donep 10 Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Donep 10 Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
SAFE IF PRESCRIBED
Donep 10 Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Donep 10 Tablet may not be needed in these patients. Please consult your doctor.
Liver
CAUTION
Donep 10 Tablet should be used with caution in patients with liver disease. Dose adjustment of Donep 10 Tablet may be needed. Please consult your doctor.

What if you forget to take Donep Tablet?

If you miss a dose of Donep 10 Tablet, skip it and continue with your normal schedule. Do not double the dose.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Donep 10 Tablet
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Quick Tips

  • You have been prescribed Donep 10 Tablet to slow down the progression of Alzheimer's disease.
  • It does not cure Alzheimer's disease but may help improve brain function and ability to do daily activities.
  • Take it with or without food, preferably at night before going to bed.
  • It may cause diarrhea, nausea, and vomiting. Drink plenty of fluids to keep yourself hydrated while taking Donep 10 Tablet.
  • Monitor your body weight regularly as both Donep 10 Tablet and  Alzheimer's disease can cause weight loss.
  • Do not drive or do anything that requires mental focus until you know how Donep 10 Tablet affects you.
  • Be cautious while taking this medicine if you suffer from peptic ulcer as it may cause vomiting, stomach bleeding, stomach pain, or discomfort.
  • Inform your doctor if you develop muscle tremors, especially if you have Parkinson’s disease.
  • Inform your doctor if you experience seizures or convulsions while taking this medicine.

Fact Box

Chemical Class
Carbamate Derivative
Habit Forming
No
Therapeutic Class
NEURO CNS
Action Class
Cholinesterase inhibitors - Alzheimer's disease

Interaction with Drugs

Taking Donep with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Atroped, Atronir, Mydrat-J
LIFE-THREATENING
Brand(s): Bigspas
LIFE-THREATENING
Brand(s): Cholipan, Hyozen, Buscotag
LIFE-THREATENING
Brand(s): OB
LIFE-THREATENING

Patient Concerns

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My father is suffering from alzheimer disease. Which medicine should I give or which doctor to approach? Neurologist or Pyschiatrist.
Dr. Vikas Sharma
Neurology
Neurologist Donep 5 mg daily
The patient has cerebral atrophy and hypertension. He is taking phenitoy,phenobarbitone,AHT and statin with aspirins. He had a brain stroke and fits 4 times. He remains confused. Also has imbalance. Advice him the best possible treatment. Thanks. Please advise the best possible treatment.Thanks.
Dr. Vikas Sharma
Neurology
start tab donep 5 mg daily; pls show to neurologist
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Do you have any questions related to Donep 10 Tablet ?

User Feedback


FAQs

Q. Why is Donep 10 Tablet taken at night?

Donep 10 Tablet is recommended to be taken before going to bed to reduce gastrointestinal side effects or nausea, which is commonly seen in some patients in the first few weeks of treatment.

Q. Do the gastrointestinal side effects due to Donep 10 Tablet persist for a long time?

Gastrointestinal side effects may appear during the first few weeks of treatment with Donep 10 Tablet. This can be minimized by taking Donep 10 Tablet at bedtime and with food. Generally, these side effects are mild and disappear within a few weeks with continued treatment.

Q. How long does it take for Donep 10 Tablet to start working?

Within the first month of treatment with Donep 10 Tablet, you may experience improvement in thinking and remembering (cognitive effect). However, it may take about 12 weeks to see the full benefits.

Q. When should Donep 10 Tablet be stopped?

Do not stop Donep 10 Tablet without consulting your doctor. This medicine only helps to control your condition but does not cure it. Therefore, it may take several weeks to show benefits, so do not be discouraged if you do not see an improvement straight away. But, in case your condition starts worsening and you feel that it is no longer helping you, then you should consult a doctor before stopping it.

Q. For how long does Donep 10 Tablet stay in your system?

Donep 10 Tablet gets removed from the body very slowly. It takes about two weeks or more for Donep 10 Tablet to be completely removed from the system.

Q. Does Donep 10 Tablet cause depression?

No, Donep 10 Tablet does not cause depression. If you are experiencing symptoms, then it could be due to existing Alzheimer’s disease.

Q. What if I take more than the prescribed dose of Donep 10 Tablet?

Taking more than the recommended dose of Donep 10 Tablet may cause vomiting, increased sweating or saliva production, slow heartbeat, dizziness, difficulty in breathing, seizures or fits, weakness, and inability to control your bowel motions or passing of urine (incontinence). You should seek immediate help from a doctor or emergency service of a nearby hospital.

Q. I have been taking indomethacin for arthritis. Can I take Donep 10 Tablet?

Donep 10 Tablet does not interfere with the working of indomethacin, but indomethacin individually increases the risk of stomach bleeding when taken for a long time. Therefore, if you experience any symptoms of stomach bleeding, consult your doctor immediately.

Q. Does Donep 10 Tablet cause hallucinations?

Hallucinations are a common side effect of Donep 10 Tablet, though not everyone is affected. Other common psychiatric side effects include agitation, aggressive behavior, nightmares, and abnormal dreams.

Q. Who should not take Donep 10 Tablet?

Donep 10 Tablet should not be taken by patients who have hypersensitivity to Donep 10 Tablet hydrochloride, piperidine derivatives, or to any active ingredients used in the medicine. Also, it should not be used during pregnancy unless clearly necessary.

Q. Can it cause insomnia?

Yes, insomnia (sleeplessness) is a common side effect of Donep 10 Tablet. Dizziness and fainting can also be seen as common side effects. Though these side effects are common, they do not occur in everyone.

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1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Stahl SM, editor. Donepezil. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 199-202.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 426-27.
  3. Donepezil hydrochloride. Woodcliff Lake, New Jersey: Eisai Inc.; 1996 [revised Feb. 2012]. [Accessed 25 Jan. 2019] (online) Available from:External Link
  4. Donepezil. Hatfield, Hertfordshire: Eisai Ltd.; 1997 [revised 11 May 2018]. [Accessed 25 Jan. 2019] (online) Available from:External Link
  5. Donepezil hydrochloride. South Ruislip, UK: Aurobindo Pharma - Milpharm Ltd.; 2013 [revised 23 Nov. 2017] [Accessed 19 Jun. 2019] (online) Available from:External Link
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed 22 Mar. 2019] (online) Available from:External Link

Manufacturer/Marketer Address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Country of Origin: India

Expires on or after: August, 2022

A licensed vendor partner from your nearest location will deliver Donep 10 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
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