Desleaf ER 100 Tablet

Reviewed By Dr. Mekhala Chandra, MD, MBBS

Last updated on 21 Sep 2025 | 05:34 PM (IST)

Desleaf ER 100 Tablet is a prescription medicine used in the treatment of depression. This medicine helps by increasing the level of chemical messengers (serotonin and noradrenaline) in the brain that have a calming effect on the brain and relaxes the nerves, thus treating your depression.

Genuine

Authenticity Assured

Prescription

required

₹198 MRP ₹22512% off

Desleaf ER 100 Tablet is currently sold out

Same composition alternative:

MDD XR 100 Tablet

₹585~~₹645.64~~

Available alternative from Abbott

Sold out

Desleaf ER 100 Tablet

strip of 10 tablet er

₹198

~~₹225~~

Same composition

MDD XR 100 Tablet

strip of 15 tablet er

Desvenlafaxine (100mg)

by Abbott

Get in 30 mins

₹585

₹33.13 per unit

₹497

order for

₹1200

Save more with additional offers

Pay with Amazon Pay Balance and get cashback up to Rs. 100 with minimum cashback of Rs. 20

Earn cashback up to Rs. 100 with Amazon Pay Later

Assured cashback up to ₹300 on minimum payment of ₹300 using Paytm UPI*

Pay with Amazon Pay Balance and get cashback up to Rs. 100 with minimum cashback of Rs. 20

Earn cashback up to Rs. 100 with Amazon Pay Later

Assured cashback up to ₹300 on minimum payment of ₹300 using Paytm UPI*

10% cashback up to 200 on Min Transaction of Rs.1000, for first time users of Airtel Payments Bank.

Get cashback up to ₹500

Get upto Rs.500 Cashback on minimum transaction of Rs.999/- with Mobikwik Wallet.

Get upto Rs.150 Cashback

General Information

Contains

Desvenlafaxine (100mg)

Marketer

Adivis Pharma Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Desleaf ER 100 Tablet is taken by mouth with or without food. Take it at a fixed time each day to maintain consistent level of medicine in the blood. In case you have missed a dose, take it as soon as you remember. Do not skip any doses and finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to doctor as this may worsen your symptoms.

Some common side effects of this medicine includes nausea, vomiting, insomnia (difficulty in sleeping), and constipation. It may cause an increase in blood pressure, especially during the first month of treatment, monitor your blood pressure regularly. It may even cause dizziness and sleepiness, do not drive or do anything that requires mental focus until you know how this medicine affects you. It is important to inform your doctor if you develop any unusual changes in mood as it may lead to suicidal thoughts.

Uses of Desleaf Tablet ER

Depression

Benefits of Desleaf Tablet ER

Depression
Depression is a mood disorder that affects emotional well-being, energy, and daily functioning. Desleaf ER 100 Tablet is used to manage depression by helping to restore balance in brain chemicals that influence mood. It supports better emotional stability, reduces symptoms like sadness, and helps improve overall quality of life.

Side effects of Desleaf Tablet ER

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Desleaf

Anxiety
Constipation
Decreased appetite
Dizziness
Increased sweating
Insomnia (difficulty in sleeping)
Nausea
Sexual dysfunction
Vomiting

How to use Desleaf Tablet ER

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Desleaf ER 100 Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Desleaf Tablet ER works

Desleaf ER 100 Tablet works by increasing the levels of chemical messengers (serotonin and noradrenaline), natural substances in the brain that help maintain mental balance.

All substitutes for Desleaf ER 100 Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Desleaf ER 100 Tablet helps in treating depression and anxiety.
It may take 2 to 4 weeks for Desleaf ER 100 Tablet to start working. Keep taking it as prescribed.
It may cause dizziness and sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
Avoid consuming alcohol when taking Desleaf ER 100 Tablet as it may cause excessive drowsiness and increase the risk of liver damage.
It may cause a sensation of restlessness, especially when you first start taking it. Inform your doctor if this happens to you.
Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
Do not stop taking the medication suddenly without talking to your doctor.

Safety advice

Alcohol

CAUTION

Caution is advised when consuming alcohol with Desleaf ER 100 Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Desleaf ER 100 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Desleaf ER 100 Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

UNSAFE

Desleaf ER 100 Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Desleaf ER 100 Tablet should be used with caution in patients with kidney disease. Dose adjustment of Desleaf ER 100 Tablet may be needed. Please consult your doctor.

Liver

CAUTION

Desleaf ER 100 Tablet should be used with caution in patients with liver disease. Dose adjustment of Desleaf ER 100 Tablet may be needed. Please consult your doctor.

Interaction with drugs

Taking Desleaf with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Moclobemide (Oral Route)

Do not consume Moclobemide with Desvenlafaxine. If Moclobemide is essential, ensure a gap of at least 1 week after discontinuing Desvenlafaxine. Please consult your doctor.

Life-threatening

Tranylcypromine (Oral Route)

Your doctor may monitor your potassium levels regularly.

Life-threatening

Selegiline (Oral Route)

Do not consume Selegiline with Desvenlafaxine. If Selegiline is essential, ensure a gap of at least 2 weeks after discontinuing Desvenlafaxine. Please consult your doctor.

Severe

Ziprasidone (Oral Route)

Watch out for symptoms such as tremors, fever, diarrhea or agitation and consult your doctor if you experience them. Your doctor may discontinue the medicines accordingly.

Severe

Amitriptyline (Oral Route)

Talk to your doctor if you notice any unusual symptoms. Your doctor may adjust the dose if required.

Frequently asked questions

How long does it take for Desleaf ER 100 Tablet to work?

The symptoms of depression like change in appetite and sleep patterns may show improvement within 1-2 weeks of starting Desleaf ER 100 Tablet. However, it may take about 5-6 weeks to see the full benefits of Desleaf ER 100 Tablet.

Is Desleaf ER 100 Tablet good for anxiety?

It has been shown to be effective in relieving symptoms of anxiety, though it is not approved for anxiety. It is used in anxiety disorders only when advised by the doctor.

What time of the day is best to take Desleaf ER 100 Tablet?

Desleaf ER 100 Tablet can be taken either in the morning or in the evening. For best results, take this medicine at the same time each day. This will also help you remember to take it.

Can Desleaf ER 100 Tablet be cut?

Desleaf ER 100 Tablet should be swallowed whole with water. It should not be cut, chewed, crushed or dissolved. Take it exactly as directed by your doctor.

How can Desleaf ER 100 Tablet help treat depression?

Desleaf ER 100 Tablet belongs to a class of medicines known as serotonin and norepinephrine reuptake inhibitors (SNRIs). Serotonin and norepinephrine are chemical messengers in the brain which help maintain mental balance. Desleaf ER 100 Tablet works by increasing the levels of these two hormones in the brain.

Will I gain weight while taking Desleaf ER 100 Tablet?

Weight gain may occur with Desleaf ER 100 Tablet, though not in everyone. In case you notice weight gain after taking Desleaf ER 100 Tablet, consult your doctor or a nutritionist. Take a low calorie food, including more vegetables and fruits in your diet and exercise regularly.

Will Desleaf ER 100 Tablet affect my sex drive?

Taking Desleaf ER 100 Tablet may cause a decrease in sexual desire and ability. It may also cause a delay in orgasm and ejaculation and sometimes ejaculation failure. Discuss with your doctor if you experience any of these symptoms while taking Desleaf ER 100 Tablet.

Fact Box

Chemical Class

Cyclohexanols Derivative

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)

References

Stahl SM, editor. Desvenlafaxine. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 175-80.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 375-77.
Central Drugs Standard Control Organisation (CDSCO). [Accessed 22 Mar. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Desvenlafaxine. [Updated 2018 Oct 31]. [Accessed 20 Feb. 2020] (online) Available from:
Desvenlafaxine [Prescribing Information]. Philadelphia, PA: Wyeth Pharmaceuticals LLC; 2021. [Accessed 19 Jun. 2023]. (online) Available from:
Desvenlafaxine Extended Release [Product Information Sheet]. Ahmedabad, Gujarat: Torrent Pharmaceuticals Ltd. 2014. [Accessed 20 Feb. 2024] (online) Available from: torrentian.com/pisheet/Upload/PI_Sheet/1536.pdf

Want to know more

We provide you with authentic, trustworthy and relevant information

Have issue with the content

Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Manufacturer details

Name: Pure & Cure Healthcare Pvt. Ltd. (A subsidiary of Akums Drugs & Pharmaceuticals Ltd.)
Address: Plot No. 26A, 27-30, Sector-8A, I.I.E., SIDCUL, Ranipur, Haridwar-249 403, Uttarakhand/Vill. Manakpur, P.O. Lodhimajra, Baddi-173 205, Distt.-Solan, (H.P.)

Marketer details

Name: Adivis Pharma Pvt Ltd
Address: P NO-19-WZ-5-A-1,Vishnu Garden, West Delhi, Delhi,India-110018

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Desleaf ER 100 Tablet

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Desleaf Tablet ER

Benefits of Desleaf Tablet ER

Side effects of Desleaf Tablet ER

How to use Desleaf Tablet ER

How Desleaf Tablet ER works

All substitutes for Desleaf ER 100 Tablet

D-Veniz 100 Tablet ER

Ventab DXT 100 Tablet ER

Nexvenla -OD 100 Tablet ER

Newven OD 100 Tablet ER

Desveren 100 Tablet ER

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Moclobemide (Oral Route)

Tranylcypromine (Oral Route)

Selegiline (Oral Route)

Ziprasidone (Oral Route)

Amitriptyline (Oral Route)

Frequently asked questions

How long does it take for Desleaf ER 100 Tablet to work?

Is Desleaf ER 100 Tablet good for anxiety?

What time of the day is best to take Desleaf ER 100 Tablet?

Can Desleaf ER 100 Tablet be cut?

How can Desleaf ER 100 Tablet help treat depression?

Will I gain weight while taking Desleaf ER 100 Tablet?

Will Desleaf ER 100 Tablet affect my sex drive?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Manufacturer details

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests