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Denlafax 50 Tablet PR

Desvenlafaxine (50mg)

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Denlafax 50 Tablet PR is a prescription medicine used in the treatment of depression. This medicine helps by increasing the level of chemical messengers (serotonin and noradrenaline) in the brain that have a calming effect on the brain and relaxes the nerves, thus treating your depression.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 07 Jan 2026 | 03:32 PM (IST)

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General Information

Contains

Desvenlafaxine (50mg)

Marketer

Emcure Pharmaceuticals Ltd

Storage

Store below 25°C

The content is shown in English

Product introduction

Denlafax 50 Tablet PR is taken by mouth with or without food. Take it at a fixed time each day to maintain consistent level of medicine in the blood. In case you have missed a dose, take it as soon as you remember. Do not skip any doses and finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to doctor as this may worsen your symptoms.

Some common side effects of this medicine includes nausea, vomiting, insomnia (difficulty in sleeping), and constipation. It may cause an increase in blood pressure, especially during the first month of treatment, monitor your blood pressure regularly. It may even cause dizziness and sleepiness, do not drive or do anything that requires mental focus until you know how this medicine affects you. It is important to inform your doctor if you develop any unusual changes in mood as it may lead to suicidal thoughts.

Uses of Denlafax Tablet PR

Depression

Benefits of Denlafax Tablet PR

Depression
Depression is a mood disorder that affects emotional well-being, energy, and daily functioning. Denlafax 50 Tablet PR is used to manage depression by helping to restore balance in brain chemicals that influence mood. It supports better emotional stability, reduces symptoms like sadness, and helps improve overall quality of life.

Side effects of Denlafax Tablet PR

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Denlafax

Anxiety
Constipation
Decreased appetite
Dizziness
Increased sweating
Insomnia (difficulty in sleeping)
Nausea
Sexual dysfunction
Vomiting

How to use Denlafax Tablet PR

Use it as advised by your doctor or check the label for directions before use. Denlafax 50 Tablet PR may be taken with or without food.

How Denlafax Tablet PR works

Denlafax 50 Tablet PR works by increasing the levels of chemical messengers (serotonin and noradrenaline), natural substances in the brain that help maintain mental balance.

Quick tips

Denlafax 50 Tablet PR helps in treating depression and anxiety.
It may take 2 to 4 weeks for Denlafax 50 Tablet PR to start working. Keep taking it as prescribed.
It may cause dizziness and sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
Avoid consuming alcohol when taking Denlafax 50 Tablet PR as it may cause excessive drowsiness and increase the risk of liver damage.
It may cause a sensation of restlessness, especially when you first start taking it. Inform your doctor if this happens to you.
Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
Do not stop taking the medication suddenly without talking to your doctor.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Denlafax 50 Tablet PR. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Denlafax 50 Tablet PR is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CAUTION

Denlafax 50 Tablet PR should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.

Driving

CONSULT YOUR DOCTOR

It is not known whether Denlafax 50 Tablet PR alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

CAUTION

Denlafax 50 Tablet PR should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Denlafax 50 Tablet PR should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Denlafax with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Moclobemide (Oral Route)

Do not consume Moclobemide with Desvenlafaxine. If Moclobemide is essential, ensure a gap of at least 1 week after discontinuing Desvenlafaxine. Please consult your doctor.

Life-threatening

Tranylcypromine (Oral Route)

Your doctor may monitor your potassium levels regularly.

Life-threatening

Selegiline (Oral Route)

Do not consume Selegiline with Desvenlafaxine. If Selegiline is essential, ensure a gap of at least 2 weeks after discontinuing Desvenlafaxine. Please consult your doctor.

Severe

Ziprasidone (Oral Route)

Watch out for symptoms such as tremors, fever, diarrhea or agitation and consult your doctor if you experience them. Your doctor may discontinue the medicines accordingly.

Severe

Amitriptyline (Oral Route)

Talk to your doctor if you notice any unusual symptoms. Your doctor may adjust the dose if required.

Frequently asked questions

How long does it take for Denlafax 50 Tablet PR to work?

The symptoms of depression like change in appetite and sleep patterns may show improvement within 1-2 weeks of starting Denlafax 50 Tablet PR. However, it may take about 5-6 weeks to see the full benefits of Denlafax 50 Tablet PR.

Is Denlafax 50 Tablet PR good for anxiety?

It has been shown to be effective in relieving symptoms of anxiety, though it is not approved for anxiety. It is used in anxiety disorders only when advised by the doctor.

What time of the day is best to take Denlafax 50 Tablet PR?

Denlafax 50 Tablet PR can be taken either in the morning or in the evening. For best results, take this medicine at the same time each day. This will also help you remember to take it.

Can Denlafax 50 Tablet PR be cut?

Denlafax 50 Tablet PR should be swallowed whole with water. It should not be cut, chewed, crushed or dissolved. Take it exactly as directed by your doctor.

How can Denlafax 50 Tablet PR help treat depression?

Denlafax 50 Tablet PR belongs to a class of medicines known as serotonin and norepinephrine reuptake inhibitors (SNRIs). Serotonin and norepinephrine are chemical messengers in the brain which help maintain mental balance. Denlafax 50 Tablet PR works by increasing the levels of these two hormones in the brain.

Will I gain weight while taking Denlafax 50 Tablet PR?

Weight gain may occur with Denlafax 50 Tablet PR, though not in everyone. In case you notice weight gain after taking Denlafax 50 Tablet PR, consult your doctor or a nutritionist. Take a low calorie food, including more vegetables and fruits in your diet and exercise regularly.

Will Denlafax 50 Tablet PR affect my sex drive?

Taking Denlafax 50 Tablet PR may cause a decrease in sexual desire and ability. It may also cause a delay in orgasm and ejaculation and sometimes ejaculation failure. Discuss with your doctor if you experience any of these symptoms while taking Denlafax 50 Tablet PR.

Fact Box

Chemical Class

Cyclohexanols

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)

References

Stahl SM, editor. Desvenlafaxine. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 175-80.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 375-77.
Central Drugs Standard Control Organisation (CDSCO). [Accessed 22 Mar. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Desvenlafaxine. [Updated 2018 Oct 31]. [Accessed 20 Feb. 2020] (online) Available from:
Desvenlafaxine [Prescribing Information]. Philadelphia, PA: Wyeth Pharmaceuticals LLC; 2021. [Accessed 19 Jun. 2023]. (online) Available from:
Desvenlafaxine Extended Release [Product Information Sheet]. Ahmedabad, Gujarat: Torrent Pharmaceuticals Ltd. 2014. [Accessed 20 Feb. 2024] (online) Available from: torrentian.com/pisheet/Upload/PI_Sheet/1536.pdf

User feedback

Patients taking Denlafax 50 Tablet PR

Once A Day

88%

Twice A Day

10%

Alternate Day

What are you using Denlafax Tablet PR for?

Depression

91%

Diabetic nerve pain

How much was the improvement?

Excellent

58%

Average

25%

Poor

17%

What were the side-effects while using Denlafax 50 Tablet PR?

No Side Effect

50%

Decreased appetite

50%

How do you take Denlafax Tablet PR?

With or without food

50%

With food

50%

Please rate Denlafax 50 Tablet PR on price

Average

33%

Not Expensive

33%

Expensive

33%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Emcure Pharmaceuticals Ltd
Address: 255/2, Hinjawadi, Pune - 411057, India / Godown A, Gat No. 408 and 410, Vill: Urse, Tal: Maval, Pune-410 506, Maharashtra, India.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Denlafax 50 Tablet PR. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

Why we need a prescription?

Home

Neuro Cns

Anti Depressants And Mood Stabilisers

Denlafax 50 Tablet PR

Denlafax 50 Tablet PR

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Free Return

Expiry after

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Denlafax Tablet PR

Benefits of Denlafax Tablet PR

Side effects of Denlafax Tablet PR

How to use Denlafax Tablet PR

How Denlafax Tablet PR works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Moclobemide (Oral Route)

Tranylcypromine (Oral Route)

Selegiline (Oral Route)

Ziprasidone (Oral Route)

Amitriptyline (Oral Route)

Frequently asked questions

How long does it take for Denlafax 50 Tablet PR to work?

Is Denlafax 50 Tablet PR good for anxiety?

What time of the day is best to take Denlafax 50 Tablet PR?

Can Denlafax 50 Tablet PR be cut?

How can Denlafax 50 Tablet PR help treat depression?

Will I gain weight while taking Denlafax 50 Tablet PR?

Will Denlafax 50 Tablet PR affect my sex drive?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

User feedback

Patients taking Denlafax 50 Tablet PR

What are you using Denlafax Tablet PR for?

How much was the improvement?

What were the side-effects while using Denlafax 50 Tablet PR?

How do you take Denlafax Tablet PR?

Please rate Denlafax 50 Tablet PR on price

Want to know more

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Disclaimer

Marketer details

Vendor Details

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