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Clitrip 25mg Tablet

Written By Dr. Sakshi Jain, MS, BDS
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS
Last updated on 21 Sep 2025 | 06:03 PM (IST)
Clitrip 25mg Tablet is a tricyclic antidepressant that is used to treat depression and nighttime bedwetting (nocturnal enuresis). Additionally, it may also be prescribed for neuropathic pain.
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Clitrip 25mg Tablet image
Clitrip 25mg Tablet image

Product introduction

Clitrip 25mg Tablet works by increasing the levels of chemical messengers in the brain that stabilizes and enhances the mood. It is better to take it before bedtime because it can make you feel drowsy. It can be taken with or without food, but you should take it at a fixed time each day for better efficacy. The dose and duration will be decided by your doctor so that you get the right amount to control your symptoms. 

The most common side effects of this medicine include increased heart rate, blurred vision, dryness in the mouth, difficulty in urination, and constipation. Initially, this medicine may also cause a sudden drop in blood pressure when you change positions. It may even cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. To lower the chance of dizziness, rise slowly if you have been sitting or lying down. It may also lead to weight gain in some people. Most of the common side effects tend to be mild and temporary. Your doctor may be able to suggest ways of preventing or reducing side effects if they bother you or do not go away. Serious side effects associated with this medicine are rare.

Before taking this medicine, it is important to tell your doctor if you are taking or have recently taken any other medicines for the same or any other diseases. Pregnant and breastfeeding women should take this medicine with proper consultation and caution. This medicine is not known to be addictive, but you can experience additional side effects (withdrawal symptoms) if you stop taking it suddenly. If you notice any sudden mood change or get suicidal or self-harm thoughts, you must consult the doctor without delay. Also, remember to take this medicine strictly as advised by the doctor as an overdose of this medication may lead to a serious health emergency. Consumption of alcohol should be avoided as alcohol interacts with this medicine to cause serious health issues.

Uses of Clitrip Tablet

Benefits of Clitrip Tablet

Bed-wetting
Bed-wetting in children or adults can be distressing and affect sleep and confidence. Clitrip 25mg Tablet helps by reducing bladder overactivity at night, leading to fewer episodes of bed-wetting and improved sleep quality.
Depression
Depression is a condition marked by persistent sadness, loss of interest, and low energy that disrupts daily life. Clitrip 25mg Tablet helps lift mood, restore interest in activities, and improve overall emotional balance, supporting better mental health and well-being.
Neuropathic pain
Neuropathic pain is caused by nerve damage and may feel like burning, tingling, or shooting pain, often disturbing daily life. Clitrip 25mg Tablet reduces this nerve-related pain, improving comfort and allowing for better sleep and daily functioning.

Side effects of Clitrip Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Clitrip
  • Decreased libido
  • Tremors
  • Confusion
  • Fatigue
  • Dilatation of pupil
  • Nausea
  • Agitation
  • Constipation
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)
  • Weight gain
  • Taste change
  • Paresthesia (tingling or pricking sensation)
  • Loss of accommodation
  • Palpitations
  • Atrioventricular block
  • Nasal congestion (stuffy nose)
  • Dryness in mouth
  • Abnormal ECG
  • Headache
  • Abnormality of voluntary movements
  • Erectile dysfunction

How to use Clitrip Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Clitrip 25mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Clitrip Tablet works

Clitrip 25mg Tablet is a tricyclic antidepressant. It increases the levels of chemical messengers in the brain that help in regulating the mood and treat depression.

Quick tips

  • Clitrip 25mg Tablet is used for the treatment of depression and bedwetting in children.
  • The main dose should be taken at night as this drug may cause drowsiness or sleepiness.
  • You may be asked for regular blood tests to monitor the blood cell count or level of sodium and sugar in the blood.
  • Inform your doctor if you notice behavioral changes, mood changes and suicidal thoughts while taking this medicine. 
  • Do not drive or do anything that requires concentration until you know how the medicine affects you.
  • Do not stop taking the medication suddenly without talking to your doctor.
  • The main dose should be taken at night as this medicine may produce drowsiness or sleepiness.
  • It can take 2 to 3 weeks for Clitrip 25mg Tablet to start working.
  • You should continue the treatment for at least 6 months after you feel better to stop depression from coming back.
  • If your doctor asks you to stop Clitrip 25mg Tablet, you should reduce the dose slowly over 4 weeks. You should not discontinue it abruptly.
  • Avoid driving or operating machinery as it may decrease alertness.
  • Avoid consuming alcohol when taking the Clitrip 25mg Tablet, as it may cause excessive drowsiness and calmness.
  • The addiction/dependence potential of Clitrip 25mg Tablet is very less.
  • It may be extremely dangerous in overdose. 

Safety advice

Alcohol

Alcohol

UNSAFE
Clitrip 25mg Tablet may cause excessive drowsiness with alcohol.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Clitrip 25mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Clitrip 25mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving

Driving

UNSAFE
Clitrip 25mg Tablet may cause side effects which could affect your ability to drive.
As Clitrip 25mg Tablet may affect your alertness which may affect your ability to drive.
Kidney

Kidney

CAUTION
Clitrip 25mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Clitrip 25mg Tablet may be needed. Please consult your doctor.
Liver

Liver

CAUTION
Clitrip 25mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Clitrip 25mg Tablet may be needed. Please consult your doctor.
Inform your doctor if you develop any signs and symptoms of jaundice while taking this medicine. Use of Clitrip 25mg Tablet is not recommended in patients with severe liver disease.

Interaction with drugs

Taking Clitrip with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Life-threatening

Moclobemide (Oral Route)

Do not consume Moclobemide with Nortriptyline. If Moclobemide is essential, ensure a gap of at least 1 day after discontinuing Nortriptyline. Please consult your doctor.
Life-threatening

Domperidone (Oral Route)

Do not consume Domperidone with Nortriptyline.
Life-threatening

Tranylcypromine (Oral Route)

Do not consume Tranylcypromine with Nortriptyline. If Tranylcypromine is essential, ensure a gap of at least 2 weeks after discontinuing Nortriptyline. Please consult your doctor.
Severe

Tramadol (Injection Route)

Careful consideration is advised if you have epilepsy. Watch out for symptoms of serotonin syndrome, such as sedation, respiratory impairment, tremors, fever, diarrhea, or agitation, and consult your doctor if you experience them. Your doctor may alter or discontinue the medicines accordingly.
Severe

Thioridazine (Oral Route)

If concurrent use is essential, watch out for symptoms such as sleepiness, dry mouth, impaired voluntary movements, weight gain, constipation, muscle stiffness or tremors and consult your doctor if you experience them. Factors such as old age, chronic heart issues, or low potassium levels may more frequently cause disturbance in heart rhythm, and your doctor may consider ECG monitoring in their presence.

Frequently asked questions

Clitrip 25mg Tablet is used to treat depression and nocturnal (night time) bedwetting in children. It restores the chemical imbalance in the brain and enhances mood and behavior. In some cases, it may also be prescribed to relieve neuropathic (nerve) pain.
Yes, Clitrip 25mg Tablet can be taken for nerve pain. Your doctor may prescribe this medicine in combination with gabapentin. Nerve pain (or neuropathic pain) is commonly described as a shooting, burning or stabbing type of pain that may be associated with tingling, numbness or a pin and needles like feeling. The pain may be spontaneous which means it may be triggered without the presence of any stimulating factor. Additionally, you may experience an increase in the sensitivity to touch. Consult your doctor if you experience such pain.
The side effects of Clitrip 25mg Tablet are increased heart rate, weight gain, difficulty in urination, orthostatic hypotension (sudden decrease in blood pressure on standing), dryness in mouth and constipation. Please consult your doctor if these side effects do not go away or worry you.
Clitrip 25mg Tablet and amitriptyline belong to the same category of medicines with similar action, but their effect may vary upon individual response.
Clitrip 25mg Tablet is safe if used in the dose and duration advised by your doctor. Take it exactly as directed and do not skip any dose. Follow your doctor's instructions carefully and let your doctor know if any of the side effects bother you.
No, you must not stop taking Clitrip 25mg Tablet suddenly even if you are feeling better as it may worsen your condition. It may also cause withdrawal symptoms such as dizziness, nausea, vomiting, headache, weakness, sleep problems, fever and irritability. Continue taking Clitrip 25mg Tablet for the duration prescribed by your doctor to get maximum benefit. If any of the side effects are bothering you, consult your doctor. In case you have completed your course of treatment, your doctor will reduce your dose gradually before taking you off this medicine completely.
Clitrip 25mg Tablet may cause drowsiness and dizziness, especially in the beginning of the treatment. Do not drive or work with tools or machinery if your alertness is affected. It is not advisable to drink alcohol during treatment with this medicine as it might worsen the drowsiness. Tell your doctor if you have any problems with your liver or kidneys. Let your doctor know about all the other medicines you are taking because they may affect, or be affected by, this medicine. Inform your doctor if you are pregnant, planning to conceive or breastfeeding to prevent any harmful effects on the baby.
Yes, Clitrip 25mg Tablet can cause urinary problems. It is more commonly seen in elderly people who are above 65 years of age. The person may face difficulty in passing urine which can further lead to a urinary tract infection. You should consult your doctor immediately if you develop these symptoms.
An overdose of Clitrip 25mg Tablet can be significantly dangerous. In case of an overdose, you may experience symptoms such as blurred vision, fast or irregular heartbeats, dry mouth and tongue, fits and fever. You may also experience agitation (anxiety), confusion, hallucinations, uncontrolled movements, low blood pressure, difficulty breathing, discoloration of the skin (turning blue), drowsiness, loss of consciousness, or you may even go into a state of coma. Immediately consult your doctor and seek medical help if you have taken more than the recommended amount of Clitrip 25mg Tablet.
If you have missed a dose of Clitrip 25mg Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next scheduled dose. Do not double the dose to make up for the missed one as this may increase the chances of developing side effects.
Before taking Clitrip 25mg Tablet, you should tell your doctor if you are allergic to Clitrip 25mg Tablet or any of its ingredients to avoid any allergic reactions. Inform your doctor if you have any problems with your heart, liver, thyroid, prostate or kidneys. Tell your doctor if you have or ever had epilepsy (seizures or fits), diabetes, or glaucoma. Let your doctor know about all the other medicines you are taking because they may affect, or be affected by, this medicine. Also, inform your doctor if you are pregnant, planning to conceive or breastfeeding to prevent any harmful effects on the baby.
Yes, Clitrip 25mg Tablet is effective if taken in the dose and duration prescribed by the doctor. Do not consume more than the recommended dose and avoid skipping doses. Inform your doctor if you experience any side effects while taking Clitrip 25mg Tablet to know about ways to manage or prevent them. It may take a few weeks for you to see improvement in your symptoms. However, the treatment may be continued for a few months for effective management of your condition.

Fact Box

Chemical Class

Dibenzocycloheptene Derivative

Habit Forming

No

Therapeutic Class

NEURO CNS

Action Class

Tricyclic Antidepressants (TCAs)

References

  1. Stahl SM, editor. Nortriptyline. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 477-83.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1006-1007.
  3. Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 25 Mar. 2019] (online) Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Oxford Pharmaceuticals Pvt Ltd
Address: 302, ADITIRAJ ARCADE, NEAR HETVI TOWER, 100 FEET RING ROAD, SATELLITE, AHMEDABAD – 380015.

Vendor Details

Country of origin: India
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