Axentri 150mg Tablet
Prescription Required
Product introduction
Axentri 150mg Tablet belongs to a group of medicines called CCR5 antagonists. It is used to treat HIV (human immunodeficiency virus), the virus that can cause AIDS (acquired immunodeficiency syndrome). It prevents the entry of HIV virus into the human body and thus controls the infection.
Axentri 150mg Tablet is not a cure for HIV or AIDS and only helps to decrease the amount of HIV in your body. This helps to lower your risk of getting HIV-related complications and improves your lifespan. It is prescribed in combination with other HIV medicines. Your doctor will recommend the best medicines for you and will decide the doses that you need. Follow the instructions carefully, for all the medicines that you are given. It may be taken with or without food, preferably at a fixed time. Taking all these medicines regularly at the right times greatly increases their effectiveness and reduces the chances of HIV becoming resistant to them. It is important not to miss doses and to keep taking them until your doctor tells you it is safe to stop.
Some common side effects include nausea, rash, anemia (low red blood cell count), insomnia (difficulty sleeping), weakness and stomach pain. These are usually not serious but tell your doctor if they bother you or persist for a longer duration. Rarely, some people may experience a skin reaction or liver damage. Your doctor will closely monitor you for these in the initial period of treatment.
Before taking it, tell your doctor if you have any skin problems or liver or kidney disease. While using it, you may need regular blood tests to check your blood counts and liver function. Avoid drinking alcohol as it may increase your risk of liver damage. Pregnant or breastfeeding mothers should consult their doctor before using this medicine. Do not have unprotected sex or share personal items like razors or toothbrushes, if you are HIV positive. Talk to your doctor about safe ways like condoms to prevent HIV transmission during sex.
Axentri 150mg Tablet is not a cure for HIV or AIDS and only helps to decrease the amount of HIV in your body. This helps to lower your risk of getting HIV-related complications and improves your lifespan. It is prescribed in combination with other HIV medicines. Your doctor will recommend the best medicines for you and will decide the doses that you need. Follow the instructions carefully, for all the medicines that you are given. It may be taken with or without food, preferably at a fixed time. Taking all these medicines regularly at the right times greatly increases their effectiveness and reduces the chances of HIV becoming resistant to them. It is important not to miss doses and to keep taking them until your doctor tells you it is safe to stop.
Some common side effects include nausea, rash, anemia (low red blood cell count), insomnia (difficulty sleeping), weakness and stomach pain. These are usually not serious but tell your doctor if they bother you or persist for a longer duration. Rarely, some people may experience a skin reaction or liver damage. Your doctor will closely monitor you for these in the initial period of treatment.
Before taking it, tell your doctor if you have any skin problems or liver or kidney disease. While using it, you may need regular blood tests to check your blood counts and liver function. Avoid drinking alcohol as it may increase your risk of liver damage. Pregnant or breastfeeding mothers should consult their doctor before using this medicine. Do not have unprotected sex or share personal items like razors or toothbrushes, if you are HIV positive. Talk to your doctor about safe ways like condoms to prevent HIV transmission during sex.
Uses of Axentri Tablet
Benefits of Axentri Tablet
In HIV infection
Axentri 150mg Tablet prevents HIV from multiplying in the body. It helps control the infection and make the immune system work better. This lowers the chances of getting complications, such as new infections, and improves the quality of life. This medicine is always taken in combination with other antiretroviral medicines.
It is not a cure of HIV or AIDS and should not be used to prevent HIV after accidental exposure to a risk. It is important to take this medicine as prescribed by the doctor. Taking all doses in the right amount at the right times greatly increases the effectiveness of this combination of medicines and reduces the chances of HIV infection becoming resistant to antiretroviral medicines. Although taking this medicine does not prevent the passing of HIV to other people.
It is not a cure of HIV or AIDS and should not be used to prevent HIV after accidental exposure to a risk. It is important to take this medicine as prescribed by the doctor. Taking all doses in the right amount at the right times greatly increases the effectiveness of this combination of medicines and reduces the chances of HIV infection becoming resistant to antiretroviral medicines. Although taking this medicine does not prevent the passing of HIV to other people.
Side effects of Axentri Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Axentri
- Nausea
- Rash
- Anemia (low number of red blood cells)
- Insomnia (difficulty in sleeping)
- Weakness
- Increased liver enzymes
- Abdominal pain
- Flatulence
- Loss of appetite
- Depression
How to use Axentri Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Axentri 150mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
How Axentri Tablet works
Axentri 150mg Tablet is a chemokine receptor antagonist. It shows its action by binding to the human chemokine receptor CCR5 present on the membrane of CD4 cells (T-cells) and prevents the interaction of HIV with CCR5 required by the HIV virus to enter the human cells.
Safety advice
Alcohol
CAUTION
Caution is advised when consuming alcohol with Axentri 150mg Tablet. Please consult your doctor.
Pregnancy
SAFE IF PRESCRIBED
Axentri 150mg Tablet is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Breast feeding
UNSAFE
Axentri 150mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving
CAUTION
Axentri 150mg Tablet may cause dizziness or weakness due to low blood pressure. Do not drive if these symptoms occur.
Kidney
CAUTION
Axentri 150mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Axentri 150mg Tablet may be needed. Please consult your doctor.
Liver
CAUTION
Axentri 150mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Axentri 150mg Tablet may be needed. Please consult your doctor.
What if you forget to take Axentri Tablet?
If you miss a dose of Axentri 150mg Tablet, skip it and continue with your normal schedule. Do not double the dose.\n
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine
Quick tips
- Axentri 150mg Tablet is given to slow the progress of HIV infection.
- Although treatment with Axentri 150mg Tablet can reduce the risk of you passing HIV to others through sexual contact, it does not stop it. It is therefore important to use condoms.
- If you develop any infection soon after taking Axentri 150mg Tablet, inform your doctor. As a result of taking Axentri 150mg Tablet, your immune system may start fighting an infection that was present before you started the treatment, but you might not be aware of it.
- It is common for people with HIV to feel low or even depressed, especially soon after the diagnosis has been made. If you have any feelings of depression it is advisable to speak with your doctor.
Fact Box
Chemical Class
Tropane alkaloids
Habit Forming
No
Therapeutic Class
ANTI INFECTIVES
Action Class
HIV-1 Entry Inhibitor / CCR5 receptor blocker
Interaction with drugs
Taking Axentri with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Bosentan may reduce blood levels of Maraviroc.
Do not consume Maraviroc with Bosentan.
Atazanavir may raise blood levels of Maraviroc.
Do not consume Maraviroc with Atazanavir. If concurrent use is essential, your doctor may monitor your kidney's function along with
Aprepitant may raise blood levels of Maraviroc.
watch out for symptoms of Maraviroc side effects such as nausea, rash, difficulty in sleeping, weakness or headache and consult you
Crizotinib may raise blood levels of Maraviroc.
watch out for symptoms of Maraviroc side effects such as nausea, rash, difficulty in sleeping, weakness or headache and consult you
Mifepristone may raise blood levels of Maraviroc.
watch out for symptoms of Maraviroc side effects such as nausea, rash, difficulty in sleeping, weakness or headache and consult y
Patient concerns
User feedback
What are you using Axentri Tablet for?
HIV infection
100%
How much was the improvement?
Poor
100%
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Flexner C. Antiretroviral Agents and Treatment of HIV Infection. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. pp. 1656-57.
- Safrin S. Antiviral Agents. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 866.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 837-39.
- Maraviroc [FDA Label]. New York, New York: Pfizer Labs; 2007. [Accessed 01 Apr. 2019] (online) Available from:
- Maraviroc [Package Leaflet]. Zaventem, Belgium: Pfizer Service Company; 2018. [Accessed 01 Nov. 2019] (online) Available from:
- Medscape. Maraviroc. [Accessed 01 Apr. 2019] (online) Available from:
Marketer details
Name: Emcure Pharmaceuticals Ltd
Address: 255/2, Hinjawadi, Pune - 411057, India
Country of origin: India
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