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Bosentan

INFORMATION

Uses

Bosentan is used in the treatment of pulmonary hypertension (high pressure in the blood vessels of lungs).

How it works

Bosentan relaxes blood vessels of the lungs which lowers their blood pressure.

Common side effects

Abnormal liver function tests, Anemia, Decreased blood pressure, Diarrhoea, Fainting, Headache, Hypersensitivity reaction, Indigestion, Ankle swelling, Fluid retention, Limb swelling, Flushing, Skin redness, Tachycardia, Heart rate irregular

AVAILABLE MEDICINE

Expert advice

  • Bosentan controls the symptoms of pulmonary arterial hypertension but does not cure it. It may take 1-2 months or longer before you experience the full benefit of bosentan.
  • Do not stop taking bosentan suddenly even if you feel well as this may worsen your symptoms.
  • You may have to undergo regular blood test every month during the treatment to check for anemia (low hemoglobin) and liver function.
  • Do not drive or operate any tools or machines while using bosentan, as it may cause dizziness affecting your ability to drive and use machines.
  • While taking bosentan, women must use a highly effective form of birth control or two methods together (example, contraceptive pills plus barrier method) to prevent pregnancy during treatment.

Frequently asked questions

Bosentan

Q.What is bosentan used for/ what is bosentan therapy?
Bosentan is used in adults and children to treat high blood pressure in the vessels that carry blood to the lungs (pulmonary arterial hypertension). It is also used in adults for the treatment of painful and difficult to heal open sores on fingers and toes (digital ulcers)

Q.Does bosentan work?
Bosentan is effective if taken at recommended dosage and duration as advised by your doctor

Q.Is bosentan an orphan drug?
Yes, bosentan is an orphan drug

Q.Is bosentan cytotoxic?
Bosentan is not a cytotoxic drug. However, studies have shown that bosentan induces liver injury by accumulation of cytotoxic bile salts

Q.Is bosentan available in India?
Yes, it is available in India.


Content on this page was last updated on 24 November, 2016, by Dr. Varun Gupta (MD Pharmacology)