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Aprifast IV Injection

Fosaprepitant (150mg)
Genuine
Authenticity Assured
Prescription
required
Cold stored
Stored between 2-8°C
Aprifast IV Injection is a prescription medicine used to prevent nausea and vomiting caused by chemotherapy.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 17 Aug 2026 | 01:02 AM (IST)
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Expiry after

Nov, 2026

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General Information

Contains

Fosaprepitant (150mg)

Marketer

Axiommax Oncology Pvt Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.
The content is shown in English
Aprifast IV Injection image
Aprifast IV Injection image

Product introduction

Aprifast IV Injection is given under the supervision of healthcare professional. Moreover, it is better to take it at a fixed time and you should not stop taking this medication suddenly without talking to your doctor. In case you have missed a dose than it is better to take it as soon as you remember it and finish the full course of treatment even if you feel better. Your doctor may advice for regular monitoring of liver function test while taking this medicine.

It has side effects like fatigue, headache, loss of appetite, constipation and hiccups. Dizziness and sleepiness may also occur as a side effect, so do not drive or do anything that requires mental focus until you know how this medicine affects you.

Uses of Aprifast Injection

  • Nausea and vomiting due to chemotherapy

Benefits of Aprifast Injection

Nausea and vomiting due to chemotherapy
Chemotherapy-induced nausea and vomiting a distressing side effects experienced by cancer patients undergoing treatment. It can lead to dehydration, poor nutrition, and reduced quality of life, often interfering with the continuation of therapy. Aprifast IV Injection helps prevent these symptoms by blocking neurokinin and effectively reducing both the immediate and delayed phases of nausea and vomiting. It improves patient comfort, supports better adherence to chemotherapy, and enhances overall treatment outcomes.

Side effects of Aprifast Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Aprifast
  • Indigestion
  • Fatigue
  • Weakness
  • Diarrhea
  • Decreased white blood cell count (neutrophils)
  • Anemia (low number of red blood cells)
  • Peripheral neuropathy (tingling and numbness of feet and hand)
  • Decreased white blood cell count (lymphocytes)
  • Urinary tract infection
  • Pain in extremity

How to use Aprifast Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Aprifast Injection works

Aprifast IV Injection is an antiemetic medication. It works by blocking the action of a chemical messenger (neurokinin) in the brain that may cause nausea and vomiting during anti-cancer treatment (chemotherapy).

All substitutes for Aprifast IV Injection

For information purposes only. Consult a doctor before taking any medicine.

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ES Pitant 150mg Injection

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Apregen 150mg Injection

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Amitant-IV Injection

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Quick tips

  • Aprifast IV Injection is given as a drip into the vein under the supervision of a doctor.
  • It makes you feel dizzy or drowsy. Do not drive until you know how this medicine affects you.
  • You will be monitored for liver functioning regularly while taking this medication.
  • Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Aprifast IV Injection. Please consult your doctor.
Pregnancy

Pregnancy

SAFE IF PRESCRIBED
Aprifast IV Injection is generally considered safe to use during pregnancy. Animal studies do not indicate harmful effects. However, there are limited human studies.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Aprifast IV Injection during breastfeeding is not available. Please consult your doctor.
Driving

Driving

UNSAFE
Aprifast IV Injection may cause side effects that could affect your ability to drive.
Kidney

Kidney

CAUTION
Aprifast IV Injection should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver

Liver

CONSULT YOUR DOCTOR
There is limited data available on the use of Aprifast IV Injection in patients with liver disease.
No dose adjustment is recommended in patients with moderate to severe liver disease.
All

Interaction with drugs

Taking Aprifast with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Apalutamide (Oral Route)

Concomitant use should be avoided. Please consult with your doctor. Apalutamide may increase the metabolism of Fosaprepitant.
Moderate

Gliclazide (Oral Route)

Monitor your blood sugar levels regularly. Fosaprepitant may reduce blood levels of Gliclazide.
Moderate

Diltiazem (Oral Route)

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.
Moderate

Trabectedin (Injection Route)

If concurrent use is essential, watch out for symptoms such as nausea, vomiting, impaired movements, rash, diarrhea, dizziness, or drowsiness, and consult your doctor if you experience them. Fosaprepitant may raise blood levels of Trabectedin.
Moderate

Allylestrenol (Oral Route)

It is recommended to use barrier methods (like condoms), IUDs, or a depot for contraception. Your doctor may monitor your treatment closely and adjust the doses as per the observations. Use barrier methods (like condoms) for contraception to reduce the risk of HIV infection. Fosaprepitant may reduce blood levels of Allylestrenol.

Frequently asked questions

Aprifast IV Injection is used to help prevent nausea and vomiting that may be caused by cancer chemotherapy. These symptoms can occur during treatment or even several days after treatment and can affect nutrition, hydration, and overall comfort. Aprifast IV Injection can help prevent chemotherapy-induced nausea and vomiting, making cancer treatment more manageable and improving quality of life during therapy.
Aprifast IV Injection contains Fosaprepitant, a medicine used to prevent nausea and vomiting. It works by blocking the effect of a natural substance in the brain called substance P. Substance P is involved in triggering nausea and vomiting. Fosaprepitant blocks these signals to help prevent both the immediate nausea that can occur shortly after chemotherapy and the delayed nausea that can occur over the following days.
Yes. Aprifast IV Injection is specifically used to help prevent both acute and delayed nausea and vomiting caused by chemotherapy. Symptoms may develop several days after treatment and can be difficult to control. The prolonged action of Aprifast IV Injection helps reduce the likelihood of these symptoms occurring after chemotherapy.
No. Aprifast IV Injection is primarily used to prevent nausea and vomiting related to chemotherapy. It is not generally used for motion sickness, routine stomach upset, or other common causes of nausea unless specifically recommended by your doctor for a particular medical reason.
Aprifast IV Injection is usually administered by a doctor as part of an anti-nausea treatment plan before chemotherapy begins. The timing depends on the specific chemotherapy regimen and your doctor's recommendations. It is generally given before treatment starts to help prevent symptoms from developing.
No. Aprifast IV Injection is an injection that should only be administered by a doctor in a hospital, clinic, or healthcare setting. Self-administration is not recommended because proper preparation, dosing, and monitoring are important for safe and effective treatment.
Yes. Some medicines, including certain diabetes medicines such as Glimepiride and Gliclazide, may interact with Aprifast IV Injection. Inform your doctor about all medicines you are taking before treatment. Your doctor may monitor you more closely or make treatment adjustments if necessary.
Yes. Aprifast IV Injection may interact with certain heart medicines, including Diltiazem. Before receiving treatment, tell your doctor about all prescription medicines, over-the-counter products, and supplements you use. This helps identify and manage any potential interactions appropriately.
Seek immediate medical attention if you develop difficulty breathing, wheezing, swelling of the face, lips, tongue, or throat, severe itching, a widespread rash, or sudden dizziness after receiving Aprifast IV Injection. These symptoms may indicate a serious allergic reaction that requires urgent treatment.
Aprifast IV Injection is designed to provide protection against chemotherapy-related nausea and vomiting beyond the day of treatment. Its effects can help cover both the immediate period after chemotherapy and the delayed phase when nausea and vomiting may still occur, providing extended symptom prevention.

Fact Box

Chemical Class

Phenylmorpholines

Habit Forming

No

Therapeutic Class

GASTRO INTESTINAL

Action Class

Neurokinin-1 (NK1) Receptor Antagonists

References

  1. McQuaid KR. Drugs Used in the Treatment of Gastrointestinal Diseases. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 1086.
  2. Fosaprepitant dimeglumine. Hoddesdon, Hertfordshire: Merck Sharp & Dohme Limited; 2008 [revised 29 Nov. 2018]. [Accessed 29 Jan. 2019] (online) Availale from:
  3. Fosaprepitant. Highway, Greenville, NC: DSM Pharmaceuticals; 2008. [Accessed 28 Mar. 2019] (online) Available from:
  4. Central Drugs Standard Control Organisation (CDSCO). [Accessed 28 Mar. 2019] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Axiommax Oncology Pvt Ltd
Address: A/303, Atrium -1, Andheri - Kurla Road, Mumbai – 400 059 India

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Aprifast IV Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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