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Trabectedin is used for the treatment of advanced soft tissue sarcoma and ovarian cancer in combination with other chemotherapy drugs. 

How it works

Trabectedin belongs to class of drugs called alkylating agents. It works by sticking to the DNA in cells and damaging it. This stops the cancer cells growing and multiplying.

Common side effects

Nausea, Anemia, Constipation, Decreased blood cell count, Diarrhoea, Shortness of breath, Fatigue, Headache, Liver toxicity, Loss of appetite, Soreness, Swelling, Fluid retention, Vomiting


Expert advice

• Seek immediate medical attention if you develop a fever, muscle pain or weakness, as trabectedin may cause side effects affecting your blood, liver or muscles.
• Use effective contraception while on trabectedin therapy.
• Do not consume alcohol while taking trabectedin as it may worsen the side effects.
• Should not be given to patients allergic to trabectedin or any of its ingredients.
• Should not be given to children below 18 years.
• Should not be given to pregnant and breastfeeding women.

Frequently asked questions


Q. Is trabectedin FDA approved?
Yes, trabectedin is FDA approved.

Content on this page was last updated on 03 October, 2016, by Dr. Varun Gupta (MD Pharmacology)