Aplevant 1.5mg Pre-filled Pen (0.5ml Each)
Prescription Required
Product introduction
Aplevant 1.5mg Pre-filled Pen (0.5ml Each) is an injectable medicine used to lower blood glucose levels in adults with type 2 diabetes. It works by helping your body produce insulin and reducing the amount of sugar your liver makes.
The dose of Aplevant 1.5mg Pre-filled Pen (0.5ml Each) will depend on your condition and what other diabetes medicines you are taking. You can use it at any time of day with or without food but try to use it on the same day each week to get the most benefit. Your doctor or nurse will show you how and where to inject the medicine. Follow the instructions carefully. Do not stop taking this medicine without talking to your doctor. If you do, your blood glucose levels may increase and put you at risk of serious complications. It should be used with a proper diet and exercise to control high blood glucose. Aplevant 1.5mg Pre-filled Pen (0.5ml Each) should be stored in a fridge until you need it but do not freeze it.
The most common side effects of Aplevant 1.5mg Pre-filled Pen (0.5ml Each) include nausea, diarrhea, abdominal pain, and loss of appetite. It can also lead to hypoglycemia (low blood sugar level) especially if you are taking other medicines to lower blood sugar. Make sure you know how to recognize and deal with it.
Before using this medicine, talk to your doctor if you have ever had liver or kidney disease, pancreatitis, or stomach problems. Also, tell your doctor if you are taking any other medicines which may affect the way this medicine works. If you are pregnant or breastfeeding, ask your doctor if it is safe to take Aplevant 1.5mg Pre-filled Pen (0.5ml Each).
The dose of Aplevant 1.5mg Pre-filled Pen (0.5ml Each) will depend on your condition and what other diabetes medicines you are taking. You can use it at any time of day with or without food but try to use it on the same day each week to get the most benefit. Your doctor or nurse will show you how and where to inject the medicine. Follow the instructions carefully. Do not stop taking this medicine without talking to your doctor. If you do, your blood glucose levels may increase and put you at risk of serious complications. It should be used with a proper diet and exercise to control high blood glucose. Aplevant 1.5mg Pre-filled Pen (0.5ml Each) should be stored in a fridge until you need it but do not freeze it.
The most common side effects of Aplevant 1.5mg Pre-filled Pen (0.5ml Each) include nausea, diarrhea, abdominal pain, and loss of appetite. It can also lead to hypoglycemia (low blood sugar level) especially if you are taking other medicines to lower blood sugar. Make sure you know how to recognize and deal with it.
Before using this medicine, talk to your doctor if you have ever had liver or kidney disease, pancreatitis, or stomach problems. Also, tell your doctor if you are taking any other medicines which may affect the way this medicine works. If you are pregnant or breastfeeding, ask your doctor if it is safe to take Aplevant 1.5mg Pre-filled Pen (0.5ml Each).
Uses of Aplevant Solution for Injection
Side effects of Aplevant Solution for Injection
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Aplevant
- Nausea
- Diarrhea
- Vomiting
- Abdominal pain
- Loss of appetite
How to use Aplevant Solution for Injection
Your doctor or nurse will guide you how to use this medicine.
How Aplevant Solution for Injection works
Aplevant 1.5mg Pre-filled Pen (0.5ml Each) is an anti-diabetic medication. It works by increasing the release of insulin from the pancreas, decreases hormones that raise blood sugar levels, slows down digestion, and reduces appetite.
Safety advice
Alcohol
UNSAFE
It is unsafe to consume alcohol with Aplevant 1.5mg Pre-filled Pen (0.5ml Each).
Pregnancy
CONSULT YOUR DOCTOR
Aplevant 1.5mg Pre-filled Pen (0.5ml Each) may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Information regarding the use of Aplevant 1.5mg Pre-filled Pen (0.5ml Each) during breastfeeding is not available. Please consult your doctor.
Driving
CONSULT YOUR DOCTOR
It is not known whether Aplevant 1.5mg Pre-filled Pen (0.5ml Each) alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Kidney
SAFE IF PRESCRIBED
Aplevant 1.5mg Pre-filled Pen (0.5ml Each) is safe to use in patients with kidney disease. No dose adjustment of Aplevant 1.5mg Pre-filled Pen (0.5ml Each) is recommended.
However, monitor renal function in patients with renal impairment reporting severe adverse gastrointestinal reactions. Use Aplevant 1.5mg Pre-filled Pen (0.5ml Each) with caution in patients with ESRD.
However, monitor renal function in patients with renal impairment reporting severe adverse gastrointestinal reactions. Use Aplevant 1.5mg Pre-filled Pen (0.5ml Each) with caution in patients with ESRD.
Liver
SAFE IF PRESCRIBED
Aplevant 1.5mg Pre-filled Pen (0.5ml Each) is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Aplevant 1.5mg Pre-filled Pen (0.5ml Each) may not be needed in these patients. Please consult your doctor.
What if you forget to take Aplevant Solution for Injection?
If you miss a dose of Aplevant 1.5mg Pre-filled Pen (0.5ml Each), take it as soon as you remember. If the next dose is to be taken within the next 72 hours, skip the missed dose. Do not take 2 doses of Aplevant 1.5mg Pre-filled Pen (0.5ml Each) within 72 hours of each other.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine
Quick tips
- You can inject Aplevant 1.5mg Pre-filled Pen (0.5ml Each) into the same body area each week, but try not to use the exact same spot.
- Store the pen in the refrigerator. When refrigeration is not possible, you can also keep your pen at room temperature (less than 30°C) for up to 2 weeks. Do not freeze it.
- Do not use Aplevant 1.5mg Pre-filled Pen (0.5ml Each) if particles appear or if the solution is cloudy and/or discolored.
- Aplevant 1.5mg Pre-filled Pen (0.5ml Each) may cause nausea, vomiting, diarrhea, or stomach pain, which may get better with time. Eat smaller meals, limit fatty food intake and inform your doctor if it does not go away.
Fact Box
Chemical Class
Glucagon-like Peptide-1 (GLP-1) Analogue
Habit Forming
No
Therapeutic Class
ANTI DIABETIC
Action Class
Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists
Interaction with drugs
Taking Aplevant with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Concurrent use may increase the risk of low blood sugar levels. Elderly, malnourished, diabetic individuals and those with kidney and heart dysfunction are at higher risk.
If conc
Concurrent use may interfere with control over blood sugar.
Your doctor may monitor your diabetic control closely and adjust the doses as per the observations.
Concurrent use may interfere with control over blood sugar.
Your doctor may monitor your diabetic control closely and adjust the doses as per the observations.
Concurrent use may increase the risk of high blood sugar levels. Budesonide may reduce the efficacy of Dulaglutide.
If concurrent use is essential, your doctor may monitor your tre
Concurrent use may increase the risk of low blood sugar levels.
Monitor your blood glucose levels regularly and talk to your doctor if you notice any abnormal or unexpected change
Patient concerns
User feedback
What are you using Aplevant Solution for Injection for?
Type 2 diabet*
100%
*Type 2 diabetes mellitus
FAQs
When is the best time to take Aplevant 1.5mg Pre-filled Pen (0.5ml Each)?
Aplevant 1.5mg Pre-filled Pen (0.5ml Each) is to be taken only once a week at any time of the day with or without food. Consult your doctor for more advice.
How is Aplevant 1.5mg Pre-filled Pen (0.5ml Each) administered?
Aplevant 1.5mg Pre-filled Pen (0.5ml Each) is injected under the skin (subcutaneously) of your stomach, thigh, or upper arm. It should not be injected into a muscle or vein. You can use the same area of your body each week to take the injection, but make sure that a different injection site is used within that area. Use Aplevant 1.5mg Pre-filled Pen (0.5ml Each) as advised by your doctor. You can take it with or without food. If you are on insulin as well, do not mix insulin and Aplevant 1.5mg Pre-filled Pen (0.5ml Each) in the same syringe. It is also recommended to check your blood sugar levels regularly.
How does Aplevant 1.5mg Pre-filled Pen (0.5ml Each) work for weight loss?
Aplevant 1.5mg Pre-filled Pen (0.5ml Each) is used in type 2 diabetes mellitus. It improves blood sugar control and slows down digestion. This brings a feeling of fullness and satiety due to which the food intake by the patient decreases. As a result, the patient eats less which further helps in weight loss.
Is Aplevant 1.5mg Pre-filled Pen (0.5ml Each) an insulin?
No, Aplevant 1.5mg Pre-filled Pen (0.5ml Each) is not an insulin. It is a medicine used to lower blood sugar (glucose) levels in adults with type 2 diabetes mellitus. In type 2 diabetes insulin is deficient, and the insulin that your body produces does not work as well as it should. Aplevant 1.5mg Pre-filled Pen (0.5ml Each) acts on the pancreas to increase insulin release, suppress glucagon secretion, and decrease glucose production from the liver. It also slows down the emptying of the stomach.
Can you take Aplevant 1.5mg Pre-filled Pen (0.5ml Each) and insulin together?
Yes, your doctor may prescribe you this medicine with insulin if adequate glucose management is not obtained after using Aplevant 1.5mg Pre-filled Pen (0.5ml Each) with other antidiabetic medicines. Insulin is often used early in the treatment of individuals with complications or symptoms of extremely high blood glucose levels. If insulin is used together with Aplevant 1.5mg Pre-filled Pen (0.5ml Each), there is often greater efficacy of both medications and improved treatment outcomes. <br>
Can Aplevant 1.5mg Pre-filled Pen (0.5ml Each) be used to treat type 1 diabetes?
No, Aplevant 1.5mg Pre-filled Pen (0.5ml Each) should not be used in patients with type 1 diabetes mellitus or for the treatment of patients with diabetic ketoacidosis.
Can Aplevant 1.5mg Pre-filled Pen (0.5ml Each) cause pancreatitis?
There are reports of acute pancreatitis due to Aplevant 1.5mg Pre-filled Pen (0.5ml Each). Patients are prompted to discontinue this medicine and contact their doctor if there is persistent severe abdominal pain, sometimes radiating to the back.<br>
Is regular self-monitoring of blood sugar required while taking Aplevant 1.5mg Pre-filled Pen (0.5ml Each)?
Regular self-monitoring of blood sugar is not needed in order to adjust the dose of Aplevant 1.5mg Pre-filled Pen (0.5ml Each). However, when initiating treatment with Aplevant 1.5mg Pre-filled Pen (0.5ml Each) in combination with other anti-diabetic medicines, monitoring of blood sugar may become necessary to reduce the dose of the anti-diabetic medicine in order to lower the risk of hypoglycemia. <br>
What should I avoid while taking Aplevant 1.5mg Pre-filled Pen (0.5ml Each)?
Avoid fried or fatty foods and foods high in sugar while taking Aplevant 1.5mg Pre-filled Pen (0.5ml Each) to reduce the risk of nausea and vomiting. Eat slowly, and eat smaller meals that are light and bland.
How to store Aplevant 1.5mg Pre-filled Pen (0.5ml Each)?
Aplevant 1.5mg Pre-filled Pen (0.5ml Each) should be refrigerated at 2°C - 8°C, but do not freeze it. Store Aplevant 1.5mg Pre-filled Pen (0.5ml Each) in the original packaging to protect from light. Keep the medicine out of the reach of children. Do not use the medicine if you notice that the pen is damaged or the medicine has become cloudy/discolored or has lumps in it.
Are there any potential risks of using Aplevant 1.5mg Pre-filled Pen (0.5ml Each)?
Apart from the usual side effects of the medicine, Aplevant 1.5mg Pre-filled Pen (0.5ml Each) has been found to cause Medullary Thyroid Carcinoma, a type of cancer of the thyroid gland. Its use may also increase the risk of inflammation of the pancreas commonly known as pancreatitis which is a serious and painful condition. Discontinue the medicine and contact your doctor immediately if you suspect any signs or symptoms of thyroid problems (lump in throat, hoarseness, and difficulty in speaking) or pancreatitis (stomach ache radiating to the back, upper abdominal pain, fever, nausea, and vomiting).
What is the significance of HbA1c test?
Your doctor may ask you to get your HbA1c tested every 3 months. This test is done to see how well you have managed your blood sugar for the past 2-3 months.
Can Aplevant 1.5mg Pre-filled Pen (0.5ml Each) be used with other diabetes medicine?
Yes, Aplevant 1.5mg Pre-filled Pen (0.5ml Each) can be used alone or in combination with other diabetes medicines only if prescribed by your doctor.
Can I take a protein-rich diet along with Aplevant 1.5mg Pre-filled Pen (0.5ml Each)?
Yes, you can take a diet rich in protein along with Aplevant 1.5mg Pre-filled Pen (0.5ml Each). Proteins are one of the major energy providers among all essential nutrients. Besides, being the building blocks of the human body, proteins break down into glucose to release energy. Unlike carbohydrates, the metabolism of proteins into glucose is much slower. Therefore, the release of energy usually takes a few hours after consumption. Thus, the spike in blood sugar levels might occur after a few hours when you are on a high-protein diet. It is often recommended to consume about 2-3 teaspoons of proteins in the evening snacks to avert the chances of hypoglycemia.<br><br>
Can I take artificial sweeteners while taking Aplevant 1.5mg Pre-filled Pen (0.5ml Each)?
No, artificial sweeteners are not good for people with diabetes. They are composed of chemicals that can cause mild to severe side effects. Thus, it is better to limit or avoid their use as much as you can.<br>
Can diabetes cause kidney failure?
Yes, uncontrolled diabetes can cause kidney failure. In the long run, diabetes can affect the kidneys leading to a condition called diabetic nephropathy. Diabetic nephropathy is a condition that is a major cause of kidney failure in patients with diabetes. The best way to prevent damage to kidneys is by keeping diabetes in check, making dietary changes, monitoring sugar levels regularly, getting routine blood tests done, and taking prescribed medications on time.<br>
Can diabetes be cured?
Diabetes is a condition that causes changes in your blood glucose levels, which if left uncontrolled, can lead to serious health complications affecting the heart, brain, kidneys, and eyes. However, with simple lifestyle changes, diet, and medications, one can manage their condition and lead a healthy life.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Dulaglutide. Indianapolis, Indiana: Eli Lilly and Company; 2014 [revised Jan. 2017]. [Accessed 25 Jan. 2019] (online) Available from:
- Dulaglutide [Prescribing Information]. Indianapolis, IN: Eli Lilly and Company; 2021. [Accessed 22 Jan 2021] (online) Available from:
- DailyMed. Dulaglutide [Prescription Drug Label]. [Accessed 28 Sept. 2021] (online) Available from:
- Dulaglutide [Product Monograph]. Ontario, Canada: Eli Lilly Canada Inc.; 2021. [Accessed 22 Jan. 2021] (online) Available from:
- Dulaglutide [Prescribing Information]. Indianapolis, IN: Eli Lilly and Company; 2022. [Accessed 20 June 2023]. (online) Available from:
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