Agotine 25mg Tablet

Prescription Required
Store at room temperature (10-30°C)


Agotine 25mg Tablet helps treat depression. It reduces and gradually eliminates the symptoms of depression such as deep sadness, feelings of worthlessness, loss of interest in activities, sleep disturbances, tiredness, feelings of anxiety, and weight changes.

Agotine 25mg Tablet may be taken with or without food preferably at bedtime. However, it is advised to take it at a fixed time each day to maintain a consistent level of medicine in the blood. If you have missed any doses, take it as soon as you remember and finish the full course of treatment even if you feel better. Do not stop taking it suddenly without talking to your doctor as it may worsen your symptoms.

Some common side effects of this medicine include headache, nausea, fatigue, anxiety, insomnia (difficulty sleeping), and back pain. Other side effects that may also be observed are stomach pain, changes in body weight, diarrhea, and increased liver enzymes. However, these are temporary and usually resolve on their own in some time. Please consult your doctor if these do not subside or worry you. It even causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you.

Before taking this medicine, please tell your doctor if you suffer from any liver problems or diabetes. If you have been taking this medicine for a long time, regular monitoring of blood and liver functions may be required. Be vigilant about unusual darkening or any changes in the color of your urine, light-colored stools, yellowing of skin or eyes, pain in the upper right part of your stomach, and unusual fatigue as this could be signs of liver problems.

It is important to inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts. Pregnant and breastfeeding mothers should consult their doctor before taking this medicine.

Uses of Agotine Tablet

Benefits of Agotine Tablet

In Depression

Agotine 25mg Tablet helps in maintaining the balance of certain chemicals in the brain that affect mood and behavior. It helps you sleep better and increases your energy levels. This improves your mood, relieves anxiety, tension, prevents extreme changes in mood and helps you feel less agitated. You may experience fewer episodes of depression and low mood.
It can take several weeks for this medicine to work and you may still feel low during this time. It is likely that you will take this medicine for at least six months but possibly much longer. It needs to be taken regularly to work effectively. Do not stop taking it unless your doctor tells you to.

Side effects of Agotine Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Agotine

  • Headache
  • Nausea
  • Dizziness
  • Fatigue
  • Anxiety
  • Insomnia (difficulty in sleeping)
  • Back pain
  • Abdominal pain
  • Change in body weight
  • Diarrhea
  • Constipation
  • Sleepiness
  • Increased liver enzymes

How to use Agotine Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Agotine 25mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Agotine Tablet works

Agotine 25mg Tablet is a melatonin agonist. It works by resynchronizing the sleep-wake cycle that is disturbed in depression.

Safety Advice

Caution is advised when consuming alcohol with Agotine 25mg Tablet. Please consult your doctor.
Agotine 25mg Tablet is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Information regarding the use of Agotine 25mg Tablet during breastfeeding is not available. Please consult your doctor.
Agotine 25mg Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Agotine 25mg Tablet is safe to use in patients with kidney disease. No dose adjustment of Agotine 25mg Tablet is recommended.
However, talk to your doctor if you have any underlying kidney disease.
Agotine 25mg Tablet is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.

What if you forget to take Agotine Tablet?

If you miss a dose of Agotine 25mg Tablet, skip it and continue with your normal schedule. Do not double the dose.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
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Quick Tips

  • You have been prescribed Agotine 25mg Tablet for the treatment of depression.
  • It may take a few weeks for this medicine to start working. Keep taking it as prescribed.
  • It should be taken at bedtime.
  • Use caution while driving or doing anything that requires concentration as Agotine 25mg Tablet can cause dizziness and sleepiness.
  • Avoid consuming alcohol while taking this medicine as that may lead to increased side effects.
  • You may need regular blood tests to monitor your liver and kidney functions while you are taking this medication.
  • Inform your doctor if you notice sudden mood changes or develop suicidal thoughts.

Fact Box

Chemical Class
Arylethylamine Derivative
Habit Forming
Therapeutic Class

Patient Concerns

Dr. Jyoti Kapoor Madan
Depression is a persistent state of sadness that is the result of interaction between one's inner biological and psychological state and gets triggered of with environmental stressors. Reactive depression is in response to a situation like loss, sickness, trauma etc. Endogenous depression occurs without any noticeable environmental stressors. Psychological symptoms include lack of interest, negative thinking, irritability, frustration, feeling demotivated etc. Somatic symptoms like fatigue/ weakness/ lack of sleep/ lack of appetite and other physical symptoms are common. Anxiety is common. In severe cases one may feel helpless and hopeless enough to wish for death or attempt suicide. Treatment includes physical and psychiatric work up following which medicines can be prescribed. In milder cases, psychotherapy or counselling is recommended.
Depression,anexity,body. Laziness Depression anxiety,f ear,body laziness
Dr. Ankur Kumar Tanwar
Ok since how many months you are suffer from
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1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.


  1. Stahl SM, editor. Agomelatine. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 5-8.
  2. Agomelatine. Stoke Poges, Slough: Servier Laboratories Limited; 2009 [revised 12 Dec. 2018]. [Accessed 23 Jan. 2019] (online) Available from:External Link
  3. Agomelatine. Les Laboratoires Servier Industrie. [Accesed 19 Mar. 2019]. (online) Available from:External Link
  4. Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:External Link

Manufacturer/Marketer Address

Off. Ashram Road, Ahmedabad - 380 009., Gujarat, India
We do not facilitate sale of this product at present


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