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Agomelatine is used in the treatment of depression

How it works

Agomelatine works by a resynchronizing sleep-wake cycle that is disturbed in depression.

Common side effects

Headache, Nausea, Dizziness, Fatigue, Anxiety, Insomnia (difficulty in sleeping), Back pain, Abdominal pain, Change in body weight, Diarrhoea, Constipation, Sleepiness, Increased liver enzymes

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Expert advice

  • Consult your doctor if you are taking medicines known to affect the liver, are obese or overweight, or have diabetes.
  • Consult your doctor before starting treatment if you have experienced periods of abnormally high excitability and emotions (bipolar disorder, mania or hypomania).
  • You may need regular tests to monitor your liver and kidney function.
  • Inform your doctor if you have ever had suicidal thoughts or thoughts of harming yourself.
  • Caution has to be taken before you drive or operate machinery or engage in activities requiring mental alertness and coordination as agomelatine can cause dizziness and sleepiness.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.
  • Do not drink alcohol while receiving agomelatine treatment as it may worsen the side effects.

Frequently asked questions


Q. Is agomelatine an SSRI?
No, agomelatine belongs to class of medication called as melatonergic antidepressants
Q. Is agomelatine an addictive drug?
No, please follow your doctor's advice regarding its use
Q. Does agomelatine cause weight gain?
Yes, it may cause an increase or decrease in weight.

Content on this page was last updated on 15 March, 2017, by Dr. Varun Gupta (MD Pharmacology)