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Agomelatine is used in adults for the treatment of depression.

How it works

Agomelatine belongs to a class of drugs called melatonergic antidepressants. It binds to the melatonin receptors (MT1 and MT2) to promote their activity and serotonin receptors (5HT2C) to block their activity in brain, thereby improving sleep efficiency, normalizing day-to-day rhythms involved in normal functioning of brain, all of which causes improvement in symptoms of depression.

Common side effects

Vomiting, Nausea, Liver enzyme increased, Anxiety, Back pain, Constipation, Diarrhoea, Dizziness, Fatigue, Headache, Increased sweating, Insomnia, Migraine, Sleepiness, Stomach pain


Expert advice

  • Consult your doctor if you are taking medicines known to affect the liver, are obese or overweight, or have diabetes.
  • Consult your doctor before starting treatment if you have experienced periods of abnormally high excitability and emotions (bipolar disorder, mania or hypomania).
  • You may need regular tests to monitor your liver and kidney function.
  • Inform your doctor if you have ever had suicidal thoughts or thoughts of harming yourself.
  • Caution has to be taken before you drive or operate machinery or engage in activities requiring mental alertness and coordination as agomelatine can cause dizziness and sleepiness.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.
  • Do not drink alcohol while receiving agomelatine treatment as it may worsen the side effects.

Frequently asked questions


Q. Is agomelatine an SSRI?
No, agomelatine belongs to class of medication called as melatonergic antidepressants.
Q. Is agomelatine an addictive drug?
No, please follow your doctor's advice regarding its use.
Q. Does agomelatine cause weight gain?
Yes, it may cause an increase or decrease in weight.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)