
Acosev 400mg Tablet
Written By Dr. Subita Alagh, BDS
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS
Last updated on 19 Jan 2026 | 11:11 AM (IST)
Acosev 400mg Tablet is used to treat increased phosphate levels in the blood. It is used in patients who are on dialysis due to severe kidney disease. It inhibits the absorption of phosphate from the intestine and lowers the phosphate levels in the blood.
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General Information
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Product introduction
Acosev 400mg Tablet should be taken with food. Take it in the dose and duration as advised by your doctor. Take it regularly and at a fixed time each day to get the maximum benefit of the medicine.
Acosev 400mg Tablet may cause side effects such as nausea, vomiting, abdominal pain, constipation, and diarrhea. You may also develop low levels of calcium, folic acid, and vitamins A, D, E, and K in your blood. Take necessary supplements as advised by your doctor.
Uses of Acosev Tablet
Benefits of Acosev Tablet
High phosphate levels in blood
Acosev 400mg Tablet is used to manage high phosphate levels in the blood, especially in people with chronic kidney disease on dialysis. It helps control phosphate buildup, which supports healthy bones and prevents problems like bone pain, itching, and complications related to the heart and blood vessels.
Acosev 400mg Tablet is used to manage high phosphate levels in the blood, especially in people with chronic kidney disease on dialysis. It helps control phosphate buildup, which supports healthy bones and prevents problems like bone pain, itching, and complications related to the heart and blood vessels.
Side effects of Acosev Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Acosev
- Abdominal pain
- Diarrhea
- Flatulence
- Nausea
- Vomiting
- Constipation
How to use Acosev Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Acosev 400mg Tablet should be taken with or after food.
How Acosev Tablet works
Acosev 400mg Tablet inhibits the absorption of phosphate from the intestine and lower the phosphate levels in the blood.
All substitutes for Acosev 400mg Tablet
For information purposes only. Consult a doctor before taking any medicine.
Revlamer 400 Tablet
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₹10.8/tablet
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Acutrol C 400 Tablet
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Acutrol 400 Tablet
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₹20.87/tablet
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Phoscut 400 Tablet
by Steadfast Medishield Pvt Ltd
₹9.08/tablet
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Quick tips
- Acosev 400mg Tablet is used to control blood phosphate level in patients that are on dialysis treatment.
- You must take it with food and stick to the diet prescribed by your doctor.
- You may develop low levels of calcium, folic acid, and vitamins A,D,E, and K in your blood. Your doctor may prescribe supplements, if necessary.
- Avoid taking any other medicine 1 hour before or 3 hours after taking Acosev 400mg Tablet.
- Inform your doctor if you have nausea, vomiting, constipation, pain in the abdomen, or if you have undergone any major stomach surgery.
Safety advice

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Acosev 400mg Tablet. Please consult your doctor.

Pregnancy
CONSULT YOUR DOCTOR
Acosev 400mg Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding
CONSULT YOUR DOCTOR
Acosev 400mg Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving
SAFE
Acosev 400mg Tablet does not usually affect your ability to drive.

Kidney
CONSULT YOUR DOCTOR
There is limited data available on the use of Acosev 400mg Tablet in patients with kidney disease. Please consult your doctor.

Liver
SAFE IF PRESCRIBED
Acosev 400mg Tablet is probably safe to use in patients with liver disease. Limited data suggest dose adjustment may not be needed.
Interaction with drugs
Taking Acosev with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Moderate
Ofloxacin (Oral Route)
To take Ofloxacin, ensure a gap of at least 1 hour before and 3 hours after taking Sevelamer. Sevelamer may reduce blood levels of Ofloxacin.
Moderate
Sparfloxacin (Oral Route)
To take Sparfloxacin, ensure a gap of at least 1 hour before and 3 hours after taking Sevelamer. Sevelamer may reduce blood levels of Sparfloxacin.
Moderate
Norfloxacin (Oral Route)
To take Norfloxacin, ensure a gap of at least 1 hour before and 3 hours after taking Sevelamer. Sevelamer may reduce blood levels of Norfloxacin.
Moderate
Levofloxacin (Oral Route)
To take Levofloxacin, ensure a gap of at least 1 hour before and 3 hours after taking Sevelamer. Sevelamer may reduce blood levels of Levofloxacin.
Moderate
Ciprofloxacin (Oral Route)
To take Ciprofloxacin, ensure a gap of at least 1 hour before and 6 hours after taking Sevelamer. Sevelamer may reduce blood levels of Ciprofloxacin.
Frequently asked questions
Yes, Acosev 400mg Tablet can be taken with food. It is recommended to take 1-2 tablets (based on individual needs) thrice daily. It is important to take it with meals because Acosev 400mg Tablet works by binding to phosphate from food. Take it exactly as advised by your doctor.
No, you should not crush, chew, or break Acosev 400mg Tablet into pieces. You should swallow it as a whole with water.
It is important to take Acosev 400mg Tablet as patients undergoing dialysis cannot control the phosphate levels in their blood, especially after a meal. When the level of phosphate exceeds above the range in the blood, it may cause problems such as itchy skin, red eyes, high blood pressure, bone pain, and also increase the risk of fractures. These increased serum phosphate levels are reduced by Acosev 400mg Tablet, as it binds phosphate from food in the digestive tract.
A common side effect of Acosev 400mg Tablet is constipation, though it does not occur in everyone. The other common side effects of the stomach and intestine include diarrhea, indigestion, flatulence, and pain in the abdomen. Immediately consult your doctor if these side effects become severe and disturb you.
Patients who are allergic to Acosev 400mg Tablet and who have low levels of phosphate in blood should avoid taking Acosev 400mg Tablet. Additionally, patients having intestinal obstruction should also avoid using Acosev 400mg Tablet.
Ciprofloxacin may interfere with the working of Acosev 400mg Tablet and therefore it should not be taken at the same time as Acosev 400mg Tablet. However, if taken together then a gap of at least 2 hours before or 6 hours after taking Acosev 400mg Tablet should be maintained.
Continue taking Acosev 400mg Tablet as long as recommended by your doctor. Acosev 400mg Tablet lowers your dietary phosphate levels but does not cure your disease. Hence, you may have to take it lifelong, as stopping Acosev 400mg Tablet may increase your phosphate levels.
Yes, serum phosphate levels should be monitored regularly while you are taking Acosev 400mg Tablet. Also, the use of Acosev 400mg Tablet may decrease the levels of vitamin D, A, E, K, and folic acid and hence the levels need to be monitored during the treatment.
Fact Box
Chemical Class
Epoxides
Habit Forming
No
Therapeutic Class
BLOOD RELATED
Action Class
Phosphorus Binders
Related lab tests
References
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 1259.
- Sevelamer hydrochloride. Guildford, Surrey: SANOFI; 2000 [revised 20 Dec. 2018]. [Accessed 30 Jan. 2019] (online) Available from:
- Sevelamer. Cambridge, USA: Genzyme Corporation; 1998. [Accessed 6 Apr. 2019] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 6 Apr. 2019] (online) Available from:
- Sevelamer Carbonate [Product Information]. Ahmedabad, Gujarat: La Renon. [Accessed 06 Aug. 2023]. (online) Available from:
- National Center for Biotechnology Information. PubChem Compound Summary for , Sevelamer. [Accessed 06 Aug. 2023]. (online) Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
Marketer details
Name: Accord Pharmaceuticals
Address: 9B, 1st Floor, Chanayak Complex, Opp Murlidhar Society, Odhav, Ahmedabad.
Address: 9B, 1st Floor, Chanayak Complex, Opp Murlidhar Society, Odhav, Ahmedabad.
Vendor Details
Country of origin: India
Lab tests offered by us
- CBC (Complete Blood Count)
- FBS (Fasting Blood Sugar)
- Thyroid Profile Total (T3, T4 & TSH)
- HbA1c (Glycosylated Hemoglobin)
- PPBS (Postprandial Blood Sugar)
- Lipid Profile
- Vitamin D (25-Hydroxy)
- Urine R/M (Urine Routine & Microscopy)
- Coronavirus Covid -19 test- RT PCR
- LFT (Liver Function Test)
- KFT (Kidney Function Test)
- TSH (Thyroid Stimulating Hormone) Ultrasensitive
- ESR (Erythrocyte Sedimentation Rate)
- Uric Acid, Serum
- Vitamin B12
- CRP (C-Reactive Protein), Quantitative
- Urine C/S (Urine Culture and Sensitivity)
- Serum Electrolytes
- Serum Calcium
- Serum Creatinine
- Diabetes Screening (HbA1C & Fasting Sugar)
- KFT with Electrolytes (Kidney Function Test with Electrolytes)
- Cholesterol - Total
- Hb (Hemoglobin)
- Complete Hemogram (CBC & ESR)
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