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Xamdex 100mcg Injection

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Product introduction

Xamdex 100mcg Injection is a prescription medicine used to provide sedation (a state of calm, drowsiness, or sleep) for adult patients in intensive care settings. It may also be used for awake sedation during diagnostic and surgical procedures.

Xamdex 100mcg Injection is given as an infusion (drip) into a vein under the supervision of a healthcare professional. It is important to inform your doctor if you are suffering from any medical conditions like slow heart rate, low blood pressure, neurological disorder, severe liver problems, or have ever developed a serious fever after some medicines, especially after taking anesthesia. Your doctor will monitor the cardiac and respiratory state after providing this injection.

Common side effects of this medicine include dryness in the mouth, decreased blood pressure, and slow heart rate. Consult your doctor if these side effects do not improve with time or worsen. They may be able to suggest ways to prevent or reduce the side effects.

Uses of Xamdex Injection

  • Sedative

Benefits of Xamdex Injection

In Sedative

Xamdex 100mcg Injection helps to calm the activity of the nerves and helps induce a deep state of sleep called sedation. Therefore this medicine acts as a sedative and is used in intensive care units (ICUs) to provide relief to patients and to keep them stress-free. It can also be used to carry out some diagnostic or minor surgical procedures. It is given as an injection by a doctor or nurse in a hospital setup.

Side effects of Xamdex Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Xamdex

  • Dryness in mouth
  • Decreased blood pressure
  • Slow heart rate

How to use Xamdex Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Xamdex Injection works

Xamdex 100mcg Injection works by modulating the action of certain chemical messengers in the brain that relieves pain and induces sleep.

Safety advice

Xamdex 100mcg Injection may cause excessive drowsiness with alcohol.
Xamdex 100mcg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
Xamdex 100mcg Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Not relevant, as Xamdex 100mcg Injection is intended for use in hospitalised patients.
Xamdex 100mcg Injection is safe to use in patients with kidney disease. No dose adjustment of Xamdex 100mcg Injection is recommended.
Xamdex 100mcg Injection should be used with caution in patients with liver disease. Dose adjustment of Xamdex 100mcg Injection may be needed. Please consult your doctor.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
Xamdex 100mcg Injection
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Quick tips

  • Xamdex 100mcg Injection is given as an infusion into the veins by healthcare professionals only.
  • Your doctor will closely monitor your heart rate, blood pressure, breathing rate and oxygen level during the treatment.
  • Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Fact Box

Chemical Class
Imidazole Derivative
Habit Forming
Therapeutic Class
Action Class
Alpha 2-Adrenoceptor agonists (Anaesthetic)

Patient concerns

For atleast 1 year she was on anti depressant and mild sedative in allopathic .now she is pregnant ,suggest me some medicine that can replace once and for all that allopathic medicines.
Dr. Deepak Kumar Soni
Ayurveda,-500MG/StandardClick this link & order the medicine for your problem
1) not getting sleep 2) in the afternoons drouzy, 3) too mucgh irritation
Dr. Ambrish Dharmadhikari
It seems your sleep wake cycle is disturbed. You can try some home remedy like drinking warm milk, use of sedative spices (nutmeg) available at home. It this doesn't help then you can take help from psychiatrist for medications. - Dr. Ambrish Dharmadhikari Consultant Psychiatrist, Mumbai

User feedback


Q. What is Xamdex 100mcg Injection used for?

Xamdex 100mcg Injection is used to provide sedation (a state of calm, drowsiness, or sleep) for adult patients in intensive care settings (i.e. in initially intubated and mechanically ventilated patients or non-intubated patients prior to and/or during surgical and other procedures).

Q. Is Xamdex 100mcg Injection a controlled substance?

Xamdex 100mcg Injection is a sedative that belongs to a class of drugs called centrally active selective 2A agonists.It is not a controlled drug/substance

Q. Is Xamdex 100mcg Injection approved by FDA?

Yes, Xamdex 100mcg Injection approved by FDA

Q. Does Xamdex 100mcg Injection cause amnesia?

Xamdex 100mcg Injection is given as an infusion (drip) into veins. It may cause pain at the injection site and low heart rate (bradycardia). It does not cause amnesia.

Q. How does Xamdex 100mcg Injection work?

Xamdex 100mcg Injection activates the central 2A receptors which causes sedation and analgesia.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.


  1. Stahl SM, editor. Dextromethorphan. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 181-83.
  2. Patel PM, Patel HH, Roth DM. General Anesthetics and Therapeutic Gases. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 548-49.
  3. Biaggioni I, Robertson D. Adrenoreceptor Agonists & Sympathomimetic Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 140, 145.
  4. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 381-82.
  5. Dexmedetomidine hydrochloride. Lake Forest, Illinois: Hospira, Inc.; 1999 [revised Jun. 2013]. [Accessed 12 Feb. 2019] (online) Available from:External Link
  6. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Dexmedetomidine. [Updated 2018 Dec 3]. [Accessed 20 Feb. 2020] (online) Available from:External Link
  7. Central Drugs Standard Control Organisation (CDSCO). [Accessed 22 Mar. 2019] (online) Available from:External Link

Manufacturer/Marketer address

16th Floor, Godrej BKC, Plot – C, “G” Block, Bandra-Kurla Complex, Bandra (East), Mumbai – 400 051, India
Expires on or after: November, 2022

A licensed vendor partner from your nearest location will deliver Xamdex 100mcg Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
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