Uronase 500000IU Injection

Urokinase (500000IU)

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required

Cold stored

Stored between 2-8°C

Uronase 500000IU Injection is a medicine used to break down harmful blood clots that have formed in the blood vessels. It is used to treat patients who have suffered a recent heart attack. It is also used in treating conditions such as pulmonary embolism and stroke.

Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 18 Jul 2026 | 01:02 AM (IST)

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General Information

Contains

Urokinase (500000IU)

Marketer

United Biotech Pvt Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.

The content is shown in English

Product introduction

Uronase 500000IU Injection is administered under the supervision of a doctor. Your doctor will decide the dose and duration of the medicine for you. The doctor may closely monitor your condition until you become stable.

Use of this medicine may cause nausea, vomiting, injection site bleeding, allergic reaction, and a decrease in blood pressure. It may increase your risk of bleeding also. Your doctor will explain the benefits and risks associated with this medicine before it is administered. You should continue all your other medicines that are advised by the doctor for your long-term treatment even after this injection.

This medicine is used with caution for some people. Thus, you must inform the doctor if you are suffering from any bleeding disorder, kidney, or liver disease. Also, let your doctor know if you are pregnant or breastfeeding and about all the other medications that you are taking regularly.

Uses of Uronase Injection

Benefits of Uronase Injection

Heart attack
Uronase 500000IU Injection is used in heart attacks to dissolve blood clots that block blood flow to the heart. This helps restore circulation quickly, reduce heart damage, and improve survival outcomes.

Pulmonary embolism
In pulmonary embolism, Uronase 500000IU Injection helps break down clots in the lungs, improving oxygen flow and relieving symptoms like chest pain and breathlessness. It supports faster recovery and prevents complications.

Side effects of Uronase Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Uronase

Allergic reaction
Nausea
Vomiting
Injection site bleeding
Decreased blood pressure

How to use Uronase Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Uronase Injection works

Uronase 500000IU Injection works by dissolving the harmful blood clots in the blood vessels. This restores the blood flow to the affected tissue, thereby preventing tissue death and improving outcomes.

Quick tips

It increases your risk of bleeding. Be careful while shaving, cutting fingernails or toenails, using sharp objects or engaging in contact sports (e.g. football, wrestling).
Do not discontinue use without consulting your doctor as this may increase your chances of having another heart attack or stroke.
Uronase 500000IU Injection helps break down blood clots in blood vessels, thereby treating conditions such as heart attack, pulmonary embolism, and stroke.
It should be given as soon as possible (within 12 hours) after the onset of a heart attack.
It is usually given by your nurse or doctor as an infusion (drip) into a vein.
It increases your risk of bleeding. Be careful while shaving, cutting fingernails or toenails, using sharp objects or engaging in contact sports (e.g. football, wrestling).
Do not discontinue use without consulting your doctor as this may increase your chances of having another heart attack or stroke.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Uronase 500000IU Injection. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Uronase 500000IU Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Uronase 500000IU Injection during breastfeeding is not available. Please consult your doctor.

Driving

NOT RELEVANT

Not relevant, as Uronase 500000IU Injection is intended for use in hospitalized patients.

Kidney

CAUTION

Uronase 500000IU Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Use of Uronase 500000IU Injection is not recommended in patients with severe kidney disease.

Liver

UNSAFE

Uronase 500000IU Injection is unsafe to use in patients with liver disease and should be avoided.

Interaction with drugs

Taking Uronase with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Cilostazol (Oral Route)

Inform your doctor if you notice any signs of bleeding (bruising, bleeding gums, blood in stool/vomit/urine).

Severe

Apixaban (Oral Route)

Do not consume Apixaban with Urokinase. If concurrent use is essential, watch out for bleeding and consult your doctor immediately. Urokinase may increase the effect of Apixaban.

Severe

Streptokinase (Injection Route)

Do not consume Streptokinase with Urokinase. If Streptokinase is essential, ensure a gap of At least 5 days between taking Streptokinase and Urokinase. Please consult your doctor. Urokinase may reduce the efficacy of Streptokinase.

Moderate

Ticagrelor (Oral Route)

Talk to your doctor if you notice any unusual symptoms.

Moderate

Rivaroxaban (Oral Route)

Talk to your doctor if you notice any unusual symptoms.

Frequently asked questions

Can the use of Uronase 500000IU Injection increase the risk of bleeding?

Yes, Uronase 500000IU Injection increases the risk of bleeding. Always be careful while doing activities that may cause an injury or bleeding. Tell your doctor immediately if you notice any abnormal bruising or bleeding.

What medicines should I avoid while taking Uronase 500000IU Injection?

Uronase 500000IU Injection can interact with several medicines. Do not take any medicine without talking to your doctor.

Fact Box

Chemical Class

Peptides

Habit Forming

Therapeutic Class

CARDIAC

Action Class

First-Generation Thrombolytics

Related lab tests

Platelet Count

References

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1414-5.
Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: United Biotech Pvt Ltd
Address: FC/B-1 (Extn.), Mohan Co-operative Industrial Estate Mathura Road, New Delhi - 110 044

Vendor Details

Country of origin: India

Lab tests offered by us

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Uronase 500000IU Injection

Uronase 500000IU Injection

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Uronase Injection

Benefits of Uronase Injection

Side effects of Uronase Injection

How to use Uronase Injection

How Uronase Injection works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Cilostazol (Oral Route)

Apixaban (Oral Route)

Streptokinase (Injection Route)

Ticagrelor (Oral Route)

Rivaroxaban (Oral Route)

Frequently asked questions

Can the use of Uronase 500000IU Injection increase the risk of bleeding?

What medicines should I avoid while taking Uronase 500000IU Injection?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Platelet Count

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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