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Urokinase is used in the treatment of heart attack and pulmonary embolism.

How it works

Urokinase works by dissolving the harmful blood clots in the blood vessels. This allows reperfusion of affected tissue, preventing tissue death and improving outcomes.

Common side effects

Allergic reaction, Nausea, Vomiting, Decrease in blood pressure, Injection site bleeding

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Expert advice

  • Special care should be taken while using urokinase if you recently have had bleeding from stomach or intestines, had surgery or had given blood recently, had heart problems, have severe blood vessel in the brain or are above 75 years of age.
  • Inform your doctor if you are taking medication like heparin or other anticoagulants, aspirin, non-steroidal anti-inflammatory agents (NSAIDs), dipyridamole or dextrans.
  • Avoid taking aspirin or ibuprofen to treat a fever after you have received urokinase as it may increase your risk of bleeding.
  • Avoid activities that may increase your risk of bleeding or injury.

Frequently asked questions


Q. What is urokinase made from/ found/ produced?
Urokinase is man-made product developed using a protein that occurs naturally in the kidneys. It is obtained from human neonatal kidney cells grown in tissue culture.

Content on this page was last updated on 09 May, 2017, by Dr. Varun Gupta (MD Pharmacology)