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Urokinase

Written By Dr. Anuj SainiReviewed By Dr. Rajeev Sharma
Last updated 25 Nov 2025 | 09:34 AM (UTC)

Urokinase Uses

Urokinase is used in the treatment of heart attack and pulmonary embolism.

How Urokinase works

Urokinase works by dissolving the harmful blood clots in the blood vessels. This restores the blood flow to the affected tissue, thereby preventing tissue death and improving outcomes.

Common side effects of Urokinase

Nausea, Vomiting, Bleeding, Fever, Hypotension (low blood pressure), Back pain
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Expert advice for Urokinase

  • It increases your risk of bleeding. Be careful while shaving, cutting fingernails or toenails, using sharp objects or engaging in contact sports (e.g. football, wrestling).
  • Do not discontinue use without consulting your doctor as this may increase your chances of having another heart attack or stroke.
  • Urokinase helps break down blood clots in blood vessels, thereby treating conditions such as heart attack, pulmonary embolism, and stroke.
  • It should be given as soon as possible (within 12 hours) after the onset of a heart attack.
  • It is usually given by your nurse or doctor as an infusion (drip) into a vein.
  • It increases your risk of bleeding. Be careful while shaving, cutting fingernails or toenails, using sharp objects or engaging in contact sports (e.g. football, wrestling).
  • Do not discontinue use without consulting your doctor as this may increase your chances of having another heart attack or stroke.

Frequently asked questions for Urokinase

Yes, Urokinase increases the risk of bleeding. Always be careful while doing activities that may cause an injury or bleeding. Tell your doctor immediately if you notice any abnormal bruising or bleeding.
Urokinase can interact with several medicines. Do not take any medicine without talking to your doctor.