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Urokinase is used for dissolving blood clots which may be formed in surgical equipment (cannulas or catheters i.e. tubes used to introduce or withdraw fluids in the body), lungs, deep veins or peripheral arteries (in legs).

How it works

Urokinase belongs to a class of medication called thrombolytic agents. It works by breaking down blood clots.

Common side effects

Liver enzyme increased, Nose bleed, Bleeding from puntured wound, Blood clotting disorder, Blood in urine, Chills, Shivering, Decreased haematocrit level, Fever, Bleeding at the puncture site, Brain haemorrhage, Gastrointestinal bleeding, Stroke, Tearing of artery wall


Expert advice

  • Special care should be taken while using urokinase if you recently have had bleeding from stomach or intestines, had surgery or had given blood recently, had heart problems, have severe blood vessel in the brain or are above 75 years of age.
  • Inform your doctor if you are taking medication like heparin or other anticoagulants, aspirin, non-steroidal anti-inflammatory agents (NSAIDs), dipyridamole or dextrans.
  • Avoid taking aspirin or ibuprofen to treat a fever after you have received urokinase as it may increase your risk of bleeding.
  • Avoid activities that may increase your risk of bleeding or injury.

Frequently asked questions


Q. What is urokinase made from/ found/ produced?
Urokinase is man-made product developed using a protein that occurs naturally in the kidneys. It is obtained from human neonatal kidney cells grown in tissue culture.

Content on this page was last updated on 03 October, 2016, by Dr. Varun Gupta (MD Pharmacology)