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Telyse 40mg Injection

Written By Dr. Lipika Khurana, PGDHHM, BDS
Reviewed By Dr. Rajeev Sharma, MBA, MBBS
Last updated on 07 Apr 2026 | 03:01 PM (IST)
Telyse 40mg Injection belongs to a group of medicines called thrombolytic agents. It is used in the emergency treatment of heart attack. It helps to dissolve blood clots that have formed in the blood vessels of the heart.
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General Information

Contains

Tenecteplase (40mg)

Marketer

Cipla Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.
The content is shown in English
Telyse 40mg Injection image
Telyse 40mg Injection image

Product introduction

Telyse 40mg Injection is an injectable drug, given directly into a vein and it is given by a doctor as soon as possible after the first signs of a heart attack. Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely. You may be given another medicine to stop blood clotting at the same time or after the treatment.

The most common side effect of this medicine is bleeding. It may cause injection site bleeding, nosebleeds, blood in the stool, blood in the urine, or gastrointestinal bleeding. While on treatment with this medicine, you should be careful while shaving, cutting nails, or using sharp objects.

This drug needs to be administered with care by an expert and is not suitable for everyone. There is a long list of situations where you will not be given Telyse 40mg Injection including if you’ve had a head injury or surgery on your brain or spinal cord and any current bleeding anywhere in your body. Your healthcare team will need to know a lot about your medical history before giving you this medicine.

Uses of Telyse Injection

Benefits of Telyse Injection

Heart attack
Telyse 40mg Injection dissolves harmful blood clots that cause heart attack (if they are in the heart). They also dissolve clots that form in other blood vessels. This means that blood can again start to flow freely through your body. This medicine will, therefore, reduce both the damage caused by, and the risk of dying from a heart attack. The sooner the injection is given, the greater are the chances of recovery.

Side effects of Telyse Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Telyse
  • Injection site bleeding
  • Nosebleeds
  • Blood in stool
  • Blood in urine
  • Gastrointestinal bleeding

How to use Telyse Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Telyse Injection works

Telyse 40mg Injection is a thrombolytic medication. It works by dissolving the harmful blood clots in the blood vessels. This restores the blood flow to the affected tissue, thereby preventing tissue death and improving outcomes.

Quick tips

  • Telyse 40mg Injection is used to treat myocardial infarctions (heart attacks) as soon as possible (usually within 12 hours) after the onset of symptoms.
  • It is given as an injection into the vein under the supervision of a doctor.
  • It may increase your risk of bleeding. Inform your doctor immediately if you notice bleeding at the injection site, nose bleed, and blood in urine.
  • Continue with your diet and exercise along with previously prescribed medications for heart attack.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Telyse 40mg Injection. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Telyse 40mg Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CAUTION
Telyse 40mg Injection should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.
Driving

Driving

NOT RELEVANT
Not relevant, as Telyse 40mg Injection is intended for use in hospitalized patients.
Kidney

Kidney

CONSULT YOUR DOCTOR
There is limited data available on the use of Telyse 40mg Injection in patients with kidney disease. Please consult your doctor.
Liver

Liver

SAFE IF PRESCRIBED
Telyse 40mg Injection is probably safe to use in patients with liver disease. Limited data suggest dose adjustment may not be needed.

Interaction with drugs

Taking Telyse with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Cilostazol (Oral Route)

Inform your doctor if you notice any signs of bleeding (bruising, bleeding gums, blood in stool/vomit/urine).
Severe

Apixaban (Oral Route)

Do not consume Apixaban with Tenecteplase. If concurrent use is essential, watch out for bleeding and consult your doctor immediately. Tenecteplase may increase the effect of Apixaban.
Moderate

Ticagrelor (Oral Route)

Talk to your doctor if you notice any unusual symptoms.
Moderate

Rivaroxaban (Oral Route)

Talk to your doctor if you notice any unusual symptoms.
Moderate

Tranexamic Acid (Oral Route)

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Tranexamic Acid may block the action of Tenecteplase.

Frequently asked questions

Telyse 40mg Injection should be administered under the supervision of a trained healthcare professional or a doctor only and should not be self-administered. The dose will depend on the condition you are being treated for and will be decided by your doctor. Follow your doctor’s instructions carefully to get maximum benefit from Telyse 40mg Injection.
Telyse 40mg Injection is safe if used in the dose and duration advised by your doctor. Take it exactly as directed and do not skip any dose. Follow your doctor's instructions carefully and let your doctor know if any of the side effects bother you.
Yes, Telyse 40mg Injection increases the risk of bleeding. Always be careful while doing activities that may cause an injury or bleeding. Tell your doctor immediately if you notice any abnormal bruising or bleeding.
Telyse 40mg Injection can interact with several medicines. If you are already taking Telyse 40mg Injection, do not take any other medicine without talking to your doctor.
Telyse 40mg Injection reduces your risk of developing blood clots in the blood vessels of your leg, lungs, heart and brain. You may not feel any difference after taking Telyse 40mg Injection. This does not mean that the medicine is not working, therefore keep taking this medicine as prescribed.

Fact Box

Chemical Class

Peptides

Habit Forming

No

Therapeutic Class

CARDIAC

Action Class

Plasminogen Activators- Thrombolytics

References

  1. Fox KA, White HD, Gersh BJ, et al. Antithrombotic Agents: Platelete Inhibitors, Acute Anticoagulants, Fibrinolytics, and Chronic Anticoagulants. In: Opie LH, Gersh BJ, editors. Drugs for the Heart. 8th ed. Philadelphia, Pennsylvania: Elsevier Saunders; 2013. pp. 382-84.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 1326.
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Cipla Ltd
Address: Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Telyse 40mg Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
Why we need a prescription?
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Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945
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