Medicine Overview of Stiloz Tablet
Stiloz 100 mg Tablet is used in the treatment of intermittent claudication
. It helps in reducing the symptoms of intermittent claudication like pain, cramping, numbness, or weakness in the legs that occurs on walking.
Side Effects of Stiloz are Headache, Palpitations, Abnormal stool, Diarrhoea, Dizziness, Chest pain, Loss of appetite, Bleeding, Rash.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Stiloz 100 mg Tablet is to be taken empty stomach.
Stiloz 100 mg Tablet widens the blood vessels and decreases the stickiness of the platelets which increases blood flow to the lower limbs.
In Depth Information on Stiloz Tablet
- Take cilostazol tablet 1-2 hours before or after meals. minutes before breakfast and the evening meal.
- Do not drive or use machinery that required you to be alert because you may feel sleepy or dizzy while being treated with cilostazol.
- Do not take cilostazol, if you have congestive heart failure. Cilostazol can make this condition worse.
- It may take up to 12 weeks of using cilostazol before your symptoms improve. For best results, keep using the medication as directed.
- Consult your doctor, if your symptoms do not improve after 4 weeks of treatment.
Stiloz Tablet related warnings
Interaction with alcohol is unknown. Please consult your doctor.
WEIGH RISKS VS BENEFITS
Stiloz 100 mg Tablet may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Stiloz 100 mg Tablet is probably unsafe to use during lactation.
Limited human data suggest that the drug could represent a significant risk to the baby.
Stiloz 100 mg Tablet may make you feel dizzy, sleepy, tired, or decrease alertness. If this happens, do not drive.
Stiloz 100 mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Stiloz 100 mg Tablet may be needed. Please consult your doctor.
Stiloz 100 mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Stiloz 100 mg Tablet may be needed. Please consult your doctor.
Use of Stiloz 100 mg Tablet is not recommended in patients with moderate and severe liver disease as the information available in these patients is limited.
If you miss a dose of Stiloz 100 mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Frequently asked questions about Stiloz Tablet
Q. Is Stiloz useful for treating systemic sclerosis?
Stiloz is used as a maintenance therapy for Raynaud's phenomenon in patients with systemic sclerosis. Raynaud's phenomenon is characterized by spasm of blood vessels of extremities causing pale to blue to red sequence of color changes of fingers mainly after exposure to cold. Stiloz is helpful in this condition because of its vasodilating properties.
Q. Is Stiloz useful for erectile dysfunction?
Stiloz is not used for the treatment of erectile dysfunction. It is a vasodilator and inhibits platelet aggregation. It is used to treat peripheral vascular disease.
Q. Can Stiloz be given in patients with underlying renal function?
Use of Stiloz is contraindicated in patients with severe renal disease because its metabolite levels are increased in these patients and can cause harmful effects. It can be used safely in patients with mild to moderate renal disease.
Q. How is Stiloz useful in treating peripheral vascular disease?
Peripheral vascular disease is associated with intermittent claudication which causes pain, cramping, numbness, or weakness in the legs while walking. This occurs due to blockage of arteries and insufficient blood flow to legs. Stiloz increases blood flow and reduces the symptoms of intermittent claudication by widening the arteries and keeping the blood thin (does not allow platelets to stick together and form clots).
Q. Is it advisable to take Stiloz with clarithromycin?
Clarithromycin can increase the level or effect of Stiloz by blocking its breakdown (inhibits metabolism). The dose of Stiloz may need to be adjusted if you have to take clarithromycin or other similar antibiotics like erythromycin along with.
Q. Is Stiloz useful for percutaneous coronary interventions (coronary stenting)?
Stiloz, when used with aspirin and clopidogrel, was found to be superior compared to aspirin and clopidogrel dual combination in preventing coronary artery restenosis or in-stent thrombosis in patients who underwent percutaneous coronary intervention without increasing the risk of bleeding. However, this is not an approved use and these benefits were seen in some clinical studies.
Q. Is Stiloz useful for the prevention of stroke?
Stiloz can prevent new episodes of stroke without increasing the risk of bleeding in patients who once had an episode of ischaemic stroke. It is also seen to be effective for primary prevention of stroke in patients with peripheral artery disease. However, these are not approved uses and the benefits were seen in some clinical studies.
Q. What is the effect of Stiloz on exercise?
Stiloz decreases the muscle pain or cramps that occur during exercise in patients with intermittent claudication. Stiloz can improve exercise capacity as judged by changes in maximal walking distance and pain-free walking distance.
Q. What are the contraindications to the use of Stiloz?
Stiloz is contraindicated in patients with blood, and clotting disorders, heart failure or active pathologic bleeding like bleeding peptic ulcer and intracranial bleeding and known or suspected hypersensitivity to Stiloz or any of its components.
Q. When to stop Stiloz before surgery or regional anesthesia?
Stiloz should be stopped at least five days before surgery if the antiplatelet effect is not needed during the surgery. Due to reversible antiplatelet action and short half-life (11-13 h) of Stiloz, the risk of surgical bleeding is less and regional anesthesia can be safely administered if it is stopped at least 72 h prior to surgery. However, Stiloz should be stopped only after consulting your doctor and the surgeon.
Q. Can I take Stiloz with sildenafil?
Stiloz can be taken with sildenafil. There are no reported drug interactions or harmful effects when Stiloz is taken along with sildenafil.
Q. Why take Stiloz on an empty stomach?
Stiloz is to be taken 30 minutes before breakfast or evening meal as food increases the absorption of Stiloz causing an increased incidence of side-effects.
Q. Can I take Stiloz with warfarin?
Stiloz, when taken with warfarin, can increase the risk of bleeding. So they should be used very cautiously and a regular monitoring by your doctor is advisable to decrease the risk of bleeding.
Q. Is Stiloz useful for varicose veins?
Stiloz is not useful for the management of varicose veins. These are enlarged tortuous veins mainly of the lower limbs. These are treated with compression stockings, sclerotherapy (injecting some substances for closing these veins) or some surgical procedures.
Q. Is it beneficial to take Stiloz with aspirin?
Stiloz, when taken with aspirin, is seen to improve long-term outcomes in patients undergoing percutaneous coronary angioplasty. However, there can be an increased risk of bleeding as both inhibit platelet aggregation and make blood thin. If you are taking Stiloz with aspirin, you should be monitored very closely by your doctor.
Q. What was the role of Stiloz in restenosis trial?
Stiloz for RESTenosis (CREST) clinical trial aimed to evaluate the efficacy of Stiloz in inhibiting restenosis after stent implantation. The results showed a significant reduction in the occurrence of restenosis with the use of Stiloz over the standard therapy after coronary stenting.
Q. Can I take Stiloz with ticagrelor?
Stiloz and ticagrelor, when used together, can increase the effects of each other by inhibiting clotting of blood and increasing the risk of bleeding. Avoid taking them together or you should be monitored very closely by your doctor.
Q. Is Stiloz useful for the treatment of neuropathy?
Animal studies demonstrate the beneficial role of Stiloz for the treatment of neuropathy. However, human studies do not show any beneficial role of Stiloz in treating neuropathy.
Stiloz is safe if used at prescribed doses for the prescribed duration as advised by your doctor. However, there are some very common side effects that you can experience at therapeutic doses which include a headache, abnormal stool, and diarrhea.
Q. Can I take Stiloz with clopidogrel?
Stiloz, when taken with clopidogrel, is seen to improve long-term outcomes in patients undergoing percutaneous coronary angioplasty. However, there can be an increased risk of bleeding as both inhibit platelet aggregation and make blood thin. If you are taking Stiloz with clopidogrel, you should be monitored very closely by your doctor.
Q. How is Stiloz useful in arterial hypertension?
Stiloz is not useful for arterial hypertension. It is used in the management of intermittent claudication associated with peripheral artery disease.
Q. When should I stop taking Stiloz?
Do not stop Stiloz unless advised by your doctor. Continue to take Stiloz even if you feel better. Stop taking Stiloz only if you experience easy bruising, bleeding, fever or a sore throat and immediately inform your doctor.
Q. Can I take Stiloz with omeprazole?
Omeprazole can increase the level or effect of Stiloz by blocking its breakdown (inhibits metabolism). Avoid using them together. An alternative medicine should be preferred.
Q. Can I use Stiloz with atorvastatin?
Stiloz can be taken with atorvastatin. No harmful effects or drug interactions have been seen or reported when Stiloz is taken along with atorvastatin.
Q. Is Stiloz useful for aspirin allergy?
Stiloz can be used in place of aspirin in patients who have an allergy to a spirin.
Q. Is it advisable to take Stiloz with acenocoumarol?
Stiloz, when taken with acenocoumarol, can increase the risk of bleeding. So they should be used very cautiously and a regular monitoring by your doctor is advisable to decrease the risk of bleeding.
Q. Is Stiloz useful for the treatment of venous insufficiency?
There is no evidence at present which recommends the use of Stiloz in the routine therapy of venous insufficiency.
Q. Is Stiloz useful in treating diabetes?
Stiloz is not useful in lowering the blood sugar levels in patients with diabetes. However, as seen in some clinical studies, it may help in relieving the symptoms of intermittent claudication (pain, cramping, numbness, or weakness in the legs on walking) seen in some patients with diabetes.
Q. Why is Stiloz contraindicated in heart failure?
Stiloz can increase the patient's heart rate, affect the heart rhythm and there is clinical evidence that it can increase mortality in patients with heart failure. So, Stiloz is contraindicated in these patients.
Q. Is Stiloz an anticoagulant?
Stiloz is not an anticoagulant. It is a vasodilator with an anti-platelet aggregatory effect. It works by preventing platelets (blood cells) from sticking together and widens the blood vessels of the legs. This increases the blood flow in the peripheries.
No, Stiloz is not a statin. It is a vasodilator and inhibits platelet aggregation, and is useful in the treatment of peripheral vascular disease.
Q. Is Stiloz a blood thinner?
No, Stiloz is not a blood thinner. It is a vasodilator and inhibits platelet aggregation, and is useful in the treatment of peripheral vascular disease.
Q. Is Stiloz a beta blocker?
No, Stiloz is not a beta blocker. It is a vasodilator and inhibits platelet aggregation, and is useful in the treatment of peripheral vascular disease.
Q. Is Stiloz a better choice for the treatment of intermittent claudication compared to pentoxifylline?
Stiloz is seen to be much better than pentoxifylline for increasing walking distances in patients with intermittent claudication but is associated with increased rates of side effects like a headache, palpitations, and diarrhea.
Q. Is Stiloz a controlled substance?
Stiloz is not a controlled substance. It's a prescription medicine and is available on providing a valid prescription by a doctor.
Q. Is Stiloz a narcotic substance?
No, Stiloz is not a narcotic substance. It's a prescription medicine and is available on providing a valid prescription by a doctor.
Q. Is Stiloz an anticonception medicine?
No, Stiloz is not an anticonception medicine. It is a vasodilator and inhibits platelet aggregation. It is used to treat peripheral vascular disease.
Q. Is Stiloz an antibiotic?
No, Stiloz is not an antibiotic. It is a vasodilator and inhibits platelet aggregation. It is used to treat peripheral vascular disease.
Severely interacts with other drugs like
Taking Stiloz with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Medicines with composition Itraconazole: Itracip, Itraspan, Itzo, Canzit, Cositra, Itoz, Belitra, Sitra, Ozitral, Itrapro
Medicines with composition Lansoprazole: Legend, Lazole, Less, Zolitec, Lansad, Lanspic, Lansure, Wylan, Lanzyco, Dyzole
Medicines with composition Fluconazole: Fungis, EF Z, Rocflu, Welcon, Fluzole, Geoflu, Rascon, Con F, Fucan, Flucur
Medicines with composition Rabeprazole: Ulcevin, Altirab, Rabsure, Rabon, Rabequeen, Solrazole, R Od, Rabod, Rabgize, Rabepaa
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Medicines with composition Esomeprazole: Esodoc, Styx, Escid, Ubitwell, Antacer
Medicines with composition Omeprazole: Vinstom, Odizol, Omzee, Adzole, Omkar, Omecid, Omcar EC, Sancid, Ozad, Omzole
Medicines with composition Clotrimazole: Clowil, Odis, Kamestin
Medicines with composition Terbinafine: Terbicutis, Terminator, Hifen
Medicines with composition Simvastatin: Alvastin, Simaid
Medicines with composition Rosuvastatin: Rosidoc, Rosustin, Rosucad, Rosufix, Ingvas, Rosufine, Rosuzen, Statcare, Rosurax, Rosuvat
Medicines with composition Atorvastatin: Etovas, Alvastatin, Atalo, ETO, Statprime, Atarstin, Welstatin, LD Statin, Zovastin, Renovas
Medicines with composition Pitavastatin: Pevastin
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Medicines with composition Clarithromycin: Clarimac, CLR, Claripax, O Clar, Clarinic, C Cin, Klarim, Klarinton, Cloff
Medicines with composition Verapamil: Verpitos
Medicines with composition Nifedipine: Finidin
Medicines with composition Erythromycin: Arthrox, Ciresto, Eromax, Avithrocin, Denthrocin, E Cin, T Mycin
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