



Serestin Injection
Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 25 Nov 2025 | 03:05 PM (IST)
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General Information




Product introduction
Serestin Injection can also be used for treating psychosis, mania, severe behavior problems in adults and children. It is given as an injection under the supervision of a healthcare professional and should not be self-administered. Take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember it. Do not skip any doses and finish the full course of treatment even if you feel better. This medication mustn't be stopped suddenly without talking to your doctor as it may worsen your symptoms.
Some common side effects of this injection include dry mouth, abnormality of voluntary movements, urinary retention, constipation, and muscle rigidity. Initially, this medicine may cause a sudden drop in blood pressure when you change positions, rise slowly if you have been sitting or lying down. It may also cause dizziness and sleepiness, do not drive or do anything that requires mental focus until you know how this medicine affects you. This medicine can lead to weight gain, have a healthy balanced diet, and exercise regularly. You may also notice some injection site reactions such as pain, redness, or swelling. However, these are temporary and usually resolve on their own. Please consult your doctor in case these do not subside or bother you.
Before taking it, inform your doctor if you are suffering from thyroid or kidney problems, epilepsy, Parkinson’s disease, glaucoma, or any heart problems. You should not take this medicine if you are under the influence of alcohol or any sleep-inducing, cough, and/ or allergy medication. This medicine can also lead to weight gain, eat a healthy balanced diet, avoid snacking with high-calorie food, and exercise regularly.
Uses of Serestin Injection
Benefits of Serestin Injection
Schizophrenia is a mental disorder in which a person’s thinking ability, feelings, and behavior become abnormal. Serestin Injection helps restore the chemical imbalances in the brain that are responsible for such changes. It improves thoughts, behavior and enhances the quality of life. It is given as an injection by a doctor or nurse and should not be self-administered. Follow your doctor’s instructions carefully to get the maximum benefits.
Side effects of Serestin Injection
- Abnormality of voluntary movements
- Constipation
- Dryness in mouth
- Increased prolactin level in blood
- Orthostatic hypotension (sudden lowering of blood pressure on standing)
- Sleepiness
- Weight gain
How to use Serestin Injection
How Serestin Injection works
Quick tips
- Serestin Injection helps treat schizophrenia.
- It is less likely to cause weight gain as compared to other similar medicines.
- Use caution while driving or doing anything that requires concentration as Serestin Injection may cause dizziness and sleepiness.
- Avoid drinking alcohol while taking this medicine as it can cause increased dizziness.
- Inform your doctor if you experience any abnormal movements or have difficulty controlling movements.
- It may affect how your body regulates your temperature. Avoid getting dehydrated and drink plenty of fluids.
- Your doctor may check your heart function and level of electrolytes such as sodium and magnesium before you start treatment with this medicine and regularly thereafter.
- Do not stop taking Serestin Injection without talking to your doctor first as it may cause worsening of symptoms.
Safety advice

Alcohol

Pregnancy

Breast feeding
If Serestin Injection is used, monitor the baby for excessive sleepiness.

Driving

Kidney
However, patients with severe kidney disease may need to be started at a lower dose as it may cause excessive sleepiness in these patients.

Liver
Interaction with drugs
Clozapine (Oral Route)
Fact Box
Chemical Class
Habit Forming
Therapeutic Class
Action Class
References
- Stahl SM, editor. Haloperidol. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 291-96.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 646-48.
- Haloperidol. Titusville, NJ: Janssen Pharmaceuticals; 2005 [revised Jan. 2016]. [Accessed 25 Mar. 2019] (online) Available from:
- Chaves RG, Lamounier JA. Breastfeeding and maternal medications. Jornal de Pediatria. 2004;80(5):4-6. [Accessed 20 Mar. 2019] (online) Available from:
- Haloperidol [EMC SmPC]. London, UK: ADVANZ Pharma; 1989 [revised 1 Sep. 2017]. [Accessed 25 Mar. 2019] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 25 Mar. 2019] (online) Available from:




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